Targeted delivery of TNF using NGR-TNF in combination with chemotherapy as an effective and tolerable strategy in a hepatocarcinoma patient

Abstract

Targeted delivery of TNF to tumour vessels has been achieved by coupling this protein with the CNGRC peptide, an aminopeptidase N (CD13) ligand that targets the tumour neovasculature.Th e so-called NGR-TNF enhances the penetration of chemotherapeutic drugs in tumours and improves their effi cacy. Here we describe a case of hepatocarcinoma which showed response to NGR-hTNF in combination with doxorubicin, clinically proving this promising strategy.