The Athabasca Basin in Canada (Figure 1) is the premier exploration region for uranium deposits, hosting the highest grade deposits in the world (Jefferson et al., 2007). Traditionally, uranium deposits in the eastern Athabasca Basin region occur within 400 m of the basin-basement unconformity surface and are associated with graphite-rich faults rooted in metapelitic gneisses (Jefferson et al., 2007 and references therein). The Patterson Lake corridor (PLC) in the western Athabasca Basin hosts the high-grade Triple R and Arrow uranium deposits and several prospects such as Spitfire, Cannon, Arrow South and Harpoon. However, the known PLC deposits do not occur in geological settings typical of unconformity-related uranium (URU) deposits (Jefferson et al., 2007); they are hosted in altered, metamorphosed granite, granodiorite and ultramafic to mafic basement rocks up to 900 m below the unconformity contact, and in some cases, outside the present-day basin margins. The fluid-conduits for PLC deposits are reactivated fault zones rich in hydrothermal graphite and sulfide minerals. Recent geochemical and thermochronology studies of the PLC district suggest a deep, fertile heat source enhanced hydrothermal fluid flow and mineralogical, fluid inclusion, isotopic and structural studies document incursion of basinal brines to ∼1 km depth along inherited ductile fault zones reactivated under a brittle regime (