Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states: a clue for cancer inhibition through dual pathways

Zhang, Peng; Zhai, Jiao; Gao, Xueyun; Zhao, He; Su, Wenyong; Zhao, Lina

doi:10.1016/j.scib.2018.02.007

Cited by 14 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the inactive state of EGFR at the membrane of tumor cells could be maintained by binding Au 10 Peptide 5 -GE11 to avoid the dimerization and further inhibit the activities of tumor cells. Therefore, employing Au 10 Peptide 5 as EGFR TKIs delivery results in inhibiting cancer cells through dual pathways ( Zhang et al, 2018a ).…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

Sun

Wang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Epidermal growth factor receptor (EGFR) is an anticancer drug target for a number of cancers, such as non-small cell lung cancer. However, unsatisfying treatment effects, terrible side-effects, and development of drug resistance are current insurmountable challenges of EGFR targeting treatments for cancers. With the advancement of nanotechnology, an increasing number of inorganic nanomaterials are applied in EGFR-mediated therapy to improve those limitations and further potentiate the efficacy of molecular targeted cancer therapy. Given their facile preparation, easy modification, and biosecurity, inorganic nanoparticles (iNPs) have been extensively explored in cancer treatments to date. This review presents an overview of the application of some typical metal nanoparticles and nonmetallic nanoparticles in EGFR-targeted therapy, then discusses and summarizes the relevant advantages. Moreover, we also highlight future perspectives regarding their remaining issues. We hope these discussions inspire future research on EGFR-targeted iNPs.

show abstract

Section: Metallic Nanoparticlesmentioning

confidence: 99%

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

Sun

Wang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…5−7 Because of the good biocompatibility and low toxicity, the AuNPs have been potentially utilized in the treatment of tumors. 8 The study showed that the radiation doses of tumor tissue added to Au can be increased to 200% or higher relative to that of normal tissues without Au. 9,10 The AuNPs interact with radiation directly after receiving incident radiation (such as gamma rays, X-rays), become a new source of radiation, and emit high energy to cause damage to surrounding tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the gold nanoparticles (AuNPs) have aroused great interests in the applications of the detection of biomolecules, , design of nano bioprobes, , and nanomedicine. − Because of the good biocompatibility and low toxicity, the AuNPs have been potentially utilized in the treatment of tumors . The study showed that the radiation doses of tumor tissue added to Au can be increased to 200% or higher relative to that of normal tissues without Au. , The AuNPs interact with radiation directly after receiving incident radiation (such as gamma rays, X-rays), become a new source of radiation, and emit high energy to cause damage to surrounding tumor tissue. , However, the core size of AuNPs and protective ligands on the surface affect its distribution in the organism, which may be absorbed by the reticuloendothelial system (RES) resulting in low tumor absorption and inevitable accumulation in the liver, , leading to potential toxicity .…”

Section: Introductionmentioning

confidence: 99%

Glutathione-Coated Au₂₉(SG)₂₇: Structural Determination Based on Different Combination Styles Confirmed by Experiments

Wang

Gao

et al. 2019

J. Phys. Chem. C

Self Cite

View full text Add to dashboard Cite

Glutathione-coated small-sized gold nanocluster denoted as Au 29 (SG) 27 has potential applications in bio therapeutics. Because it is difficult to obtain an accurate atomic structure experimentally, its structure is predicted by the density functional theory. The atomic structure of Au 29 (SG) 27 is speculated to contain a ring motif (for low Au/S ratio), Au 4 core, and staple motifs (by "divide and protect" method). In the structural optimization, we proposed the four various combination styles and took the second and third combinations, respectively, when N ≤ 6 and N > 6 (N is the number of Au atoms in the ring motif). All stable isomers are sorted by energy, and the structure with the lowest energy (isomer 1) consists of a Au 7 (SCH 3 ) 7 ring motif and Au 4 coreattached staple motifs as Au 4 Au 8 (SCH 3 ) 9 Au 10 (SCH 3 ) 11 . Then, we calculated and analyzed the atomic and electronic structures of isomer 1. The electronic transition of highest occupied molecular orbital (HOMO)−lowest unoccupied molecular orbital (LUMO) is mainly the transition from the d orbital to p orbital, which is within the gold core or between the gold core and ring motif. The ultraviolet−visible absorption spectrum calculated by time-dependent density functional is in good agreement with the experimental measurement to confirm the atomic structure of Au 29 (SG) 27 predicted by the combination-style strategy.

show abstract

“…[14][15][16][17] As a matter of fact, besides the distinct role as a host to carry guest molecules, proteins are also excellent biomineralisation templates for guiding the nucleation and growth of inorganic materials, such as fluorescent semiconductor quantum dots and metal nanoclusters. [18][19][20] Importantly, proteins possess welldefined structures and multiple binding sites that can impose exquisite control on the size, chemistry and localisation of the inorganic fluorescent product. Thus, these proteins hold great potential as biotemplates for generating fluorophores directly within the photoswitch systems, which will largely simplify the fabrication process of fluorescent photoswitches and enable a better control of their physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Site‐specific fabrication of gold nanocluster‐based fluorescence photoswitch enabled by the dual roles of albumin proteins

Zhong

Yan

et al. 2022

Aggregate

View full text Add to dashboard Cite

Fluorescence photoswitch is becoming increasingly desirable for many applications, but its controllable fabrication still remains challenging yet. In this paper, a new strategy is proposed to fabricate fluorescence photoswitch by harnessing dual roles of albumin proteins as both photochrome carriers and biotemplates of fluorophore. As an example, we demonstrated the successful fabrication of a fluorescence photoswitch by incorporating both the photochromic diarylethene dye (CMTE) and red‐emitting fluorescent gold nanoclusters (AuNCs) into the specific domains of bovine serum albumin (BSA) in a highly controllable manner. Detailed spectral and photophysical characterisation showed that CMTE well‐retains the photochromic properties within the CMTE–BSA–AuNC construct, although its photoconversion rate is slightly retarded. Different from previously reported photoswitches, the fluorescence of the present system is mainly modulated via the inner filter effect (IFE) mechanism, which exhibits high switching efficiency with an on–off ratio up to 90%, reversible fluorescence response and good antifatigue performance. This work provides a new, generable albumin protein‐assisted strategy of fabricating advanced fluorescence photoswitch, which can find wide applications in biological, optical and information fields.

show abstract

Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states: a clue for cancer inhibition through dual pathways

Cited by 14 publications

References 43 publications

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

Glutathione-Coated Au₂₉(SG)₂₇: Structural Determination Based on Different Combination Styles Confirmed by Experiments

Site‐specific fabrication of gold nanocluster‐based fluorescence photoswitch enabled by the dual roles of albumin proteins

Contact Info

Product

Resources

About

Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states: a clue for cancer inhibition through dual pathways

Cited by 14 publications

References 43 publications

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

Glutathione-Coated Au29(SG)27: Structural Determination Based on Different Combination Styles Confirmed by Experiments

Site‐specific fabrication of gold nanocluster‐based fluorescence photoswitch enabled by the dual roles of albumin proteins

Contact Info

Product

Resources

About

Glutathione-Coated Au₂₉(SG)₂₇: Structural Determination Based on Different Combination Styles Confirmed by Experiments