Targeted nanotherapy platform mediated tumor-infiltrating CD8<sup>+</sup> T cell immune function effects for collaborative anti-tumor photothermal immunotherapy for cervical cancer

Wang, Lei; Chen, Jianhuan; Ma, Cailing; Zhang, Chuanshan

doi:10.1039/d3na01132a

Nanoscale Adv.

2024

DOI: 10.1039/d3na01132a

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Targeted nanotherapy platform mediated tumor-infiltrating CD8⁺ T cell immune function effects for collaborative anti-tumor photothermal immunotherapy for cervical cancer

Lei Wang,

Jianhuan Chen,

Cailing Ma

et al.

Abstract: Photothermal immunotherapy is an innovative approach to cancer treatment. It combines immunomodulators and photothermal agents, both targeted to the tumor site. This therapy harnesses the heat generated by photothermal conversion...

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2024

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Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Gu,

Wang

2024

Biomedicine & Pharmacotherapy

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Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Gu,

Wang

2024

Biomedicine & Pharmacotherapy

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Effect of Transferrin‐Modified Fe₃O₄ Nanoparticle Targeted Delivery miR‐15a‐5p Combined With Photothermal Therapy on Lung Cancer

Lan,

Wang,

Shao

et al. 2024

Thoracic Cancer

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BackgroundExisting studies have shown that transferrin receptor (TfR) is highly expressed on the surface of lung cancer cells, and nanoparticles (NPs) have been widely used as delivery vehicles. The aim of this study was to investigate the effect of the targeted delivery of Fe3O4 NPs modified with transferrin (Tf) compared with photothermal treatment for lung cancer.MethodsThe morphology and properties of Fe3O4 NPs modified with Tf were tested by internal morphological characterization experiments including transmission electron microscopy, particle size meter infrared spectrometer and other experiments. The delivery of materials was investigated by cell proliferation and apoptosis experiments, and western blot experiment was used to detect yes‐associated protein 1(YAP1) protein expression changes after delivering miR‐15a‐5p. In addition, animal models were constructed to further explore the targeting properties of the material.ResultsThe results demonstrated that the nanomaterial has good stability and targeting properties. Meanwhile, we also discovered that the miR‐15a‐5p carried by NPs can inhibit cell growth after its entry to the lung cancer cells. The effect became more evident when the nanomaterials were assisted with laser therapy, as verified by in vivo and in vitro experiments. In terms of the related mechanism, miR‐15a‐5p inhibited YAP1 expression, which affected cell proliferation and apoptosis.ConclusionIn this study, Fe3O4 NPs modified with Tf delivered miR‐15a‐5p in combination with photothermal therapy for lung cancer. In future research, the targeted delivery of Tf and the photothermal synergy of nanomaterials will provide a theoretical basis for cancer treatment.

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Targeted nanotherapy platform mediated tumor-infiltrating CD8⁺ T cell immune function effects for collaborative anti-tumor photothermal immunotherapy for cervical cancer

Abstract: Photothermal immunotherapy is an innovative approach to cancer treatment. It combines immunomodulators and photothermal agents, both targeted to the tumor site. This therapy harnesses the heat generated by photothermal conversion...

Cited by 2 publications

References 35 publications

Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Effect of Transferrin‐Modified Fe₃O₄ Nanoparticle Targeted Delivery miR‐15a‐5p Combined With Photothermal Therapy on Lung Cancer

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Targeted nanotherapy platform mediated tumor-infiltrating CD8+ T cell immune function effects for collaborative anti-tumor photothermal immunotherapy for cervical cancer

Abstract: Photothermal immunotherapy is an innovative approach to cancer treatment. It combines immunomodulators and photothermal agents, both targeted to the tumor site. This therapy harnesses the heat generated by photothermal conversion...

Cited by 2 publications

References 35 publications

Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Advancements in nano-immunotherapy for gynecological cancers: A new frontier

Effect of Transferrin‐Modified Fe3O4 Nanoparticle Targeted Delivery miR‐15a‐5p Combined With Photothermal Therapy on Lung Cancer

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Product

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Targeted nanotherapy platform mediated tumor-infiltrating CD8⁺ T cell immune function effects for collaborative anti-tumor photothermal immunotherapy for cervical cancer

Effect of Transferrin‐Modified Fe₃O₄ Nanoparticle Targeted Delivery miR‐15a‐5p Combined With Photothermal Therapy on Lung Cancer