Targeted Delivery of Tanshinone IIA-Conjugated mPEG-PLGA-PLL-cRGD Nanoparticles to Hepatocellular Carcinoma

Wang, Yan; Song, Daqian; Costanza, Frankie; Ji, Guang; Fan, Zhongze; Cai, Jianfeng; Li, Qi

doi:10.1166/jbn.2014.1982

Cited by 24 publications

(9 citation statements)

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“…The results of higher cytotoxicity of DTX-NPs and DTX-LPNPs against cancer cells are in consistent with previous studies, indicating that the cytotoxicity of drug-loaded nanoparticles was higher than that of free drugs. [26,27] A possible mechanism underlying the enhanced efficacy of DTX-LPNPs against cancer cells is that liposomal nanoparticles may carry drug into the cancer cells by endocytosis and enhance intracellular drug accumulation by nanoparticles uptake. [28,29] Liposome has been applied widely because of its biomembrane-like structure and high membrane penetrating capability to increase intracellular uptake efficiency.…”

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of lipid emulsified docetaxel-loaded nanoparticles

Zhang

Chang

et al. 2015

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of lipid emulsified docetaxel-loaded nanoparticles

Zhang

Chang

et al. 2015

Journal of Pharmacy and Pharmacology

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“…34 Nanoparticles made with methoxy polyethylene glycol, polylactic-co-glycolic acid, poly-l-lysine, and cyclic arginine-glycine-aspartic acid with TIIA payload demonstrated extended TIIA releasing time, and improved hepatocellular carcinoma (HCC)-inhibitory activity. 35 Solid inclusion complexes of TIIA and TI with naturally occurring, water-soluble cyclic oligosaccharide β-cyclodextrins…”

Section: Novel Formulations To Improve Solubility and Pksmentioning

confidence: 99%

Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective

Wu¹,

Zhang²,

Tang³

et al. 2016

BTAT

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Salvia miltiorrhiza Bunge (Danshen in Chinese or Tanshen in Anglicized literature) is a well-known Traditional Chinese Medicine herbal remedy for treating cardiovascular-and cerebrovascular-related disorders. To date, .40 hydrophorbic tanshinones and structurally related compounds have been isolated from the Danshen root, as have some 50 hydrophilic phenolics and other minor components. In the past 2 decades, a large quantity of literature has reported inhibitory activities of tanshinones against cancers of various organ sites in cell culture models, and in some cases with efficacy confirmation in preclinical animal cancer models. This study follows up on a 2012 review we published on the sources, pharmacokinetics, and anticancer activities of tanshinones. Here, we update on the recent progress in understanding the anticancer potential of tanshinones and derivatives and critically assess merits of these entities for future research and development. Overall, potency data from in vivo efficacy assessment experiments in preclinical models varied from nil for chemoprevention of a prostate carcinogenesis model to strong inhibition of some xenograft or allograft models. Lack of uniformity of excipients, doses, and routes of administration aside, we caution that the reviewed data should be appreciated in balance of publication bias exemplified by our own data from primary carcinogenesis study and false positivity. Novel formulations and chemical modifications had been made to improve the poor solubility and bioavailability of tanshinones. Human clinical studies so far dealt with case reports of tanshinone IIA use and small-scale trials on Danshen-containing formulas with chemotherapy for cancers of multiple organ sites in People's Republic of China. Available human data are not sufficient for supporting any anticancer indication of tanshinones.

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“…Active targeting nanoparticles have been shown in various studies to be more efficient in increasing drug accumulation in cancer cells and therefore play important role not only in modern cancer chemotherapy, but also in cancer therapy with traditional/ herbal medicines. [6][7][8][9][10][11] A number of nanoparticle formulations derived from these active compounds have been developed for active targeting purpose to improve anticancer efficacy and to reduce side effects. The objective of this current review is to summarize the research articles relating to the application of active targeting nanoparticles delivering system for chemotherapeutic drugs derived from chemical synthesis as well as natural sources.…”

Section: Introductionmentioning

confidence: 99%

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

Muhamad

Plengsuriyakarn²,

Na‐Bangchang³

2018

IJN

331

153

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Patients treated with conventional cancer chemotherapy suffer from side effects of the drugs due to non-selective action of chemotherapeutic drugs to normal cells. Active targeting nanoparticles that are conjugated to targeting ligands on the surface of nanoparticles play an important role in improving drug selectivity to the cancer cell. Several chemotherapeutic drugs and traditional/herbal medicines reported for anticancer activities have been investigated for their selective delivery to cancer cells by active targeting nanoparticles. This systematic review summarizes reports on this application. Literature search was conducted through PubMed database search up to March 2017 using the terms nanoparticle, chemotherapy, traditional medicine, herbal medicine, natural medicine, natural compound, cancer treatment, and active targeting. Out of 695 published articles, 61 articles were included in the analysis based on the predefined inclusion and exclusion criteria. The targeting ligands included proteins/peptides, hyaluronic acid, folic acid, antibodies/antibody fragments, aptamer, and carbohydrates/polysaccharides. In vitro and in vivo studies suggest that active targeting nanoparticles increase selectivity in cellular uptake and/or cytotoxicity over the conventional chemotherapeutic drugs and non-targeted nanoparticle platform, particularly enhancement of drug efficacy and safety. However, clinical studies are required to confirm these findings.

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Targeted Delivery of Tanshinone IIA-Conjugated mPEG-PLGA-PLL-cRGD Nanoparticles to Hepatocellular Carcinoma

Cited by 24 publications

References 0 publications

Preparation and evaluation of lipid emulsified docetaxel-loaded nanoparticles

Preparation and evaluation of lipid emulsified docetaxel-loaded nanoparticles

Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

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