Targeted delivery of rosmarinic acid across the blood–brain barrier for neuronal rescue using polyacrylamide-chitosan-poly(lactide- co -glycolide) nanoparticles with surface cross-reacting material 197 and apolipoprotein E

Kuo, Yung‐Chih; Rajesh, Rajendiran

doi:10.1016/j.ijpharm.2017.05.039

Cited by 44 publications

(18 citation statements)

References 58 publications

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“…Polyacrylamide-cardiolipin-PLGA grafted with surface 83-14 monoclonal antibody has been designed as a potential nanocarriers to deliver rosmarinic acid to the brain for protecting β-amyloid-insulted neurons [243]. Similarly, polyacrylamide-chitosan-PLGA grafted with cross-reacting material 197 and apolipoprotein E nanocarriers was found to be effective in delivering rosmarinic acid to the brain for alleviating neurotoxicity-mediated through β-amyloid [244]. Both these nanocarriers allowed rosmarinic acid to cross blood-brain barrier, improve cellular uptake, and attenuate β-amyloidosis.…”

Section: Rosmarinic Acidmentioning

confidence: 99%

“…as di-or tri-blocks has also been shown to improve the therapeutic efficacy of phytochemicals as antidiabetic agents with better pharmacokinetic attributes. PLGA-PVA, Poly(ε-caprolactone)-PLGA, pluronic-PLGA, PLGA-PEG, chitosan-PLGA, chitosan-gum arabic, chitosan-alginate, PCL-PLGA-PEG-COOH, and chitooligosaccharides-PLGA, polycaprolactone-polyethyleneimine, polyacrylamide-chitosan-PLGA, chitooligosaccharides-PLGA, and PEG-block-[poly-(ethylenediaminel-glutamate)-graft-poly-(ε-benzyloxy-carbonyl-l-lysine)] have been revealed to be attractive nanocarriers to improve pharmacokinetic profile and antidiabetic efficacy of curcumin, luteolin, silybin, thymoquinone, ferulic acid, fisetin, and astaxanthin, respectively [195,223,237,244,269,317,321]. In addition, block polymer can improve the target specificity of the nanoformulations [361].…”

Section: Interpretation and Conclusionmentioning

confidence: 99%

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Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Rosmarinic Acidmentioning

confidence: 99%

Section: Interpretation and Conclusionmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…Rosmarinic acid-loaded polyacrylamide-chitosan-poly (lactide- co -glycolide) nanoparticles were grafted with cross-reacting material 197 and apolipoprotein E to pass across the BBB and rescuing neurodegeneration. The change can be a promising formulation to deliver rosmarinic acid to insulted neurons in the pharmacotherapy of AD at the cellular level [ 101 ]. In in vitro permeation studies, a novel approach for preparation of a six-day transdermal drug delivery system as treatment for mild to moderate AD was considered as an alternative for one-week application of six Exelon patches [ 102 ].…”

Section: Biological Activity Of Cts and Cos And Its Derivatives Inmentioning

confidence: 99%

Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer’s Disease

Ouyang

Zhao

et al. 2017

Marine Drugs

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Classic hypotheses of Alzheimer’s disease (AD) include cholinergic neuron death, acetylcholine (ACh) deficiency, metal ion dynamic equilibrium disorder, and deposition of amyloid and tau. Increased evidence suggests neuroinflammation and oxidative stress may cause AD. However, none of these factors induces AD independently, but they are all associated with the formation of Aβ and tau proteins. Current clinical treatments based on ACh deficiency can only temporarily relieve symptoms, accompanied with many side-effects. Hence, searching for natural neuroprotective agents, which can significantly improve the major symptoms and reverse disease progress, have received great attention. Currently, several bioactive marine products have shown neuroprotective activities, immunomodulatory and anti-inflammatory effects with low toxicity and mild side effects in laboratory studies. Recently, chitosan (CTS), chitooligosaccharide (COS) and their derivatives from exoskeletons of crustaceans and cell walls of fungi have shown neuroprotective and antioxidative effects, matrix metalloproteinase inhibition, anti-HIV and anti-inflammatory properties. With regards to the hypotheses of AD, the neuroprotective effect of CTS, COS, and their derivatives on AD-like changes in several models have been reported. CTS and COS exert beneficial effects on cognitive impairments via inhibiting oxidative stress and neuroinflammation. They are also a new type of non-toxic β-secretase and AChE inhibitor. As neuroprotective agents, they could reduce the cell membrane damage caused by copper ions and decrease the content of reactive oxygen species. This review will focus on their anti-neuroinflammation, antioxidants and their inhibition of β-amyloid, acetylcholinesterase and copper ions adsorption. Finally, the limitations and future work will be discussed.

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“…These curcumin-PLGA-NPs have the ability to pass through the BBB and disrupt β-amyloid (Abeta) aggregates [74,75]. Recent publications suggest that PLGA-NPs functionalized with quercetin, a natural flavonoid compound, or with rosmarinic acid, a polyphenol-type carboxylic acid, may be potential candidates for AD treatment [76,77,78].…”

Section: Biodegradable Nps In Drug Delivery Systemsmentioning

confidence: 99%

Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies

Calzoni

Cesaretti²,

Polchi³

et al. 2019

JFB

359

197

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Polymer nanoparticles (NPs) represent one of the most innovative non-invasive approaches for drug delivery applications. NPs main objective is to convey the therapeutic molecule be they drugs, proteins, or nucleic acids directly into the target organ or tissue. Many polymers are used for the synthesis of NPs and among the currently most employed materials several biocompatible synthetic polymers, namely polylactic acid (PLA), poly lactic-co-glycolic acid (PLGA), and polyethylene glycol (PEG), can be cited. These molecules are made of simple monomers which are naturally present in the body and therefore easily excreted without being toxic. The present review addresses the different approaches that are most commonly adopted to synthetize biocompatible NPs to date, as well as the experimental strategies designed to load them with therapeutic agents. In fact, drugs may be internalized in the NPs or physically dispersed therein. In this paper the various types of biodegradable polymer NPs will be discussed with emphasis on their applications in drug delivery. Close attention will be devoted to the treatment of cancer, where both active and passive targeting is used to enhance efficacy and reduce systemic toxicity, and to diseases affecting the central nervous system, inasmuch as NPs can be modified to target specific cells or cross membrane barriers.

show abstract

Targeted delivery of rosmarinic acid across the blood–brain barrier for neuronal rescue using polyacrylamide-chitosan-poly(lactide- co -glycolide) nanoparticles with surface cross-reacting material 197 and apolipoprotein E

Cited by 44 publications

References 58 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer’s Disease

Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies

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