Targeted multimodal imaging modalities

Lee, Seung Yong; Jeon, Sejin; Jung, Seulhee; Chung, In Jae; Ahn, Cheol Hee

doi:10.1016/j.addr.2014.07.009

Cited by 127 publications

(93 citation statements)

References 137 publications

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“…23,24 Earlier studies conducted with Fe-bLf NCs nanotherapeutics showed a multifunctional nature in terms of modulation of critical anticancersignaling nodes, boosting the immunosignaling mechanism by enriching the production of B cells, natural killer cells, and interleukin expression. Furthermore, Fe-bLf and Fe-bLf nanoformulations showed increased cytokine expression, promoting macrophage and phagocytic activity.…”

Section: Resultsmentioning

confidence: 99%

“…Cellular internalization mechanisms of Fe-bLf have been extensively investigated, and are mainly promoted via LRP1 and -2, DMT1, and transferrin receptors. 10,24,27 Absorption of zinc can also be promoted via zinc-specific receptors 29 and DMT1. [30][31][32] Therefore, understanding the in vivo internalization mechanisms of Zn-Fe-bLf NCs is a goal for the future.…”

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confidence: 99%

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Theranostic multimodular potential of zinc-doped ferrite-saturated metal-binding protein-loaded novel nanocapsules in cancers

Kamalapuram

Kanwar

Roy

et al. 2016

IJN

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The present study successfully developed orally deliverable multimodular zinc (Zn) iron oxide (Fe 3 O 4 )-saturated bovine lactoferrin (bLf)-loaded polymeric nanocapsules (NCs), and evaluated their theranostic potential (antitumor efficacy, magnetophotothermal efficacy and imaging capability) in an in vivo human xenograft CpG-island methylator phenotype (CIMP)-1 + /CIMP2 − /chromosome instability-positive colonic adenocarcinoma (Caco2) and claudin-low, triple-negative (ER − /PR − /HER2 − ; MDA-MB-231) breast cancer model. Mice fed orally on the Zn-Fe-bLf NC diet showed downregulation in tumor volume and complete regression in tumor volume after 45 days of feeding. In human xenograft colon cancer, vehicle-control NC diet-group (n=5) mice showed a tumor volume of 52.28±11.55 mm 3 , and Zn-Fe-bLf NC diet (n=5)-treated mice had a tumor-volume of 0.10±0.073 mm 3 . In the human xenograft breast cancer model, Zn-Fe-bLf NC diet (n=5)-treated mice showed a tumor volume of 0.051±0.062 mm 3 within 40 days of feeding. Live mouse imaging conducted by near-infrared fluorescence imaging of Zn-Fe-bLf NCs showed tumor site-specific localization and regression of colon and breast tumor volume. Ex vivo fluorescence-imaging analysis of the vital organs of mice exhibited sparse localization patterns of Zn-Fe-bLf NCs and also confirmed tumor-specific selective localization patterns of Zn-Fe-bLf NCs. Dual imaging using magnetic resonance imaging and computerized tomography scans revealed an unprecedented theranostic ability of the Zn-Fe-bLf NCs. These observations warrant consideration of multimodular Zn-Fe-bLf NCs for real-time cancer imaging and simultaneous cancer-targeted therapy.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Theranostic multimodular potential of zinc-doped ferrite-saturated metal-binding protein-loaded novel nanocapsules in cancers

Kamalapuram

Kanwar

Roy

et al. 2016

IJN

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“…Using PET images, uptake of the radionuclides in tissues of interest can be determined quantitatively, which remains a challenge for (clinical) SPECT images due to the low resolution of these images. Both SPECT and PET can be combined with other modalities, such as computed tomography (CT) or magnetic resonance imaging to obtain additional anatomical information [33]. Here, we focus on imaging of radiolabeled liposomes using SPECT and PET.…”

Section: Radionuclide Imagingmentioning

confidence: 99%

Radionuclide imaging of liposomal drug delivery

Geest

Laverman

Metselaar

et al. 2016

Expert Opinion on Drug Delivery

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Introduction: Ever since their discovery, liposomes have been radiolabeled to monitor their fate in vivo. Despite extensive preclinical studies, only a limited number of radiolabeled liposomal formulations have been examined in patients. Since they can play a crucial role in patient management, it is of importance to enable translation of radiolabeled liposomes into the clinic.Areas covered: Liposomes have demonstrated substantial advantages as drug delivery systems and can be efficiently radiolabeled. Potentially, radiolabeled drug-loaded liposomes form an elegant theranostic system, which can be tracked in vivo using single-photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. In this review, we discuss important aspects of liposomal research with a focus on the use of radiolabeled liposomes and their potential role in drug delivery and monitoring therapeutic effects. Expert opinion: Radiolabeled drug-loaded liposomes have been poorly investigated in patients and no radiolabeled liposomes have been approved for use in clinical practice. Evaluation of the risks, pharmacokinetics, pharmacodynamics and toxicity is necessary to meet pharmaceutical and commercial requirements. It remains to be demonstrated whether the results found in animal studies translate to humans before radiolabeled liposomes can be implemented into clinical practice. ARTICLE HISTORY

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“…Consequently, selection of the tracking method should be based on the distinct features of the nanocarriers as well as the specific aims of the experiments [54,55]. Here, this section introduces a simple fluorescent method that is conveniently applied for tracking vaccine delivery system.…”

Section: In Vivo Tracking Of the Ag-loaded Liposomes After Vaccinationmentioning

confidence: 99%

Liposomes Used as a Vaccine Adjuvant-Delivery System

Wang¹,

Wu²,

Wang³

2017

Liposomes

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Liposomes, a kind of bilayered vesicles formed by self-assembly of phospholipid molecules in an aqueous medium, are widely used as a vehicle for delivering various therapeutic agents due to their high biocompatibility, diverse and high-loading capacity, and relative ease for preparation and surface decoration to engender multifunctional features. Also, liposomes are a useful carrier for delivering vaccine antigens forming a versatile vaccine adjuvant-delivery system (VADS), which can efficiently fulfill both functions of adjuvancy and delivery when the liposomes are modified with specific functional molecules, such as lipoidal immunopotentiators, antigen-presenting cell (APC) targeting ligands, steric stabilization polymers and charged lipids. In this chapter, liposomes used as a VADS are introduced, including the preparation processes for liposomes, the evaluation methods toward different immunological responses, and also the measures for tracking in vivo of the vaccine-carrying liposomes, to provide reader with wide information as a reference related to the liposomal VADS.

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Targeted multimodal imaging modalities

Cited by 127 publications

References 137 publications

Theranostic multimodular potential of zinc-doped ferrite-saturated metal-binding protein-loaded novel nanocapsules in cancers

Theranostic multimodular potential of zinc-doped ferrite-saturated metal-binding protein-loaded novel nanocapsules in cancers

Radionuclide imaging of liposomal drug delivery

Liposomes Used as a Vaccine Adjuvant-Delivery System

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