2010
DOI: 10.1016/s1470-2045(09)70370-5
|View full text |Cite
|
Sign up to set email alerts
|

Targeted therapy for biliary-tract cancer

Abstract: Abstract:It is necessary to establish effective chemotherapy to improve the survival of patients with biliary tract cancer, because most of these patients are unsuitable candidates for surgery, and even patients undergoing curative surgery often have recurrence. Recently, the combination of cisplatin plus gemcitabine was reported to show survival benefits over gemcitabine alone in randomized clinical trials conducted in the United Kingdom and Japan. Thus, the combination of cisplatin plus gemcitabine is now re… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
3
0

Year Published

2012
2012
2021
2021

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 40 publications
0
3
0
Order By: Relevance
“…It is unclear whether combined treatment with molecular targeted agents or other cytotoxic chemotherapeutic agents may also be effective against BTC [26,27]. Although incorporation of targeted therapy with gemcitabine plus platinum may improve outcomes, erlotinib did not improve progression-free survival in a randomized phase 3 trial of patients with metastatic BTC [10].…”
Section: Discussionmentioning
confidence: 99%
“…It is unclear whether combined treatment with molecular targeted agents or other cytotoxic chemotherapeutic agents may also be effective against BTC [26,27]. Although incorporation of targeted therapy with gemcitabine plus platinum may improve outcomes, erlotinib did not improve progression-free survival in a randomized phase 3 trial of patients with metastatic BTC [10].…”
Section: Discussionmentioning
confidence: 99%
“…These targeted therapies offer hope of improved survival in patients with BTC 20‐24 . As monotherapy they have minor effect, but in combination with systemic chemotherapy, they have both shown to have synergistic effect 3,25 …”
Section: Introductionmentioning
confidence: 99%
“…[20][21][22][23][24] As monotherapy they have minor effect, but in combination with systemic chemotherapy, they have both shown to have synergistic effect. 3,25 Our aim was to investigate whether panitumumab or bevacizumab in combination with chemotherapy should proceed to further clinical development. We designed a randomized cross-over Phase II screening trial primarily to compare the rate of PFS at 6 months and secondarily to compare other endpoints as signals of clinical effect.…”
mentioning
confidence: 99%