Targeted combination therapy for glioblastoma by co-delivery of doxorubicin, YAP-siRNA and gold nanorods

Li, Lihuang; Guo, Qisen; Liu, Yanxiu; Lu, Mindan; Yang, Jun; Ge, Yunshan; Qiang, Zhang; Benqiang, Sun; Wang, Xiumin; Li, Liangcheng; Ren, Lei

doi:10.1016/j.jmst.2020.03.009

Cited by 11 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…D/R@Ang2-Lip+Au, a doxorubicin-and YAP-siRNA-loaded cationic liposome, was able to effectively inhibit glioblastoma. 369 In addition, another YAP-siRNAlipid nanoparticle repressed hepatocellular carcinoma in a mouse model. 370 In addition to cancer treatment, YAP-siRNA was effective in treating posterior segment neovascularization-related ocular diseases.…”

Section: Dysregulation Of the Hippo Pathway And Human Diseasesmentioning

confidence: 99%

The Hippo signalling pathway and its implications in human health and diseases

Lan

et al. 2022

Sig Transduct Target Ther

231

View full text Add to dashboard Cite

As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in the regulation of numerous biological processes. Thus, substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway, as well as its physiological functions, such as cell proliferation and differentiation, organ growth, embryogenesis, and tissue regeneration/wound healing. However, dysregulation of the Hippo pathway can cause a variety of diseases, including cancer, eye diseases, cardiac diseases, pulmonary diseases, renal diseases, hepatic diseases, and immune dysfunction. Therefore, therapeutic strategies that target dysregulated Hippo components might be promising approaches for the treatment of a wide spectrum of diseases. Here, we review the key components and upstream signals of the Hippo pathway, as well as the critical physiological functions controlled by the Hippo pathway. Additionally, diseases associated with alterations in the Hippo pathway and potential therapies targeting Hippo components will be discussed.

show abstract

Section: Dysregulation Of the Hippo Pathway And Human Diseasesmentioning

confidence: 99%

The Hippo signalling pathway and its implications in human health and diseases

Lan

et al. 2022

Sig Transduct Target Ther

231

View full text Add to dashboard Cite

show abstract

“…In addition, the system inhibited tumorigenesis, induced CD133+ glioma cell apoptosis, and prolonged survival in intracranial glioma tumor-bearing nude mice. Recently, synergistic tumor-inhibitory effects were also noted with an Angiopep-2 decorated cationic liposome that simultaneously delivered doxorubicin, yes-associated protein (YAP) siRNA, and gold nanorods [129].…”

Section: Drug and Nucleic Acid Co-deliverymentioning

confidence: 99%

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Habib

Singh

2022

Polymers

View full text Add to dashboard Cite

Nanotechnology has opened up a world of possibilities for the treatment of brain disorders. Nanosystems can be designed to encapsulate, carry, and deliver a variety of therapeutic agents, including drugs and nucleic acids. Nanoparticles may also be formulated to contain photosensitizers or, on their own, serve as photothermal conversion agents for phototherapy. Furthermore, nano-delivery agents can enhance the efficacy of contrast agents for improved brain imaging and diagnostics. However, effective nano-delivery to the brain is seriously hampered by the formidable blood–brain barrier (BBB). Advances in understanding natural transport routes across the BBB have led to receptor-mediated transcytosis being exploited as a possible means of nanoparticle uptake. In this regard, the oligopeptide Angiopep-2, which has high BBB transcytosis capacity, has been utilized as a targeting ligand. Various organic and inorganic nanostructures have been functionalized with Angiopep-2 to direct therapeutic and diagnostic agents to the brain. Not only have these shown great promise in the treatment and diagnosis of brain cancer but they have also been investigated for the treatment of brain injury, stroke, epilepsy, Parkinson’s disease, and Alzheimer’s disease. This review focuses on studies conducted from 2010 to 2021 with Angiopep-2-modified nanoparticles aimed at the treatment and diagnosis of brain disorders.

show abstract

“…For example, DNA and RNA strands are stabilized on the surface of GNRs in different nanosystem designs for brain drug delivery. GNRs have been applied in a nanosystem designed for glioblastoma therapy by combining thermal therapy and inhibiting a protein expression, which is expected to make the glioblastoma more sensitive to chemotherapy [ 131 ]. The system consists of a liposome with a cationic-charged surface, modified by angiopep-2 peptide and loaded internally with DOX (a chemotherapeutic agent) and externally with GNRs (photothermal therapeutic agents) and yes-associated protein siRNA (YAP-siRNA), responsible for inhibiting the expression of YAP protein ( Figure 2 A).…”

Section: Gnrs For Therapeutic Applicationsmentioning

confidence: 99%

“…The system consists of a liposome with a cationic-charged surface, modified by angiopep-2 peptide and loaded internally with DOX (a chemotherapeutic agent) and externally with GNRs (photothermal therapeutic agents) and yes-associated protein siRNA (YAP-siRNA), responsible for inhibiting the expression of YAP protein ( Figure 2 A). The system showed good tumor growth inhibition effects and could pass the blood–brain barrier [ 131 ].…”

Section: Gnrs For Therapeutic Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements

et al. 2022

View full text Add to dashboard Cite

Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both NIR-responsive cargo delivery and photothermal/photodynamic therapies. In this review, a comprehensive insight into the properties, synthesis methods and toxicity of gold nanorods are overviewed first. For the main body of the review, the therapeutic applications of GNRs are provided in four main sections: (i) drug delivery, (ii) gene delivery, (iii) photothermal/photodynamic therapy, and (iv) theranostics applications. Finally, the challenges and future perspectives of their therapeutic application are discussed.

show abstract

Targeted combination therapy for glioblastoma by co-delivery of doxorubicin, YAP-siRNA and gold nanorods

Cited by 11 publications

References 33 publications

The Hippo signalling pathway and its implications in human health and diseases

The Hippo signalling pathway and its implications in human health and diseases

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements

Contact Info

Product

Resources

About