Targeted and non-targeted liquid chromatography-mass spectrometric workflows for identification of transformation products of emerging pollutants in the aquatic environment

Bletsou, Anna A.; Jeon, Junho; Hollender, Juliane; Archontaki, Eleni; Thomaidis, Nikolaos S.

doi:10.1016/j.trac.2014.11.009

Cited by 300 publications

(194 citation statements)

References 90 publications

Supporting

Mentioning

192

Contrasting

Unclassified

Order By: Relevance

“…Most studies are initially based on laboratory experiments at elevated concentrations to facilitate the identication of TPs, [22][23][24] which are then searched for in environmental samples. 16,25,26 Strategies have also been developed to assist and simplify the detection of TPs directly in natural waters and wastewater, based on the use of characteristic fragmentation 27,28 or mass defect ltering. 29 Such applications mostly contribute with information on the occurrence of TPs 18,25 likely formed under the conditions during conventional wastewater treatment processes and emitted directly from the WWTPs.…”

Section: Introductionmentioning

confidence: 99%

A strategic screening approach to identify transformation products of organic micropollutants formed in natural waters

Kaserzon

Plassmann

et al. 2017

Environ. Sci.: Processes Impacts

View full text Add to dashboard Cite

Many transformation products (TPs) from organic micropollutants are not included in routine environmental monitoring programs due to limited knowledge of their occurrence and fate. An efficient method to identify and prioritize critical compounds in terms of environmental relevance is needed. In this study, we applied a strategic screening approach based on a case-control concept to identify TPs formed along wastewater-impacted rivers. Time-integrated samples were collected over one week at both ends of a river stretch downstream of a wastewater treatment plant (WWTP) outfall and were analyzed by ultrahigh performance liquid chromatography interfaced with quadrupole time-of-flight mass spectrometry (UHPLC-QToF-MS/MS). The screening procedure of the high-resolution MS (HRMS) datasets consisted of three major steps: (i) screening for parent compounds (PCs) attenuated along the stretch; (ii) prediction of potential TPs from these PCs; and (iii) screening for TPs from this list with an increasing trend along the stretch. In total, 32 PCs decreased along the investigated river stretches. From these PCs, eight TPs had increasing concentrations along the studied stretches and could be tentatively identified. The identification of one TP (benzamide) was confirmed by its corresponding reference standard, while no standards were available for the remaining TPs. Environmental impactOrganic micropollutants are continuously discharged from wastewater treatment plants into receiving aquatic systems where they undergo further transformation. The number of unknown transformation products is large; hence prioritizations for analysis and risk assessment are needed. We established a strategic screening approach to identify micropollutant transformation products formed in wastewater-impacted rivers. The essential case-control concept effectively allocates attenuating parent micropollutants and transformation products generated in situ. Our screening concept can be applied in process-oriented studies at both laboratory and eld scale to identify unknown transformation products prioritized for further investigation. EU chemical legislation calls for hazard assessments of formed transformation products, when motivated. The concept presented in this study can help to identify such transformation products, and thereby contribute to a more comprehensive risk assessment for parent chemicals.

show abstract

Section: Introductionmentioning

confidence: 99%

A strategic screening approach to identify transformation products of organic micropollutants formed in natural waters

Kaserzon

Plassmann

et al. 2017

Environ. Sci.: Processes Impacts

View full text Add to dashboard Cite

show abstract

“…in WWTPs) and on the surrounding water of SWTPs in order to protect water quality and avoid consumption or usage of contaminated water that can cause health problems (Directive 2013/39/EU). In addition, emerging contaminants can be a potential risk to the environment and for human health safety, but they are not currently covered by water-quality regulations (Bletsou et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive monitoring of organic micro-pollutants in surface and groundwater in the surrounding of a solid-waste treatment plant of Castellón, Spain

