Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer

Hou, Yan; Jin, Jingzhe; Duan, Hongxia; Liu, Chao; Chen, Liqing; Huang, Wei; Gao, Zhonggao; Jin, Mingji

doi:10.1016/j.biomaterials.2022.121440

Cited by 58 publications

(25 citation statements)

References 70 publications

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“…The CD receptor family comprises surface receptors mainly present on cancer stem cells (CSCs), including CD14, CD22, CD36, CD44, and CD133, which can be used as promising delivery targets against tumor metastasis. Among them, CD44, a transmembrane adhesion glycoprotein, has been commonly used to target receptors for targeted tumor treatment [ 90 – 92 ]. Hyaluronic acid (HA), a ligand with good biocompatibility, has been widely used in CD44 receptor-mediated active targeting delivery systems.…”

Section: Receptor-mediated Active Targeting Strategymentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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Section: Receptor-mediated Active Targeting Strategymentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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“…To date, multi-stimuli coatings for tablets, capsules and pellets have gained the most translational success within colonic drug delivery [50,51]. However, there is potential for multi-stimuli colon-targeted oral nanomedicines, though such systems are rare and yet to show significant results in human studies [154][155][156][157]. When designing new targeted formulations it is imperative to consider the safety of materials for oral delivery.…”

Section: Multi-stimuli Systems For Colonic Drug Delivery Via the Oral...mentioning

confidence: 99%

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

McCoubrey

Favaron

Awad

et al. 2023

Journal of Controlled Release

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“…Inulin could protect the drug from the acidic environment of the stomach and upper gastrointestinal tract. It is degraded by inulinase in the colon for the controlled release of the drug employed as a drug carrier to target the colon [ 190 ].…”

Section: Targeted Nps In Crc Researchmentioning

confidence: 99%

Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer

et al. 2022

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Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and some patients are advanced at the time of diagnosis and have no chance for complete surgical resection. These factors make chemotherapy an indispensable and important tool in treating CRC. However, the complex composition of the tumor microenvironment and the interaction of cellular and interstitial components constitute a tumor tissue with high cell density, dense extracellular matrix, and high osmotic pressure, inevitably preventing chemotherapeutic drugs from entering and acting on tumor cells. As a result, a novel drug carrier system with targeted nanoparticles has been applied to tumor therapy. It can change the physicochemical properties of drugs, facilitate the crossing of drug molecules through physiological and pathological tissue barriers, and increase the local concentration of nanomedicines at lesion sites. In addition to improving drug efficacy, targeted nanoparticles also reduce side effects, enabling safer and more effective disease diagnosis and treatment and improving bioavailability. In this review, we discuss the mechanisms by which infiltrating cells and other stromal components of the tumor microenvironment comprise barriers to chemotherapy in colorectal cancer. The research and application of targeted nanoparticles in CRC treatment are also classified.

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Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer

Cited by 58 publications

References 70 publications

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer

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