Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

Xia, Wentao; Tao, Zixuan; Zhu, Bin; Zhang, Wenxiang; Liu, Chang; Chen, Siyu; Song, Mingming

doi:10.3390/ijms22179118

Cited by 88 publications

(59 citation statements)

References 235 publications

(220 reference statements)

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“… 14 Due to the breakthrough for the treatment of cancer in molecular biology, the role of molecular targeted therapy has gradually increased, and the advantages of molecularly targeted drugs with good efficacy and less toxic side effects have gradually popularized in the clinical practice. 15 …”

Section: Discussionmentioning

confidence: 99%

Effect of Gefitinib Combined with Chemotherapy in Patients with Advanced NSCLC: A Retrospective Cohort Study

Dai

Wang

et al. 2022

IJGM

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Background There are currently no methods for the treatment of reversible drug-resistant EGFR-TKI lung cancer in the clinical setting, and thus, the patients finally return to the currently used drugs. This study aimed to compare the efficacy of chemotherapy alone and gefitinib combined with chemotherapy in the treatment of non-small cell lung cancer (NSCLC) patients in advanced stage with the mutation of epidermal growth factor receptor (EGFR). Methods A retrospective analysis was carried out on 120 patients with advanced EGFRm+ NSCLC who were divided into the control group (CG, received chemotherapy alone) or the observation group (OG, received chemotherapy and gefitinib) according to the treatment methods. Results Comparison of the objective response rates (ORRs) showed no statistical significant difference between OG (36.92%) and CG (29.09%, P > 0.05), whereas in OG, disease control rate (DCR) was significantly increased in comparison with CG (P < 0.05). The medians of progression-free survival (PFS) and overall survival (OS) in OG were 8.0 months and 24.0 months, respectively, which were longer than 5.0 months and 18.0 months in CG (P = 0.031). The univariate analysis revealed that clinical stage of tumor (HR = 1.590, 95% CI: 1.097–2.343) was the prognostic factor for advanced lung cancer. Multi-factor Cox regression analysis revealed that clinical analysis was an independent prognostic factor (HR = 1.701, 95% CI: 1.099–2.632). Conclusion In PFS patients, the OS rate was significantly improved, which was worth for clinical use.

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Section: Discussionmentioning

confidence: 99%

Effect of Gefitinib Combined with Chemotherapy in Patients with Advanced NSCLC: A Retrospective Cohort Study

Dai

Wang

et al. 2022

IJGM

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“…The use of nanotechnology in drug delivery for cancer therapy has exploded in recent years [38]. Nanoparticles (NPs) have shown great potential in reducing drug toxicity and side effects; however, it has been recently recognized that carrier systems themselves may inflict damage to the patients.…”

Section: Petroleum Ether 79mentioning

confidence: 99%

Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener

et al. 2022

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Stevia rebaudiana Bertoni is a perennial shrub from Paraguay that is nowadays widely cultivated, since it is increasingly being utilized as a sugar substitute in various foodstuffs due to its sweetness and minimal caloric content. These properties of the plant’s derivatives have spurred research on their biological activities revealing a multitude of benefits to human health, including antidiabetic, anticariogenic, antioxidant, hypotensive, antihypertensive, antimicrobial, anti-inflammatory and antitumor actions. To our knowledge, no recent reviews have surveyed and reported published work solely on the latter. Consequently, our main objective was to present a concise, literature-based review of the biological actions of stevia derivatives in various tumor types, as studied in in vitro and in vivo models of the disease. With global cancer estimates suggesting a 47% increase in cancer cases by 2040 compared to 2020, the data reviewed in this article should provide a better insight into Stevia rebaudiana and its products as a means of cancer prevention and therapy within the context of a healthy diet.

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“…Notably, utilizing engineered polymers can improve and streamline CAR-T cell manufacturing process. Diverse kinds of polymers have been synthesized and modified to apply in many medical engineering processes including cell culture ( 99 ), tissue engineering ( 100 ), separation ( 101 ), and drug and gene delivery ( 102 ). Similarly, many polymeric systems have been used to optimize streamlined CAR-T cell manufacturing process, mainly focusing on activation and genetic modification of the CAR-T cell.…”

Section: Different Immunotherapies and Polymeric Systems Applying For...mentioning

confidence: 99%

Polymeric Systems for Cancer Immunotherapy: A Review

Le¹,

Yoon²,

Thambi³

et al. 2022

Front. Immunol.

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Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.

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Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

Cited by 88 publications

References 235 publications

Effect of Gefitinib Combined with Chemotherapy in Patients with Advanced NSCLC: A Retrospective Cohort Study

Effect of Gefitinib Combined with Chemotherapy in Patients with Advanced NSCLC: A Retrospective Cohort Study

Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener

Polymeric Systems for Cancer Immunotherapy: A Review

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