Targeted Fe-filled carbon nanotube as a multifunctional contrast agent for thermoacoustic and magnetic resonance imaging of tumor in living mice

Ding, Wenzheng; Lou, Cunguang; Qiu, Jieshan; Zhao, Zongbin; Zhou, Quan; Liang, Minjie; Ji, Zhong; Yang, Sihua; Xing, Da

doi:10.1016/j.nano.2015.08.008

Cited by 35 publications

(21 citation statements)

References 33 publications

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“…optical absorption coefficient for light source, or effective conductivity for microwave, even imaginary permeability for magnetic illumination. Majority of the previous work in contrast agents and thin film design are focused on EM absorption improvement [43], [44]. Thermal expansion coefficient of the surrounding medium : The thermal expansion coefficient determines how much displacement could be generated from specific temperature rise. Therefore, it is closely related with the PA/TA generation efficiency from EM absorption to thermoelastic vibration.…”

Section: Simulation Resultsmentioning

confidence: 99%

An analytical study of photoacoustic and thermoacoustic generation efficiency towards contrast agent and film design optimization

et al. 2017

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Photoacoustic (PA) and thermoacoustic (TA) effects have been explored in many applications, such as bio-imaging, laser-induced ultrasound generator, and sensitive electromagnetic (EM) wave film sensor. In this paper, we propose a compact analytical PA/TA generation model to incorporate EM, thermal and mechanical parameters, etc. From the derived analytical model, both intuitive predictions and quantitative simulations are performed. It shows that beyond the EM absorption improvement, there are many other physical parameters that deserve careful consideration when designing contrast agents or film composites, followed by simulation study. Lastly, several sets of experimental results are presented to prove the feasibility of the proposed analytical model. Overall, the proposed compact model could work as a clear guidance and predication for improved PA/TA contrast agents and film generator/sensor designs in the domain area.

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Section: Simulation Resultsmentioning

confidence: 99%

An analytical study of photoacoustic and thermoacoustic generation efficiency towards contrast agent and film design optimization

et al. 2017

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“…Carbon nanomaterials have been found to be an excellent scaffold for contrast agents since they can be used to carry imaging agents, such as fluorescent labels and radionuclides, contributing to the generation of high-quality images and the early detection of breast cancer [20,21,49,[56][57][58]. Experiments have demonstrated that CNT can carry imaging agents [57] and demonstrated great potential of using functionalized MWCNT as efficient cell probes for MRI [59].…”

Section: Contrast Agentmentioning

confidence: 99%

“…Many properties of carbon nanomaterials, such as size, shape, surface structure and charge, chemical composition, aggregation and/or agglomeration, and solubility, can greatly influence their interactions with biomolecules and cells. For example, carbon nanomaterials have been employed to produce exceptional images of tumor sites [20,21], impressive potential as high-efficiency delivery transporters for drugs and/or biomolecules into cells [20,22,23]. Therefore, the main emphasis of this article focuses on the discussion of carbon nanomaterials and their current applications in the identification, diagnosis, and treatment of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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Currently, breast cancer is considered as a health problem worldwide. Furthermore, current treatments neither are capable of stopping its propagation and/or recurrence nor are specific for cancer cells. Therefore, side effects on healthy tissues and cells are common. An increase in the efficiency of treatments, along with a reduction in their toxicity, is desirable to improve the life quality of patients affected by breast cancer. Nanotechnology offers new alternatives for the design and synthesis of nanomaterials that can be used in the identification, diagnosis, and treatment of cancer and has now become a very promising tool for its use against this disease. Among the wide variety of nanomaterials, the scientific community is particularly interested in carbon nanomaterials (fullerenes, nanotubes, and graphene) due to their physical properties, versatile chemical functionalization, and biocompatibility. Recent scientific evidence shows the potential uses of carbon nanomaterials as therapeutic agents, systems for selective and controlled drug release, and contrast agents for diagnosing and locating tumors. This generates new possibilities for the development of innovative systems to treat breast cancer and can be used to detect this disease at much earlier stages. Thus, applications of carbon nanomaterials in breast cancer treatment are discussed in this article.

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“…Moreover, long Fe nanowires can be formed in the inner cavity of MWNTs under control during the nanotube synthesis process. Through surface functionalization (with folic acids), the MWNTs encapsulating Fe-nanowires can cause a strong decrease in T2 MRI signals by four-fifths, compared to MWNTs without the inner-encapsulated Fe nanowires [ 45 ]. Torti et al explored the dose effect of the magnetic catalyst and found that the in vivo r2 relaxivity of the as-grown MWNTs increased with the mass content of the catalyst within the studied range, which maximized at 2.92% Fe [ 46 ].…”

Section: Cnt-mnp Hybrid Mri Contrast Agentsmentioning

confidence: 99%

Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications

Gao

2018

JFB

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Magnetic resonance imaging (MRI) is the most powerful tool for deep penetration and high-quality 3D imaging of tissues with anatomical details. However, the sensitivity of the MRI technique is not as good as that of the radioactive or optical imaging methods. Carbon-based nanomaterials have attracted significant attention in biomaterial research in recent decades due to their unique physical properties, versatile functionalization chemistry, as well as excellent biological compatibility. Researchers have employed various carbon nano-allotropes to develop hybrid MRI contrast agents for improved sensitivity. This review summarizes the new research progresses in carbon-based hybrid MRI contrast agents, especially those reported in the past five years. The review will only focus on T2-weighted MRI agents and will be categorized by the different carbon allotrope types and magnetic components. Considering the strong trend in recent bio-nanotechnology research towards multifunctional diagnosis and therapy, carbon-based MRI contrast agents integrated with other imaging modalities or therapeutic functions are also covered.

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Targeted Fe-filled carbon nanotube as a multifunctional contrast agent for thermoacoustic and magnetic resonance imaging of tumor in living mice

Cited by 35 publications

References 33 publications

An analytical study of photoacoustic and thermoacoustic generation efficiency towards contrast agent and film design optimization

An analytical study of photoacoustic and thermoacoustic generation efficiency towards contrast agent and film design optimization

Carbon Nanomaterials for Breast Cancer Treatment

Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications

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