Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects

Sanak, Marek; Gielicz, Anna; Nagraba, Krzysztof; Kaszuba, Marek; Kumik, Jagoda; Szczeklik, A

doi:10.1016/j.jchromb.2010.05.012

Cited by 61 publications

(65 citation statements)

References 22 publications

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“…Using an analytic approach based on mass spectrometry of EBC, subjects with AERD were distinguished by a sharp increase in the level of prostaglandin D2 and E2 metabolites. 5-and 15-HETE levels were also higher compared to aspirin-tolerant asthma (55). Still, none of these tests is able to reliably diagnose AERD, and the observed quantitative differences might be related to the higher intrinsic inflammation observed in patients with intrinsic asthma and aspirin sensitivity.…”

Section: Aspirin-intolerant Asthmamentioning

confidence: 92%

Untangling asthma phenotypes and endotypes

Agache

Akdiş

Jutel

et al. 2012

Allergy

292

235

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Asthma phenotypes have been developed to address the complexities of the disease. However, owing to a lack of longitudinal studies, little is known about the onset as well as the stability of phenotypes. Distinguishing phenotypes with regard to the severity or duration of the disease is essential. A phenotype covers the clinically relevant properties of the disease, but does not show the direct relationship to disease etiology and pathophysiology. Different pathogenetic mechanisms might cause similar asthma symptoms and might be operant in a certain phenotype. These putative mechanisms are addressed by the term 'endotype'. Classification of asthma based on endotypes provides advantages for epidemiological, genetic, and drug-related studies. A successful definition of endotypes should link key pathogenic mechanisms with the asthma phenotype. Thus, the identification of corresponding molecular biomarkers for individual pathogenic mechanism underlying phenotypes or subgroups within a phenotype is important. Whether newly defined asthma endotypes predict the individual course of asthma has to be validated in longitudinal studies. The accurate endotyping reflects natural history of asthma and should help to predict treatment response. Thus, understanding asthma endotypes might be useful in clinical practice.

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Section: Aspirin-intolerant Asthmamentioning

confidence: 92%

Untangling asthma phenotypes and endotypes

Agache

Akdiş

Jutel

et al. 2012

Allergy

292

235

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“…Concentration of measured compounds was calculated using a stable isotope method from the area under the peak of the breakdown of ion abundance. Further details of the method have been published elsewhere[21,22].…”

mentioning

confidence: 99%

Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes

Polus

Kieć‐Wilk

Raźny

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Therefore we applied our own analytic approach based on mass spectrometry. 8 This recently developed approach has allowed us to assess a vast platform of eicosanoids in different asthma phenotypes.…”

mentioning

confidence: 99%

Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype

Sanak

Gielicz

Bochenek

et al. 2011

Journal of Allergy and Clinical Immunology

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The highly sensitive eicosanoid profiling in EBC makes it possible to detect alterations in asthma, especially in its distinct phenotype characterized by hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs. This permits us to discriminate asthmatic subjects from healthy subjects, as well as to distinguish the 2 asthma phenotypes based on the presence or absence of aspirin hypersensitivity.

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Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects

Cited by 61 publications

References 22 publications

Untangling asthma phenotypes and endotypes

Untangling asthma phenotypes and endotypes

Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes

Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype

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