Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects

Liu, Liyan; Feng, Rennan; Guo, Fuchuan; Li, Ying; Jiao, Jundong; Sun, Changhao

doi:10.1016/j.diabres.2015.01.014

Cited by 48 publications

(38 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, abnormal amino acid metabolism, as indicated by elevated levels of BCAAs, approved the condition of insulin resistance when hepatocytes were exposed to excess FFA. Similar data were consistently observed in obesity and diabetes studies . Interestingly, we found that Se did not affect the insulin sensitivity and abnormal amino acid metabolism.…”

Section: Discussionsupporting

confidence: 91%

Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes

Zhang

Jiang

et al. 2017

Mol. Nutr. Food Res.

View full text Add to dashboard Cite

Although Se had the capability of preventing the apoptosis initiated by ROS, insulin resistance failed to be reversed in hepatocytes exposed to FFA. This failure may be attributed to the limitation of Se in regulating branched chain amino acids abundance. This indicates that apoptosis and insulin resistance might be involved in different pathways when isolated hepatocytes were exposed to FFA and Se.

show abstract

Section: Discussionsupporting

confidence: 91%

Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes

Zhang

Jiang

et al. 2017

Mol. Nutr. Food Res.

View full text Add to dashboard Cite

show abstract

“…The included studies were published between 2009 and 2016. Seven studies were conducted in the United States [12, 14, 20–24], four studies were from Finland [25–28], three studies were from China [29–31], two studies were from Canada [32, 33] and Japan [34, 35], and one study was from each of the following countries: UK [36], Korea [37], Singapore [38], Germany [15], and Mexico [39]. The studies varied in sample size from 30 to 7098 with a median of 873.…”

Section: Resultsmentioning

confidence: 99%

“…The studies varied in sample size from 30 to 7098 with a median of 873. There were seventeen studies enrolling both males and females, and two studies focused on women only [26, 32], while the rest of the four studies address novel findings from males [31, 36–38]. The age of participants in our studies ranged from 18 to 59 years.…”

Section: Resultsmentioning

confidence: 99%

The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review

Zhao

Han

Liu

et al. 2016

Journal of Diabetes Research

126

106

View full text Add to dashboard Cite

Recent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients. However, results seem to be controversial in different races, diets, and distinct tissues. Our aims were to evaluate the relationship between BCAA and IR as well as later diabetes risk and explore the phenotypic and genetic factors influencing BCAA level based on available studies. We performed systematic review, searching MEDLINE, EMASE, ClinicalTrials.gov, the Cochrane Library, and Web of Science from inception to March 2016. After selection, 23 studies including 20,091 participants were included. Based on current evidence, we found that BCAA is a useful biomarker for early detection of IR and later diabetic risk. Factors influencing BCAA level can be divided into four parts: race, gender, dietary patterns, and gene variants. These factors might not only contribute to the elevated BCAA level but also show obvious associations with insulin resistance. Genes related to BCAA catabolism might serve as potential targets for the treatment of IR associated metabolic disorders. Moreover, these factors should be controlled properly during study design and data analysis. In the future, more large-scale studies with elaborate design addressing BCAA and IR are required.

show abstract

“…Elevated plasma triglyceride (TG) or free fatty acid (FFA) are recognized risk factors of diabetes, because of their actions on insulin sensitivity in peripheral tissues5678910111213. In plasma, fatty acid (FA) molecules are bound to albumin molecules and become water-soluble.…”

mentioning

confidence: 99%

TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance

Yang

Zheng

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Persistent elevation of plasma TNF-α is a marker of low grade systemic inflammation. Palmitic acid (PA) is the most abundant type of saturated fatty acid in human body. PA is bound with albumin in plasma and could not pass through endothelial barrier freely. Albumin-bound PA has to be transported across monolayer endothelial cells through intracellular transcytosis, but not intercellular diffusion. In the present study, we discovered that TNF-α might stimulate PA transcytosis across cardiac microvascular endothelial cells, which further impaired the insulin-stimulated glucose uptake by cardiomyocytes and promoted insulin resistance. In this process, TNF-α-stimulated endothelial autophagy and NF-κB signaling crosstalk with each other and orchestrate the whole event, ultimately result in increased expression of fatty acid transporter protein 4 (FATP4) in endothelial cells and mediate the increased PA transcytosis across microvascular endothelial cells. Hopefully the present study discovered a novel missing link between low grade systemic inflammation and insulin resistance.

show abstract

Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects

Cited by 48 publications

References 30 publications

Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes

Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes

The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review

TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance

Contact Info

Product

Resources

About