Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes

Yu, Baodan; Tan, Li; Zheng, Runhui; H, Tan; Zheng, Lianfang

doi:10.1016/j.msec.2016.06.025

Cited by 52 publications

(19 citation statements)

References 42 publications

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“… 31 pH value is one of the most important factors for studying the drug release process. 9 In this study, the release profile of MWCNT-FMN in PBS solution at pH 7.4 and 5.3 was investigated. The cumulative release rate of MWCNT-FMN reached 52.20%±1.91% within 48 hours at pH 7.4 compared with 16.38%±2.99% at pH 5.3, which could be caused by the increased solubility of FMN in aqueous solution of increasing pH values.…”

Section: Resultsmentioning

confidence: 99%

“… 7 Ever since their emergence as a nanotechnology, they have been assessed as candidates for targeted drug delivery because of their high aspect ratio and surface area, high mechanical strength, and ease of drug loading via π–π stacking interactions. 8 , 9 Many possible uses for CNTs can be found in the literature, such as drug delivery, cancer therapy, 10 thermal therapy, and tissue-targeted therapy. 11 In short, CNTs have many unique physical, chemical, and biological properties and they have been extensively explored for biological and medical applications.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells

Guo

Liao

Liu

et al. 2018

DDDT

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BackgroundThe present work was conducted to prepare and evaluate multiwalled carbon nanotube–formononetin (MWCNT-FMN) composite for sustained delivery and inducing apop-tosis via reactive oxygen species (ROS) production in HeLa cells.MethodsThe composite was prepared by solution mixing with short carboxylic group-functionalized multiwalled carbon nanotubes (MWCNT-COOH). Then the composite was characterized by laser particle size analysis, Fourier transform infrared spectrometry, X-ray diffractometry, differential scanning calorimetry, and scanning electron microscopy. Drug release rates in vitro were determined by dialysis method. The in vitro cytotoxicity study was performed using water soluble tetrazolium assay. The cellular apoptosis assay, ROS, and mitochondrial membrane potential (MMP) of HeLa cells were investigated by acridine orange and ethidium bromide double dye, 2′,7′-dichlorodihydrofluorescein diacetate, and 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide probe, respectively.ResultsThe entrapment efficiency was 28.77%±0.15%, and the loading capacity was 12.05%±0.20%. The release of MWCNT-FMN was sustained, and the cumulative release rate of formononetin (FMN) from MWCNT-COOH was higher at pH 7.4 than at pH 5.3. The in vitro cytotoxicity assay demonstrated that FMN, MWCNT-COOH, and MWCNT-FMN had no significant effects on the proliferation and viability of mouse fibroblast 3T3 cells over 48 hours, while the cell growth inhibition of the three samples showed concentration-dependent for HeLa cells. Biological assay suggested FMN and MWCNT-FMN could induce apoptosis in HeLa cells, meanwhile the cells exhibited stronger ROS signal and more depolarized MMP than that of the control group.ConclusionThese results preliminarily demonstrated that MWCNT-FMN exerted anticancer efficacy through cellular apoptosis induced by ROS-mediated mitochondrial dysfunctions in HeLa cells.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells

Guo

Liao

Liu

et al. 2018

DDDT

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“…The results indicated that all the synthesized compounds were found to be active against A549 cancer cells and showed dose-dependent cytotoxicity. Data also pointed out that amongst the synthesized compounds; compounds 8 (IC50 = 7.7 ± 0.5 µM) and 16 (IC50 = 7.3 ± 0.3 µM) showed comparable cytotoxicity in comparison with standard (paclitaxel—IC50 = 7.3 ± 0.7 µM) [ 2 , 6 , 9 , 15 , 21 , 35 , 38 ]. Compounds 7 (IC50 = 8.5 ± 0.8 µM), and 15 (8.2 ± 0.7 µM) also showed considerable activity against the cancer cell lines (Table 1 ).…”

Section: Resultsmentioning

confidence: 90%

Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies

Rathee

Lather²,

Grewal

et al. 2018

Chemistry Central Journal

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Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and angiogenesis, which suggests that creating potent MMP-2 and -9 inhibitors, should be an important goal in lung cancer therapy. In the present study, an effort has been made to develop new anti-metastatic and anti-invasive agents, wherein a series of novel diazepine substituted cinnamic acid derivatives were designed, synthesized and assayed for their inhibitory activities on MMP-2 and MMP-9. These derivatives were prepared via microwave assisted reaction of tert-butyl (3-cinnamamidopropyl)carbamate derivatives mixed with 2,3-dibromopropanoic acid and potassium carbonate was added to obtain 4-(tert-butoxycarbonyl)-1-cinnamoyl-1,4-diazepane-2-carboxylic acid derivatives. The newly synthesized compounds were characterized by IR, NMR and mass spectroscopy. All the tested compounds showed good to excellent cytotoxic potential against A549 human lung cancer cells. The active compounds displaying good activity were further examined for the inhibitory activity against MMPs (-2 and -9). In addition, the structure and anticancer activity relationship were further supported by in silico docking studies of the active compounds against MMP-2 and MMP-9.

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“…In this elementary work, carboxylated single walled carbon nanotubes (SWCNT) were chosen as the nanoparticle-mediated delivery carrier due to their intrinsic nanostructure (length-to-diameter ratio of up to 132,000,000:1), high cargo loading capacity, ultralight weight, non-immunogenic property and good chemical stability [ 18 ]. As a nanoscale platform for drug delivery, their external surfaces can be chemically functionalized with desired bioactive peptides [ 19 ], genes [ 20 ] or drugs [ 21 ], while their internal cavities can be encapsulated with bioactive molecules [ 22 ]. Furthermore, these nanomaterials are capable of transporting and translocating therapeutic molecules directly into the targeted cell cytoplasm through nanoneedle-like mechanism without inducing cellular apoptosis [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Levodopa into Biopolymer Coatings Based on Carboxylated Carbon Nanotubes for pH-Dependent Sustained Release Drug Delivery

et al. 2018

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Four drug delivery systems were formulated by non-covalent functionalization of carboxylated single walled carbon nanotubes using biocompatible polymers as coating agent (i.e., Tween 20, Tween 80, chitosan or polyethylene glycol) for the delivery of levodopa, a drug used in Parkinson’s disease. The chemical interaction between the coating agent and carbon nanotubes-levodopa conjugate was confirmed by Fourier transform infrared (FTIR) and Raman studies. The drug release profiles were revealed to be dependent upon the type of applied coating material and this could be further adjusted to a desired rate to meet different biomedical conditions. In vitro drug release experiments measured using UV-Vis spectrometry demonstrated that the coated conjugates yielded a more prolonged and sustained release pattern compared to the uncoated conjugate. Cytotoxicity of the formulated conjugates was studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using normal mouse embryonic fibroblast 3T3 cell line. Compared to the non-coated conjugate, the MTT data indicated that the coating procedure improved the biocompatibility of all systems by 34–41% when the concentration used exceeded 100 μg/mL. In conclusion, the comprehensive results of this study suggest that carbon nanotubes-based drug carrier coated with a suitable biomaterial may possibly be a potential nanoparticle system that could facilitate drug delivery to the brain with tunable physicochemical properties.

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Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes

Cited by 52 publications

References 42 publications

Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells

Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells

Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies

Incorporation of Levodopa into Biopolymer Coatings Based on Carboxylated Carbon Nanotubes for pH-Dependent Sustained Release Drug Delivery

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