Targeted Agents in Cervical Cancer: Beyond Bevacizumab

Marquina, Gloria; Manzano, Aránzazu; Casado, Antonio

doi:10.1007/s11912-018-0680-3

Cited by 88 publications

(67 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two-thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates ( Marquina et al, 2018 ). Thus, an effective and safe therapy for cervical cancer is urgently needed.…”

Section: Genitourinary Organ Cancersmentioning

confidence: 99%

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

et al. 2018

View full text Add to dashboard Cite

It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops (Humulus lupulus L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed.

show abstract

Section: Genitourinary Organ Cancersmentioning

confidence: 99%

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…1 More than 274 000 individuals die each year. 2 In China, approximately 98 900 new cases were diagnosed in 2015, which accounted for 18.7% of the global incidence. 3 Additionally, 30% of patients were <44 years old.…”

Section: Introductionmentioning

confidence: 99%

Retracted: INPP1 up‐regulation by miR‐27a contributes to the growth, migration and invasion of human cervical cancer

Zhang

Tang

2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Inositol polyphosphate‐1‐phosphatase (INPP1) is an enzyme that is responsible for glycolysis and lipid metabolism. Here, we discovered that INPP1 expression was up‐regulated in CC tissues compared to that in adjacent normal tissues by RT‐qPCR. Inositol polyphosphate‐1‐phosphatase overexpression promoted and INPP1 knockdown suppressed cell viability, cellular migration/invasion and EMT in CC cells. To explore the mechanism of dysregulation, INPP1 was predicted to be a target of miR‐27a, and a pmiRGLO dual‐luciferase reporter assay showed that miR‐27a bound to the 3′ UTR of INPP1. RT‐qPCR revealed that miR‐27a was also up‐regulated and had a positive correlation with INPP1 expression in CC tissues. Furthermore, shR‐INPP1 could favour the malignant phenotype reversion induced by miR‐27a, suggesting that miR‐27a up‐regulates INPP1 to promote tumorigenic activities. Altogether, our findings show that the up‐regulation of INPP1 by miR‐27a contributes to tumorigenic activities and may provide a potential biomarker for CC.

show abstract

“…Another most reliable method of treatment of metastatic cervical cancer for years is platinum-based chemotherapy but has not shown any major improvements in survival rate [4,5]. The other causes of carcinoma cervix are etiological points various oncogenic microorganisms, dietary factors, low socio income group, immune system, and epigenetic factors [6,7].…”

Section: Introductionmentioning

confidence: 99%

A Prospective Study of Serum Folate Concentration and Hemoglobin in Cervix Carcinoma Patients

Sharma²,

Mishra

2021

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The study aimed to have a prospective study of serum folate concentration and hemoglobin (Hb%) in cervical carcinoma patients. Methods: The study was conducted on women suffering from carcinoma cervix. The research was conducted in the Gynecological Outpatient Department (OPD) of the Oncology Unit in Mahavir Cancer Sansthan Patna, Bihar. The study period was from May 2016 to April 2017. The sample was collected after face to face interview by Figo staging and the sample was taken regularly. As a result strong association of Hb% and carcinoma cervix was found with the mean value of lower than 11.12, which is lower than the normal range of Hb%. As per the further estimation of folic acid, the level of cervical cancer is low. Results: The data were estimated with help of tools such as SPSS 16.0 and PRISMA 5.0. The Hb% the mean value of patients was estimated to be lower than 11.12, which is not under the normal range of Hb%, that is, nearly 12.5 mg/dl. The low mean value shows less Hb% content which leads to anemia in normal beings as well as in patients with cervical cancer. A strong association of Hb% which affected to patients in carcinoma cervix can be seen in the graph that the mean value of patients low 11.12±0.20 which not comes under normal range of Hb%, that is, 12.5 mg/dl. The R square value is 0.9556. Conclusion: As per our study, we have estimated that the folic acid level in cervical cancer is low. The -normal range of folic acid level in plasma serum is 2.2–20 ug/ml. The mean of 20 control cases, new cervical cancer patients, on treating patients, and follow-up patients is 11.08, 2.206, 3.554, and 2.783, respectively. The control 11.08 shows the better level in plasma serum level comes under a normal range of folic acid level.

show abstract

Targeted Agents in Cervical Cancer: Beyond Bevacizumab

Cited by 88 publications

References 58 publications

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

Retracted: INPP1 up‐regulation by miR‐27a contributes to the growth, migration and invasion of human cervical cancer

A Prospective Study of Serum Folate Concentration and Hemoglobin in Cervix Carcinoma Patients

Contact Info

Product

Resources

About