Targeted nanomedicine for prostate cancer therapy: docetaxel and curcumin co-encapsulated lipid–polymer hybrid nanoparticles for the enhanced anti-tumor activityin vitroandin vivo

Abstract

Chinese medicine is one nano-sized drug delivery system promising to generate synergistic anticancer effects, to maximize the treatment effect, and to overcome multi-drug resistance. The purpose of this study is to construct lipid-polymer hybrid nanoparticles (LPNs) as nanomedicine for co-encapsulation of DTX and curcumin (CUR). Methods: DTX and CUR co-encapsulated LPNs (DTX-CUR-LPNs) were constructed. DTX-CUR-LPNs were evaluated in terms of particles size, zeta potential, drug encapsulation, and drug delivery. The cytotoxicity of the LPNs was evaluated on PC-3 human prostate carcinoma cells (PC3 cells) by MTT assays. In vivo anti-tumor effects were observed on the PC3 tumor xenografts in mice.Results: The particle size of DTX-CUR-LPNs was 169.6 nm with a positive zeta potential of 35.7 mV. DTX-CUR-LPNs showed highest cytotoxicity and synergistic effect of two drugs in tumor cells in vitro. In mice-bearing PC-3 tumor xenografts, the DTX-CUR-LPNs inhibited tumor growth to a greater extent than other contrast groups, without inducing any obvious side effects. Conclusion: According to these results, the novel nanomedicine offers great promise for the dual drugs delivery to the prostate cancer cells, showing the potential of synergistic combination therapy for prostate cancer.

PEG‐PLA nanoparticles decorated with small‐molecule PSMA ligand for targeted delivery of galbanic acid and docetaxel to prostate cancer cells

“…In a study by Yan et al, docetaxel and curcumin encapsulated into lipid-polymer hybrid nanoparticles (LPNs) showed higher cytotoxicity in PC-3 human prostate carcinoma cells compared with single drug-encapsulated LPNs and free drug solutions. The same results was also obtained in in vivo experiment on human PCa-bearing Balb/ c nude mice (Yan et al, 2016).…”

Styrene maleic acid-encapsulated RL71 micelles suppress tumor growth in a murine xenograft model of triple negative breast cancer

“…For example, highly potent tumor suppression was reported when doxorubicin (10 mg) and curcumin (100 mg) were combined in transferrin-targeted nanoparticles, 49 as well as following the co-encapsulation of docetaxel (5 mg/kg) and curcumin (10 mg/kg) in lipidpolymer hybrid nanoparticles. 50 Alternatively, the micelles could undergo further modifications to their exterior including the addition of folate 51 or other active targeting moieties. Therefore, there is potential to improve on the efficacy elicited by SMA-RL71.…”

Enhanced anticancer activity in vitro and in vivo of luteolin incorporated into long-circulating micelles based on DSPE-PEG2000 and TPGS

“…Micelles that incorporate PEG segment have been employed as long‐circulating drug vehicles . Following the intravenous injection, the nanoscale drug‐loaded micelles have been found to preferentially accumulate in the tumour tissues from their leaky endothelial vasculature, due to the enhanced permeability and retention effect .…”