Targeted Biopsies Identify Larger Proportions of Patients With Colonic Neoplasia Undergoing High-Definition Colonoscopy, Dye Chromoendoscopy, or Electronic Virtual Chromoendoscopy

Gasia, Miriam Fort; Ghosh, Subrata; Panaccione, Remo; Ferraz, José G.; Kaplan, Gilaad G.; Leung, Yvette; Novak, Kerri L.; Seow, Cynthia H.; Iacucci, Marietta

doi:10.1016/j.cgh.2015.12.047

Cited by 68 publications

(55 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, the study design doesn't allow answering whether extra random biopsies might still be useful in this setting. However, based on previous evidence showing the marginal yield of random biopsies,26 28 especially when using CE,5 34 we believe that this is not a main clinical issue, as reflected by current guidelines 8–11. Finally, because of a relatively small sample size, comparisons between endoscopists and techniques are weak and should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 88%

Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD

Carballal

Maisterra

López-Serrano

et al. 2016

Gut

119

114

View full text Add to dashboard Cite

Objective Outside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess the effectiveness of CE for neoplasia detection and characterisation, in real-life. Design From June 2012 to 2014, patients with IBD were prospectively included in a multicentre cohort study. Each colonic segment was evaluated with white light followed by 0.4% indigo carmine CE. Specific lesions' features were recorded. Optical diagnosis was assessed. Dysplasia detection rate between expert and non-expert endoscopists and learning curve were ascertained.

show abstract

Section: Discussionmentioning

confidence: 88%

Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD

Carballal

Maisterra

López-Serrano

et al. 2016

Gut

119

114

View full text Add to dashboard Cite

show abstract

“…Of these, 10 were included in the final qualitative and quantitative analysis. 7,18,[23][24][25][26][27][28][29][30] See Table 1 for a summary of the trials included. In total, 731 patients underwent a colonoscopy evaluation with dye-based chromoendoscopy compared with 831 patients in the non-chromoendoscopy arm.…”

Section: Resultsmentioning

confidence: 99%

“…25,26 Chromoendoscopy was compared with SDWLE in 3 RCTs and in 2 non-RCTs. 7,18,23,24,28 Chromoendoscopy was compared with HDWLE in 3 RCTs and in 3 non-RCTs. [25][26][27][28][29][30] Chromoendoscopy compared with standarddefinition colonoscopy and high-definition colonoscopy in the detection of dysplasia in RCTs…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of dye-based chromoendoscopy compared with standard- and high-definition white-light endoscopy in patients with inflammatory bowel disease at increased risk of colon cancer

Feuerstein

Rakowsky

Sattler

et al. 2019

Gastrointestinal Endoscopy

View full text Add to dashboard Cite

Background: Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rate the quality of evidence using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) system. Methods: A systematic review of the literature in PubMed, EMBASE, and Web of Science was performed in April 2018. The primary outcome was the number of patients in whom dysplasia was identified using a per patient analysis in randomized controlled trials (RCT) and analyzed separately for non-RCTs. Analysis was performed using RevMan 5.3 reporting random-effects risk ratios. Results: Of the 27,904 studies identified, 10 studies were included 6 of which were RCTs (3 SDWLE and 3 HDWLE). Seventeen percent (84/494) of patients were noted to have dysplasia using chromoendoscopy compared with 11% (55/496) with white-light endoscopy (relative risk [RR] 1.50; 95% confidence interval [CI], 1.08-2.10). When analyzed separately, chromoendoscopy (n Z 249) was more effective at identifying dysplasia than SDWLE (n Z 248) (RR, 2.12; 95% CI, 1.15-3.91), but chromoendoscopy (n Z 245) was not more effective compared with HDWLE (n Z 248) (RR, 1.36; 95% CI, 0.84-2.18). The quality of evidence was moderate. In non-RCTs, dysplasia was identified in 16% (114/698) of patients with chromoendoscopy compared with 6% (62/1069) with white-light endoscopy (RR, 3.41; 95% CI, 2.13-5.47). Chromoendoscopy (n Z 58) was more effective than SDWLE (n Z 141) for identification of dysplasia (RR, 3.52; 95% CI, 1.38-8.99), and chromoendoscopy (n Z 113) was also more effective than HDWLE (n Z 257) (RR, 3.15; 95% CI, 1.62-6.13). The quality of the evidence was very low. Conclusion: Based on this meta-analysis, non-RCTs demonstrate a benefit of chromoendoscopy over SDWLE and HDWLE, whereas RCTs only show a small benefit of chromoendoscopy over SDWLE, but not over HDWLE.

show abstract

“…Der Unterschied bezüglich der Dysplasiefindung war allerdings bei dem Vergleich zwischen Chromoendoskopie und nicht hochauflösender Weißlichtendoskopie (WLE) signifikant. Zu einem ähnlichen Ergebnis kommt eine unizentrische Studie aus Kanada [208], die 454 IBD-Patienten in einem Surveillance-Programm untersuchte. Danach war das Ergebnis zur Erkennung von Dysplasien bei gezielten Biopsien besser als bei Zufallsbiopsien in der HDWLE und in der Chromoendoskopie.…”

Section: Empfehlung 232unclassified

Aktualisierte S3-Leitlinie Colitis ulcerosa der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

2018

Z Gastroenterol

View full text Add to dashboard Cite

This guideline provides evidence-based key recommendations for diagnosis and treatment of ulcerative colitis and upgrades the 2011 version. The guideline was developed by an interdisciplinary team of gastroenterologists, surgeons, pathologists, nutrition experts, and patient support groups under the auspice of the German Society for Gastroenterology and Metabolic Diseases. The guideline used structural S3 consensus-based methodology and includes statements on clinical practice, prevention, infectiological problems, surgery and nutrition.

show abstract

Targeted Biopsies Identify Larger Proportions of Patients With Colonic Neoplasia Undergoing High-Definition Colonoscopy, Dye Chromoendoscopy, or Electronic Virtual Chromoendoscopy

Cited by 68 publications

References 40 publications

Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD

Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD

Meta-analysis of dye-based chromoendoscopy compared with standard- and high-definition white-light endoscopy in patients with inflammatory bowel disease at increased risk of colon cancer

Aktualisierte S3-Leitlinie Colitis ulcerosa der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

Contact Info

Product

Resources

About