Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet

Ji, Ding‐Kun; Zhang, Yue; Zang, Yi; Li, Jia; Chen, Guorong; He, Xiao‐Peng; Tian, He

doi:10.1002/adma.201602748

Cited by 111 publications

(77 citation statements)

References 52 publications

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“…Within them, DCM‐galactose and coumarin‐mannose on GO were used for the simultaneous detection of PNA/Con A with a single excitation and dual emission . 2D MoS 2 was used along with GO to load a DCM‐galactose probe for staining Hep‐G2 cells and imaging intracellular ROS production . The imaging abilities of GO and MoS 2 were measured, and indicated that MoS 2 significantly enhanced fluorescence imaging compared to GO (Figure 18c).…”

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging‐guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target‐based theranostic materials.

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Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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“…Due to the intrinsic ROS‐producing ability of photosensitizers through light irradiation, PDT (photodynamic therapy) has been developed as a noninvasive strategy for disease therapy . Smart drug delivery systems that can produce ROS under light illumination, and release therapeutic agents in response to the ROS produced, have been developed.…”

Section: Ros‐activated Drug Delivery and Small‐molecular Prodrug Systemsmentioning

confidence: 99%

“…Smart drug delivery systems that can produce ROS under light illumination, and release therapeutic agents in response to the ROS produced, have been developed. These systems are based on the loading of known photosensitizers (which could produce 1 O 2 ) into nanoparticles, resulting in combined chemo‐ and photodynamic therapy when coloaded with drugs …”

Section: Ros‐activated Drug Delivery and Small‐molecular Prodrug Systemsmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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“…These strongly fluorescent nanosheets can be internalized within cells, demonstrating potential applications as a cell‐targeted labeling agent . Furthermore, the cellular uptake efficacy could be further improved by conjugation of specific targeting groups . Recently, it was found that agonist‐induced activation and endocytosis of G protein‐coupled receptors (GPCRs) are significant for numerous physiological and pathological processes.…”

Section: Interactions Between Other 2d Materials and Biointerfacesmentioning

confidence: 99%

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

et al. 2018

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2D nanomaterials, particularly graphene, offer many fascinating physicochemical properties that have generated exciting visions of future biological applications. In order to capitalize on the potential of 2D nanomaterials in this field, a full understanding of their interactions with biointerfaces is crucial. The uptake pathways, toxicity, long-term fate of 2D nanomaterials in biological systems, and their interactions with the living systems are fundamental questions that must be understood. Here, the latest progress is summarized, with a focus on pathogen, mammalian cell, and tissue interactions. The cellular uptake pathways of graphene derivatives will be discussed, along with health risks, and interactions with membranes-including bacteria and viruses-and the role of chemical structure and modifications. Other novel 2D nanomaterials with potential biomedical applications, such as transition-metal dichalcogenides, transition-metal oxide, and black phosphorus will be discussed at the end of this review.

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Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet

Cited by 111 publications

References 52 publications

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

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