Pitarch

Cervera

Portolés

et al. 2016

Science of The Total Environment

View full text Add to dashboard Cite

The solid-waste treatment plant of RECIPLASA is located in the municipality of Onda (Castellón province), which is an important agricultural area of Spain, with predominance of citrus crops. In this plant, all urban solid wastes from the town of Castellón (around 200.000 inhabitants) and other smaller towns as Almassora, Benicàssim, Betxí, Borriana, L'Alcora, Onda and Vila-Real are treated. In order to evaluate the potential impact of this plant on the surrounding water, both surface and groundwater, a comprehensive monitoring of organic pollutants has been carried out along 2011, 2012 and 2013. To this aim, an advanced analytical strategy was applied for wide-scope screening, consisting on the complementary use of liquid chromatography (LC) and gas chromatography (GC) coupled to mass spectrometry (MS) with quadrupole (Q)-time of flight analyser (TOF). A generic solid-phase extraction with Oasis HLB cartridges was applied prior to the chromatographic analysis. The screening included more than 1,500 organic pollutants as target compounds, such as pesticides, pharmaceuticals, veterinary drugs, drugs of abuse, UV-filters, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), among others. Pesticides, mainly herbicides, were the compounds more frequently detected. Other compounds as antioxidants, cosmetics, drugs of abuse, PAHs, pharmaceuticals and UV filters, were also identified in the screening though at much lower frequency.Once the screening was made, quantitative analysis focused on the compounds more frequently detected was subsequently applied using LC coupled to tandem MS with triple quadrupole analyzer. In this way, up to 24 pesticides and transformation products (TPs), 7 pharmaceuticals, one drug of abuse and its metabolite could be quantified at sub-ppb concentrations. Along the three years of study, ten compounds were found at 3 concentrations higher than 0.1 g/L. Most of them were pesticides and TPs, a fact that illustrates that the main source of pollution seems to be the agricultural activities in this area.

show abstract

“…Their inevitable entry into the environment affects all compartments. These compounds and their degradation products and/or metabolites must be monitored since their eco-toxicity can be comparable or more dangerous than those of the original compounds [3,4].…”

Section: Introductionmentioning

confidence: 99%

Applications of Fabric Phase Sorptive Extraction to the Determination of Micropollutants in Liquid Samples

et al. 2018

View full text Add to dashboard Cite

Abstract:The occurrence of organic micropollutants (OMPs) in the environment is a global concern due to their potential ecological risks. Several studies have shown that some OMPs are widely detected in environmental matrices such as surface water and sewage. Wastewater treatment plants (WWTPs) have received international attention over past decades because they are considered the greatest source of aquatic environmental contamination by anthropogenic micropollutants. Intensive sampling and analysis have been globally made to improve understanding of the occurrence, behavior and fate of OMPs in WWTPs using different types of analytical approach. Recently, special awareness has been devoted to developing new effective strategies to extract the micropollutants of wastewater. In particular, microextraction protocols have gained popularity because of their simplicity, low cost and in-field application for environmental analysis. Among these, fabric phase sorptive extraction (FPSE) is reported as an excellent approach due to its properties, not only reducing the required time but also employing minor solvent volume. In this overview, we summarize the results obtained by the Research Group of Environmental Chemical Analysis of the University of Las Palmas de Gran Canaria (Spain) using this technique. Its aim is to show the potential of FPSE for the extraction of some micropollutants, such as personal care products (benzotriazole ultraviolet stabilizers (BUVSs)) and pharmaceuticals (steroid hormones and cytostatic compounds) in different liquid samples, prior to their determination by liquid chromatography.

show abstract

Targeted and non-targeted liquid chromatography-mass spectrometric workflows for identification of transformation products of emerging pollutants in the aquatic environment

Cited by 300 publications

References 90 publications

A strategic screening approach to identify transformation products of organic micropollutants formed in natural waters

A strategic screening approach to identify transformation products of organic micropollutants formed in natural waters

Comprehensive monitoring of organic micro-pollutants in surface and groundwater in the surrounding of a solid-waste treatment plant of Castellón, Spain

Applications of Fabric Phase Sorptive Extraction to the Determination of Micropollutants in Liquid Samples

Contact Info

Product

Resources

About