Targeted Therapies and Druggable Genetic Anomalies in Acute Myeloid Leukemia: From Diagnostic Tools to Therapeutic Interventions

Abstract

Acute myeloid leukemia (AML) is a clonal disorder resulting from acquired somatic mutations in hematopoietic progenitor cells that lead to the dysregulation of differentiation and the proliferation of hematopoietic cells [...]

Issue Highlights—July 2022

“…Interestingly, the immunophenotype of KMT2A-rearranged AML was found to be different from other AML Rondoni Michela [Color figure can be viewed at wileyonlinelibrary.com] subcategories. KMT2A-rearranged AML is an aggressive subtype of AML with frequent monocytic or myelomonocytic differentiation, and some cases can present with lineage switch to acute lymphoblastic leukemia (Collins et al, 2020;Lanza & Bazarbachi, 2021). Interestingly, some cases of KMT2A-rearranged AML have an APL-like immunophenotype.…”