2018
DOI: 10.1039/c8ra07539e
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Targeted delivery of paclitaxel by functionalized selenium nanoparticles for anticancer therapy through ROS-mediated signaling pathways

Abstract: As a therapeutic anticancer agent, the clinical use of paclitaxel (PTX) is limited by its poor water solubility and serious adverse side effects.

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Cited by 8 publications
(5 citation statements)
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“…Mix MDCK cells in a 6well plate with 1 mL of JC-1 solution and incubate in an incubator at 37 °C for 20 min; then capture the fluorescence image under a fluorescence microscope. 32 2.7. Determination of ROS Generation.…”
Section: Fluorescence Real-time Pcrmentioning
confidence: 99%
“…Mix MDCK cells in a 6well plate with 1 mL of JC-1 solution and incubate in an incubator at 37 °C for 20 min; then capture the fluorescence image under a fluorescence microscope. 32 2.7. Determination of ROS Generation.…”
Section: Fluorescence Real-time Pcrmentioning
confidence: 99%
“…Currently, Se NPs have drawn significant attention as therapeutic agents [291]. There are reports describing the antitumor activity of Se NPs due to their effect on reactive oxygen species (ROS) generated inside cells [292][293][294][295][296]. Internalization of Se NPs by tumor cells increases the production of mitochondrial ROS that results in ATP depletion and consequent cell death.…”
Section: Se Npsmentioning
confidence: 99%
“…Nanoparticles are a nanotechnology tool that has been successfully applied in delivering anticancer molecules with biopharmaceutical limitations [ 10 , 11 , 12 ]. These can be used to treat cancer due to their specific advantages such as biocompatibility, reduced toxicity, enhanced permeability and retention (EPR) effect, and precise targeting [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%