Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis

Danazumi, Ammar Usman; Ishmam, Ibtida Tabassum; Idris, Salisu; Izert, Matylda Anna; Balogun, E.O.; Górna, Maria W.

doi:10.1016/j.ejps.2023.106451

Cited by 4 publications

(3 citation statements)

References 188 publications

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“…Additionally, they can offer comprehensive protein information to explore the pathogenesis and progression of related diseases, uncover intricate cellular metabolic pathways and signalling networks and identify key factors and associated proteins involved in disease development. This enhances our understanding of diseases and facilitates further research, drug design and the development of treatment strategies (Refs 13 , 14 ). In accordance with the illustration provided in Figure 1 , some of the target protein identification techniques currently being developed include mass spectrometry (MS), polyacrylamide gel electrophoresis (PAGE) and immunological methods.…”

Section: Introductionmentioning

confidence: 93%

Trauma diagnostic-related target proteins and their detection techniques

Wei,

Ren,

Yuan

et al. 2024

Expert Rev. Mol. Med.

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Trauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among trauma patients. Target protein identification technology is a vital technique in the field of biomedical research, enabling the study of biomolecular interactions, drug discovery and disease treatment. It plays a crucial role in identifying key protein targets associated with specific diseases or biological processes, facilitating further research, drug design and the development of treatment strategies. The application of target protein technology in biomarker detection enables the timely identification of newly emerging infections and complications in trauma patients, facilitating expeditious medical interventions and leading to reduced post-trauma mortality rates and improved patient prognoses. This review provides an overview of the current applications of target protein identification technology in trauma-related complications and provides a brief overview of the current target protein identification technology, with the aim of reducing post-trauma mortality, improving diagnostic efficiency and prognostic outcomes for patients.

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Section: Introductionmentioning

confidence: 93%

Trauma diagnostic-related target proteins and their detection techniques

Wei,

Ren,

Yuan

et al. 2024

Expert Rev. Mol. Med.

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“…TPD technologies represent an emerging therapeutic class that removes disease-causing proteins involved in different disease types . These include PROTACs, molecular glues, LYTACs, autophagy targeting chimeras (AUTACs), and AbTACs, among others.…”

Section: Current State Of Psychedelic Researchmentioning

confidence: 99%

Unraveling Psychedelic Responses: Targeted Protein Degradation and Genetic Diversity

Kargbo

2023

ACS Med. Chem. Lett.

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This Viewpoint discusses the intersection of targeted protein degradation (TPD) technologies and psychedelic research. The resurgence in interest in psychedelics for treating mental disorders and the known genetic variability in responses require new strategies. TPD technologies might address this variability, modulating protein expressions based on genetic profiles. The discussion includes potential challenges in implementing TPD technologies in psychedelic research and potential strategies to address these issues. It considers lessons from COVID-19 research on genetic variability, proposing integration of TPD technologies into psychedelic research as a promising field despite these challenges, possibly leading to personalized treatments and improved patient outcomes.

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“…Currently, about 60 million people are at risk of this infection [ 6 ] whereas AAT hinders the production of livestock especially cattle which is a major setback to the economic development of most affected areas [ 7 ]. In the absence of vaccine due to antigenic variation displayed by the trypanosome parasites, chemotherapy remains the most viable and efficient option for treatment or control of African trypanosomiasis [ 8 ]. HAT is treated with Pentamidine, Suramin, Melarsoprol, Eflornithine, Nifurtimox and Fexinidazole depending on the stage of the disease [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

An In vitro and in silico investigation of the antitrypanosomal activities of the stem bark extracts of Anopyxis klaineana (Pierre) Engl

Adams,

Obiri-Yeboah,

Afiadenyo

et al. 2024

Heliyon

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Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis

Cited by 4 publications

References 188 publications

Trauma diagnostic-related target proteins and their detection techniques

Trauma diagnostic-related target proteins and their detection techniques

Unraveling Psychedelic Responses: Targeted Protein Degradation and Genetic Diversity

An In vitro and in silico investigation of the antitrypanosomal activities of the stem bark extracts of Anopyxis klaineana (Pierre) Engl

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