Target Striatal Cells Regulate Development of Midbrain Dopaminergic Neurones

Perrone-Capano, Carla; Amadoro, Giuseppina; Tino, Angela; Pernas-Alonso, Roberto; Esposito, Bruno; Porzio, Umberto di

doi:10.1007/978-1-4615-5899-6_8

Cited by 3 publications

(22 citation statements)

References 41 publications

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“…The mesolimbic pathway is involved in reward behavior and is implicated in neurobiological theories of addiction, particularly because of its connection to the NAc [61, 124]. Disruption of DA function in the NAc by drugs of abuse, such as cocaine, is exaggerated with HIV-1 proteins [93, 125] and may underlie the increased prevalence of neurological complications in HIV-1-infected drug users relative to HIV-infected patients without a history of drug use [110].…”

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

“…The second class of DA afferents originates in the SN, are highly collateralized, and project to the superficial cortical layers (I–III) in the anterior cingulate cortex [126]. The mesocortical pathway is essential to the functional integrity of the dorsolateral prefrontal cortex and is involved in emotion, motivation, and memory [61, 124]. Disruptions of this system are associated with schizophrenia (negative symptoms), addictive behavioral disorders, as well as attention-deficit hyperactivity disorder (ADHD).…”

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

“…In rats, TH + cells can be detected in the midbrain as early as E11-12; TH is also detected in axons and axonal growth cones at this stage [134]. At E13-14, the first terminal fields of TH + labeled cells are detected in the striatum [124, 134]. The localization of TH + neurons in the human fetus displays similar essential features to those of the rat fetus [135].…”

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

“…At E12.5 DA neurons express the c- ret proto-oncogene and GFRα1 (mRNA) and endogenous DA levels are detectable in the developing rat midbrain (A9, A10). The concentration of DA neurons increases sharply at E16, attaining a plateau before birth [124]. Besides DA gene expression, D 2 -like autoreceptors are detected in the midbrain of rats at E13–E14, two days after TH + immunoreactivity, with their number increasing thereafter, and their expression prior to the functional onset of DA neurotransmission.…”

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

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HIV-1 Proteins, Tat and gp120, Target the Developing Dopamine System

Fitting¹,

Booze

Mactutus³

2015

CHR

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In 2014, 3.2 million children (< 15 years of age) were estimated to be living with HIV and AIDS worldwide, with the 240,000 newly infected children in the past year, i.e., another child infected approximately every two minutes [1]. The primary mode of HIV infection is through mother-to-child transmission (MTCT), occurring either in utero, intrapartum, or during breastfeeding. The effects of HIV-1 on the central nervous system (CNS) are putatively accepted to be mediated, in part, via viral proteins, such as Tat and gp120. The current review focuses on the targets of HIV-1 proteins during the development of the dopamine (DA) system, which appears to be specifically susceptible in HIV-1-infected children. Collectively, the data suggest that the DA system is a clinically relevant target in chronic HIV-1 infection, is one of the major targets in pediatric HIV-1 CNS infection, and may be specifically susceptible during development. The present review discusses the development of the DA system, follows the possible targets of the HIV-1 proteins during the development of the DA system, and suggests potential therapeutic approaches. By coupling our growing understanding of the development of the CNS with the pronounced age-related differences in disease progression, new light may be shed on the neurological and neurocognitive deficits that follow HIV-1 infection.

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Section: Neural Development Of the Da Systemmentioning

confidence: 99%

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

Section: Neural Development Of the Da Systemmentioning

confidence: 99%

See 2 more Smart Citations

HIV-1 Proteins, Tat and gp120, Target the Developing Dopamine System

Fitting¹,

Booze

Mactutus³

2015

CHR

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“…Interactions of patch or matrix neurons with their specific target cells might influence, via retrograde signalling, the molecular composition of postsynaptic densities and, thus, the expression of AKAP79 [Perrone-Capano et al, 1996].…”

Section: Features Of the Distribution Pattern Of Akap79-ir Structuresmentioning

confidence: 99%

Development-Related Expression of AKAP79 in the Striatal Compartments of the Human Brain

Ulfig

Neudörfer

Bohl

2001

Cells Tissues Organs

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The expression of AKAP79 which tethers regulatory proteins within postsynaptic densities has been studied in the two striatal compartments, i.e. patches and matrix, at different stages of the developing human brain by means of immunohistochemistry. The two striatal compartments exhibit various intensities of diffuse immunolabelling and a different number of immunoreactive nerve cells. From the 14th to 20th gestational week a nearly homogeneous distribution of immunoreactive structures in the two compartments of the striatum is seen. Thereafter, a decrease in immunoreactive structures within the matrix is observed (22nd–25th week, intermediate stage). From the 27th week onwards the patch compartment contains distinctly more immunoreactive puncta and nerve cells. Thus, the patches stand out clearly in the immunopreparations. This distribution pattern does not change during proceeding development. AKAP79-immunoreactive nerve cells closely resemble those constituting the class of medium-sized inhibitory projection neurons that receive the dopaminergic input of the striatum. Literature data suggest that AKAP79 may be functionally attributed to dopaminergic inputs. Accordingly, the patterns of AKAP79 expression can at least in part be correlated with the sequential occurrence of dopaminergic innervation. The mature matrix containing a dopaminergic innervation being as dense as in the patches displays distinctly less AKAP79-immunoreactive neurons and puncta than the patches. This discrepancy might indicate that a subpopulation of matrix neurons may, despite dopaminergic input, not express AKAP79.

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Chronic activation of ERK and neurodegenerative diseases

2003

Self Cite

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The extracellular-signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK-expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization.

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Target Striatal Cells Regulate Development of Midbrain Dopaminergic Neurones

Cited by 3 publications

References 41 publications

HIV-1 Proteins, Tat and gp120, Target the Developing Dopamine System

HIV-1 Proteins, Tat and gp120, Target the Developing Dopamine System

Development-Related Expression of AKAP79 in the Striatal Compartments of the Human Brain

Chronic activation of ERK and neurodegenerative diseases

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