Targeted cancer imaging and photothermal therapy via monosaccharide-imprinted gold nanorods

Yin, Daqiang; Li, Xingling; Ma, Yanyan; Liu, Zhen

doi:10.1039/c7cc02247f

Cited by 151 publications

(93 citation statements)

References 47 publications

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“…Interestingly, it has been reported that constructs based on gold nanorods exhibit nearly twofold higher signal‐to‐noise ratio than constructs based on gold nanospheres . Furthermore, because gold nanorods absorb near‐infrared light, they have been widely used in the literature for photothermal therapy, making them candidates for use in theranostic platforms …”

Section: Hybridization‐based Probesmentioning

confidence: 99%

“…[194] Furthermore, because gold nanorods absorb near-infrared light, they have been widely used in the literature for photothermal therapy, making them candidates for use in theranostic platforms. [195][196][197] In a strategy analogous to that used with spherical gold NP-MBs, Wang et al used gold nanorod MBs for detection of Dll4 mRNA in HUVEC cells. [194] Importantly, they were able to track Dll4 mRNA and study its dynamics in individual cells.…”

Section: Gold Nanoparticle Basedmentioning

confidence: 99%

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Nucleic‐Acid Structures as Intracellular Probes for Live Cells

2019

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The chemical composition of cells at the molecular level determines their growth, differentiation, structure, and function. Probing this composition is powerful because it provides invaluable insight into chemical processes inside cells and in certain cases allows disease diagnosis based on molecular profiles. However, many techniques analyze fixed cells or lysates of bulk populations, in which information about dynamics and cellular heterogeneity is lost. Recently, nucleic‐acid‐based probes have emerged as a promising platform for the detection of a wide variety of intracellular analytes in live cells with single‐cell resolution. Recent advances in this field are described and common strategies for probe design, types of targets that can be identified, current limitations, and future directions are discussed.

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Section: Hybridization‐based Probesmentioning

confidence: 99%

Section: Gold Nanoparticle Basedmentioning

confidence: 99%

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

2019

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“…MIPs have found important applications in many areas,s uch as separation, [16] sensing, [17] drug delivery, [18] disease diagnosis, [19] and photothermal therapy of cancer. [20] Clearly,the use of MIPs as cancer therapeutic agents is still at av ery early stage and further evidence of inhibiting cancer signaling pathways by MIPs are essential to promote the development of MIPs for cancer therapy.…”

Section: Inhibition Of Her2-positiveb Reast Cancer Growth By Blockingmentioning

confidence: 99%

“…According to the boronate-affinity-controllable oriented surface imprinting approach, the thickness of the imprinting layer was directly proportional to the imprinting time. [20] According to the estimated length of the glycans (Supporting Information, Figure S1), we optimized the imprinting by setting the polymerization time at 40, 50, 60, and 70 min and evaluated the imprinting effect in terms of imprinting factor (IF). TheIF value was calculated according to the ratio of the fluorescence…”

Section: Inhibition Of Her2-positiveb Reast Cancer Growth By Blockingmentioning

confidence: 99%

Inhibition of HER2‐Positive Breast Cancer Growth by Blocking the HER2 Signaling Pathway with HER2‐Glycan‐Imprinted Nanoparticles

Dong

et al. 2019

Angew Chem Int Ed

Self Cite

162

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Blocking the HER2 signaling pathway has been an effective strategy in the treatment of HER2-positive breast cancer.I tm ainly relies on the use of monoclonal antibodies and tyrosine-kinase inhibitors.H erein, we present an ew strategy,the nano molecularly imprinted polymer (nanoMIP). The nanoMIPs,imprinted using HER2 N-glycans,could bind almost all HER2 glycans and suppress the dimerization of HER2 with other HER family members,b locking the downstream signaling pathways,t herebyi nhibiting HER2 + breast cancer growth. In vitro experiments demonstrated that the nanoMIPs specifically targeted HER2 + cells and inhibited cell proliferation by 30 %. In vivo experiments indicated that the mean tumor volume of the nanoMIP-treated group was only about half of that of the non-treated groups.T his study provides not only an ew possibility to treat of HER2 + breast cancer but also new evidence to boost further development of nanoMIPs for cancer therapy.

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“…Nanoparticles of gold (AuNPs) are known to be a promising material in terms of their application in biomedicine as biosensors [1][2][3], biomarkers [4,5], and for bioimaging [6,7], drug delivery [8,9] etc. Additionally, AuNPs deposited onto Si substrate exhibit surface plasmon resonance [10] which might help to improve overall catalytic property of Si-based materials and thereby enhance performances of devices based on such materials, e.g.…”

Section: Introductionmentioning

confidence: 99%

Optimal Conditions for the Deposition of Gold Nanofilms on a Silicon by Galvanic Replacement Method

Nichkalo

Shepida

Chekaylo

2019

PCSS

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The formation conditions of gold nanofilms on silicon (Si) substrate by galvanic replacement in a dimethyl sulfoxide (DMSO) solvent and their subsequent use for the fabrication of Si nanostructures by metal-assisted chemical etching (MACE) method were under study. It was found that the average size and number of Au nanoparticles increase with an increase in the reducible metal ion concentration from 2 to 8 mM HAuCl 4 in DMSO, whereas the distribution of Au nanoparticles in height remains low for all concentrations of the reducible metal. In the temperature range 40 -70°C, a different morphology of the deposited Au nanofilms observed. In particular, at 40 °C, the film is porous mainly homogeneous, whereas at a temperature of 50°C the film is rougher. The subsequent rise in temperature from 60°C to 70°C results in the formation of Au nanofilm with a discontinuous morphology. It was established that regardless of the morphology of deposited Au nanofilms, the Si nanostructures maintain a vertical orientation to the plane of the Si substrate during MACE-etching. The produced Si nanostructures were 1.5 -2.5 μm in height and their average diameter ranged from 100 to 300 nm.

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Targeted cancer imaging and photothermal therapy via monosaccharide-imprinted gold nanorods

Cited by 151 publications

References 47 publications

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

Inhibition of HER2‐Positive Breast Cancer Growth by Blocking the HER2 Signaling Pathway with HER2‐Glycan‐Imprinted Nanoparticles

Optimal Conditions for the Deposition of Gold Nanofilms on a Silicon by Galvanic Replacement Method

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