Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling

Targeted dephosphorylation of TFEB promotes its nuclear translocation

“…We have shown its utility in targeted dephosphorylation through induced proximity between bromoTAG-PPP2CA and TFEB-dTAG here, as well as dTAG-SMAD3 and bromoTAG-PPM1H. 60 In principle, BDPIC could be applied to induce proximity between any two proteins inside cells. The molecule offers an excellent platform to test whether modulating any of the more than 500 protein post-translational modifications on target proteins by recruiting the modifying enzymes in proximity affects the target protein function.…”