Targeted screening and quantitative analyses of antioxidant compounds in aged-garlic extract

Matsutomo, Toshiaki; Stark, Timo D.; Hofmann, Thomas

doi:10.1007/s00217-018-3092-6

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…Most Allium species possess characteristic aromas and are edible. Garlic ( Allium sativum ) is consumed as a seasoning worldwide, and has been used for its important medicinal properties for centuries (Itakura et al, 2001; Martins, Petropoulos & Ferreira, 2016; Matsutomo, Stark & Hofmann, 2018; Mukthamba & Srinivasan, 2015). Many components in garlic, including sulphur-free compounds, work together to provide various health benefits.…”

Section: Introductionmentioning

confidence: 99%

Comparative study on the composition of four different varieties of garlic

Chen

Cai

Liu

et al. 2019

PeerJ

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Garlic is used as a medicinal seasoning worldwide. The aim of this work was to compare four varieties of garlic: ‘Taicangbaipi’, ‘Ershuizao’, ‘Hongqixing’, and ‘Single-clove’; among them, ‘Ershuizao’ and ‘Hongqixing’ are unique to the Sichuan Province of China. Firstly, soluble sugar, starch, and the protein content of the garlic were analysed. There was more soluble sugar in ‘Single-clove’, total starch in ‘Hongqixing’, and protein content in ‘Ershuizao’ relative to the other three varieties, respectively. Gas chromatography–mass spectrometry analysis showed that ‘Ershuizao’ and ‘Hongqixing’ contained high levels of 5-hydroxymethylfurfural, which has antitumor, antioxidant, and cytoprotective effects. Indeed, the extracts from these two types of garlic were more effective at inhibiting tumour growth than that from the others. Moreover, the sulphide content and antimicrobial effects of ‘Ershuizao’ and ‘Hongqixing’ garlic were also higher than those of the other two types of garlic. In addition, changes observed in the membrane permeability and protein leakage suggest that the antimicrobial activity of the ‘Ershuizao’ and ‘Hongqixing’ extracts may be due to the destruction of the structural integrity of the cell membranes, leading to cell death.

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Section: Introductionmentioning

confidence: 99%

Comparative study on the composition of four different varieties of garlic

Chen

Cai

Liu

et al. 2019

PeerJ

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“…It is worth noting that there is currently no established bioanalytical method for determining or analyzing the bioavailability of Sallyl cysteine in the brain or its homogenate in the literature. [26][27][28][29] Thus, there is a need to develop novel bioanalytical methods capable of quantifying S-allyl cysteine at nanogram levels.…”

Section: Introductionmentioning

confidence: 99%

Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment

Khan,

Ahmad,

Alkholifi

et al. 2024

RSC Adv.

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“…Researchers have previously reported various methods for analyzing garlic extract samples or methods based on simultaneous analysis with more compounds [22][23][24]. Previously, two plasma analysis methods were published for S-Allyl-L-Cysteine: one of them was developed via µg per mL (0.10 to 100), and the other had a drawback run time of up to 12 min [1,25].…”

Section: Introductionmentioning

confidence: 99%

A Novel UHPLC-MS/MS-Based Bioanalytical Method Developed for S-Allyl Cysteine in the Establishment of a Comparative Pharmacokinetic Study

et al. 2023

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A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate the comparative pharmacokinetic parameters. SC PLGA NPs (S-Allyl Cysteine Poly (D,L-lactide-co-glycolic acid) Nanoparticles) were developed by the emulsion solvent evaporation method. SC PLGA NPs showed their drug loading and encapsulation efficiency to be 5.13 ± 0.10% and 82.36 ± 4.01%, respectively. SC PLGA NPs showed a spherical morphology of an average size (134.8 ± 4.61 nm), PDI: 0.277 ± 0.004, and −25.3 ± 1.03 mV Zeta-Potential (ZP), and is suitable for oral delivery. The development and validation of the UHPLC-MS/MS bioanalytical method were performed successfully for PK-parameter examinations with 1.219 min RT, MS (162.00/73.10), and a total run-time of 2.0 min. Additionally, 1.0–1000.0 ng/mL was a linear range with inter- and intra-day accuracy of 92.55–99.40%, followed by a precision of 1.88–4.23%. SC PLGA NP’s oral bioavailability was significantly higher (** p < 0.01) in comparison to the SC-S treated groups’ (iv and oral). The antimicrobial activity of SC PLGA NPs proved to be more effective than pure S-Allyl-L-Cysteine with significant results (p < 0.01) in comparison to SC-S. SC PLGA NPs showed fitted physicochemical and enhanced antimicrobial properties, which can be helpful for oral administration. Based on the proposed research results, SC PLGA NPs were used for the improvement in oral bioavailability with a sustained and controlled release of S-Allyl-L-Cysteine delivery.

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Targeted screening and quantitative analyses of antioxidant compounds in aged-garlic extract

Cited by 12 publications

References 35 publications

Comparative study on the composition of four different varieties of garlic

Comparative study on the composition of four different varieties of garlic

Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment

A Novel UHPLC-MS/MS-Based Bioanalytical Method Developed for S-Allyl Cysteine in the Establishment of a Comparative Pharmacokinetic Study

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