Targeted Drug Delivery: Mannose and Mannose‐6‐Phosphate Receptor–Targeted Drug Delivery Systems and Their Application in Cancer Therapy (Adv. Healthcare Mater. 14/2018)

Therapeutic Targeting of Lung Adenocarcinoma with Mannose-Coated Chitosan/Copper Nanocluster–Levocetirizine Nanocomposite

“…It has been reported that mannose receptor is overexpressed in the A549 cell line compared to the HeLa and HEK-293 cell lines. , Most tumor cells often have higher metabolic demand than their normal counterparts. Therefore, overexpression of receptors such as that of mannose can increase their sensitivity for monosaccharides. , Therefore, the mannose coating over chitosan was aimed at targeting the overexpressed mannose receptors on the surface of A549 cells. Consecutively, the higher intensity of red fluorescence in A549 cells showed preferential uptake of the nanocomposites after incubation, as compared with HeLa cells.…”

Targeted protein degradation directly engaging lysosomes or proteasomes

“…110 In addition, it functions as a decoy receptor, continuously shuttling M6P-modified cargoes from the plasma membrane to the endosomal compartments. [111][112][113][114] In late endosomes and lysosomes, the low pH induces the dissociation of the endocytosed CI-M6PR and LYTAC-target complex and facilitates receptor recycling, while the target proteins are degraded in the lysosome. 50 To generate glycopolypeptides that are not only recognised by CI-M6PR but are also resistant to cellular phosphatase activity, Banik et al synthesised N-carboxyanhydride (NCA)derived Ser-Ala polypeptides (with various lengths) containing multiple serine-O-mannose-6-phosphonate moieties (M6Pn) (Table 1).…”

Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells

“…TNBC cells are characterized by the lack of the expression of specific targetable receptors that are commonly found in other types of BC. Accordingly, the GLUT channel 18,19 and the mannose receptor 20 were selected in this work as targets widely overexpressed in various tumor types including TNBC. First, we enhanced the colloidal stability of our hybrid glyconanomaterial by increasing the sulphation degree of the pristine CNC, obtaining the CNC* (Fig.…”