Targeted metabolomics combined with network pharmacology to reveal the protective role of luteolin in pulmonary arterial hypertension

Song, Kexin; Duan, Qingya; Ren, Jiping; Yi, Jie; Yu, Hong; Che, Haixia; Yang, Chunjuan; Wang, Xiaotong; Li, Qian

doi:10.1039/d2fo01424f

Cited by 11 publications

(1 citation statement)

References 38 publications

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“…Treatment with luteolin, a dietary supplement, returned the altered arachidonic acid, amino acids, and tricarboxylic acid cycle levels close to normal. Luteolin partially reversed the adverse pulmonary vascular remodeling in PAH rats by blocking the excessive and rapid increase in the number of pulmonary artery smooth muscle cells [58].…”

Section: Pah Pathogenesismentioning

confidence: 93%

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Bassareo,

D’Alto

2023

IJMS

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Pulmonary hypertension (PH) is a multifaceted illness causing clinical manifestations like dyspnea, fatigue, and cyanosis. If left untreated, it often evolves into irreversible pulmonary arterial hypertension (PAH), leading to death. Metabolomics is a laboratory technique capable of providing insights into the metabolic pathways that are responsible for a number of physiologic or pathologic events through the analysis of a biological fluid (such as blood, urine, and sputum) using proton nuclear magnetic resonance spectroscopy or mass spectrometry. A systematic review was finalized according to the PRISMA scheme, with the goal of providing an overview of the research papers released up to now on the application of metabolomics to PH/PAH. So, eighty-five papers were identified, of which twenty-four concerning PH, and sixty-one regarding PAH. We found that, from a metabolic standpoint, the hallmarks of the disease onset and progression are an increase in glycolysis and impaired mitochondrial respiration. Oxidation is exacerbated as well. Specific metabolic fingerprints allow the characterization of some of the specific PH and PAH subtypes. Overall, metabolomics provides insights into the biological processes happening in the body of a subject suffering from PH/PAH. The disarranged metabolic pathways underpinning the disease may be the target of new therapeutic agents. Metabolomics will allow investigators to make a step forward towards personalized medicine.

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Section: Pah Pathogenesismentioning

confidence: 93%

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Bassareo,

D’Alto

2023

IJMS

View full text Add to dashboard Cite

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Exploration of the molecular mechanism of tea polyphenols against pulmonary hypertension by integrative approach of network pharmacology, molecular docking, and experimental verification

Yang

Cao

et al. 2023

Mol Divers

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Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism

Long,

Zhou,

et al. 2024

Chinese Herbal Medicines

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Targeted metabolomics combined with network pharmacology to reveal the protective role of luteolin in pulmonary arterial hypertension

Abstract: Luteolin protects from PAH by affecting metabolites and regulatory enzymes’ gene and protein levels in the arachidonic acid pathway.

Cited by 11 publications

References 38 publications

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Exploration of the molecular mechanism of tea polyphenols against pulmonary hypertension by integrative approach of network pharmacology, molecular docking, and experimental verification

Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism

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