Targeted Molecular Therapeutic Options for Hepatocellular Carcinoma

Sridhar, Swathi; Sharma, Ishna; Sankpal, Umesh T.; Ghabach, Bassam; Narra, Kalyani; Neerukonda, Latha; Basha, Riyaz

doi:10.1615/critrevoncog.2020034985

Cited by 3 publications

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“…Hepatocellular carcinoma is the fourth leading cause of cancer-related death in the world, with an estimated incidence of over 1 million by 2025 [ 1 , 2 ]. Compared with traditional chemotherapy, targeted therapy has a better survival rate and fewer side effects in patients with intermediate–advanced liver cancer [ 3 ]. However, due to the high heterogeneity of the tumor, the drug will gradually lose its effect.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway

Liu

Hu²,

et al. 2023

Cancers

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Hepatocellular carcinoma (HCC) is one of the most common cancers and the fourth leading cause of death in men. YEATS domain containing 2 (YEATS2) gene encodes a scaffolding subunit of the ATAC complex. We found that YEATS2 was upregulated in HCC tissues and was associated with a poor prognosis. However, the role of YEATS2 in HCC remains unclear. The purpose of this study was to investigate the effect of YEATS2 on the progression of HCC and to elucidate its related mechanisms. We found that overexpression of YEATS2 promoted tumor cell proliferation, migration, and invasion through the PI3K/AKT signaling pathway and regulation of extracellular matrix. These findings help to understand the role of YEATS2 in HCC, and YEATS2 may become a new target for HCC therapy.

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Section: Introductionmentioning

confidence: 99%

Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway

Liu

Hu²,

et al. 2023

Cancers

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High expression of YEATS2 as a predictive factor of poor prognosis in patients with hepatocellular carcinoma

Du,

Yi,

Wang

et al. 2024

Sci Rep

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Apoptotic Effect of Isoimpertorin via Inhibition of c-Myc and SIRT1 Signaling Axis

Ko,

Park,

Sim

et al. 2024

IJMS

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Though Isoimperatorin from Angelicae dahuricae is known to have antiviral, antidiabetic, anti-inflammatory and antitumor effects, its underlying antitumor mechanism remains elusive so far. Hence, the apoptotic mechanism of Isoimperatorin was explored in hepatocellular carcinomas (HCCs). In this study, Isoimperatorin inhibited the viability of Huh7 and Hep3B HCCs and increased the subG1 apoptotic portion and also abrogated the expression of pro-poly-ADP ribose polymerase (pro-PARP) and pro-caspase 3 in Huh7 and Hep3B cells. Also, Isoimperatorin abrogated the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6 and increased p21 as G1 phase arrest-related proteins in Huh7 and Hep3B cells. Interestingly, Isoimperatorin reduced the expression and binding of c-Myc and Sirtuin 1 (SIRT1) by Immunoprecipitation (IP), with a binding score of 0.884 in Huh7 cells. Furthermore, Isoimperatorin suppressed the overexpression of c-Myc by the proteasome inhibitor MG132 and also disturbed cycloheximide-treated c-Myc stability in Huh7 cells. Overall, these findings support the novel evidence that the pivotal role of c-Myc and SIRT1 is critically involved in Isoimperatorin-induced apoptosis in HCCs as potent molecular targets in liver cancer therapy.

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Targeted Molecular Therapeutic Options for Hepatocellular Carcinoma

Cited by 3 publications

References 0 publications

Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway

Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway

High expression of YEATS2 as a predictive factor of poor prognosis in patients with hepatocellular carcinoma

Apoptotic Effect of Isoimpertorin via Inhibition of c-Myc and SIRT1 Signaling Axis

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