Targeted proteomic response to coffee consumption

Kuang, Alan; Erlund, Iris; Herder, Christian; Westerhuis, Johan A.; Tuomilehto, Jaakko; Cornelis, Marilyn C.

doi:10.1007/s00394-019-02009-1

Cited by 3 publications

(1 citation statement)

References 92 publications

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“…Alcohol consumption has previously been demonstrated to inhibit immune system activation by decreasing T-cell activity and IL-12 levels in healthy individuals [45]. In addition, high coffee consumption may also lead to decreased levels of IL-12, as has been reported previously [46]. Interestingly, coffee contains chlorogenic acid (CGA), a compound to which this IL-12-lowering effect has previously been attributed to, since this is consistent with data from experimental studies showing the inhibition of IL-12 secretion upon stimulation of adenosine 2A receptors (of which CGA is a common ligand) [47].…”

Section: Discussionsupporting

confidence: 60%

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Bourgonje

Bolte²,

Vranckx³

et al. 2022

Nutrients

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Diet plays an important role in the development and progression of inflammatory bowel disease (IBD, comprising Crohn’s disease (CD) and ulcerative colitis (UC)). However, little is known about the extent to which different diets reflect inflammation in IBD beyond measures such as faecal calprotectin or C-reactive protein. In this study, we aimed to unravel associations between dietary patterns and circulating inflammatory proteins in patients with IBD. Plasma concentrations of 73 different inflammation-related proteins were measured in 454 patients with IBD by proximity extension assay (PEA) technology. Food frequency questionnaires (FFQ) were used to assess habitual diet. Principal component analysis (PCA) was performed to extract data-driven dietary patterns. To identify associations between dietary patterns and plasma proteins, we used general linear models adjusting for age, sex, BMI, plasma storage time, smoking, surgical history and medication use. Stratified analyses were performed for IBD type, disease activity and protein intake. A high-sugar diet was strongly inversely associated with fibroblast growth factor-19 (FGF-19) independent of IBD type, disease activity, surgical history and deviance from recommended protein intake (false discovery rate (FDR) < 0.05). Conversely, a Mediterranean-style pattern was associated with higher FGF-19 levels (FDR < 0.05). A pattern characterised by high alcohol and coffee intake was positively associated with CCL11 (eotaxin-1) levels and with lower levels of IL-12B (FDR < 0.05). All results were replicated in CD, whereas only the association with FGF-19 was significant in UC. Our study suggests that dietary habits influence distinct circulating inflammatory proteins implicated in IBD and supports the pro- and anti-inflammatory role of diet. Longitudinal measurements of inflammatory markers, also postprandial, are needed to further elucidate the diet–inflammation relationship.

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Section: Discussionsupporting

confidence: 60%

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Bourgonje

Bolte²,

Vranckx³

et al. 2022

Nutrients

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The role of volatile and non-volatile compounds as quality indicators and marker candidates in coffee: A systematic review

Ayseli

2025

Journal of Food Composition and Analysis

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Coffee and Lower Risk of Type 2 Diabetes: Arguments for a Causal Relationship

2021

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Prospective epidemiological studies concur in an association between habitual coffee consumption and a lower risk of type 2 diabetes. Several aspects of these studies support a cause–effect relationship. There is a dependency on daily coffee dose. Study outcomes are similar in different regions of the world, show no differences between sexes, between obese versus lean, young versus old, smokers versus nonsmokers, regardless of the number of confounders adjusted for. Randomized controlled intervention trials did not find a consistent impact of drinking coffee on acute metabolic control, except for effects of caffeine. Therefore, lowering of diabetes risk by coffee consumption does not involve an acute effect on the post-meal course of blood glucose, insulin or insulin resistance. Several studies in animals and humans find that the ingestion of coffee phytochemicals induces an adaptive cellular response characterized by upregulation and de novo synthesis of enzymes involved in cell defense and repair. A key regulator is the nuclear factor erythroid 2-related factor 2 (Nrf2) in association with the aryl hydrocarbon receptor, AMP-activated kinase and sirtuins. One major site of coffee actions appears to be the liver, causing improved fat oxidation and lower risk of steatosis. Another major effect of coffee intake is preservation of functional beta cell mass via enhanced mitochondrial function, lower endoplasmic reticulum stress and prevention or clearance of aggregates of misfolded proinsulin or amylin. Long-term preservation of proper liver and beta cell function may account for the association of habitual coffee drinking with a lower risk of type 2 diabetes, rather than acute improvement of metabolic control.

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Targeted proteomic response to coffee consumption

Cited by 3 publications

References 92 publications

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

The role of volatile and non-volatile compounds as quality indicators and marker candidates in coffee: A systematic review

Coffee and Lower Risk of Type 2 Diabetes: Arguments for a Causal Relationship

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