Targeted therapy for cancer using pH-responsive nanocarrier systems

Manchun, Somkamol; Dass, Crispin R.; Sriamornsak, Pornsak

doi:10.1016/j.lfs.2012.01.008

Cited by 177 publications

(117 citation statements)

References 57 publications

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“…13 Measured tumour extracellular pH values of many solid tumours range from pH 6.5 to pH 7.2, and the pH within cancerous cells may be between pH 5.0 and pH 6.0 in endosomes, and between pH 4.0 and pH 5.0 in lysosomes. 14 The synthesis of pendant-functionalised polyesters may be achieved by utilising O-carboxyanhydride (OCA) ROP.…”

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confidence: 99%

Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

et al. 2017

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confidence: 99%

Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

et al. 2017

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“…Passive targeting refers to the extravagation of nanocarriers through leaky tumor capillary fenestrations that results from abnormalities of angiogenesis at the tumor site, resulting in accumulation and retention. This phenomenon was recognized as the EPR effect [3].…”

Section: Passive Targetingmentioning

confidence: 99%

“…The common cancer treatments are chemotherapy, radiation, and surgery with chemotherapy being the major treatment modality [3]. Use of chemotherapy has proven beneficial in improving survival rate for cancer to some extent [4].…”

Section: Introductionmentioning

confidence: 99%

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

et al. 2014

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Cancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand-receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.

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“…For example, Engleman has developed a low pH inserting peptide, pHLIP, that has been used to develop molecular imaging agents as well as a targeting moiety to distribute chemotherapeutics to low pH regions [39][40][41]. Additionally, whole families of pH-sensitive nanoparticles, nanogels, liposomes and micelles have been developed to release their chemotherapeutic payloads only under acidic conditions [42][43][44][45][46][47][48]. This is a very dynamic area of research, which has shown dramatic anti-tumour effects.…”

Section: (A) Exploiting Tumour Aciditymentioning

confidence: 99%

Targeting ion transport in cancer

Oosterwijk

Gillies

2014

Phil. Trans. R. Soc. B

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The metabolism of cancer cells differs substantially from normal cells, including ion transport. Although this phenomenon has been long recognized, ion transporters have not been viewed as suitable therapeutic targets. However, the acidic pH values present in tumours which are well outside of normal limits are now becoming recognized as an important therapeutic target. Carbonic anhydrase IX (CAIX) is fundamental to tumour pH regulation. CAIX is commonly expressed in cancer, but lowly expressed in normal tissues and that presents an attractive target. Here, we discuss the possibilities of exploiting the acidic, hypoxic tumour environment as possible target for therapy. Additionally, clinical experience with CAIX targeting in cancer patients is discussed.

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Targeted therapy for cancer using pH-responsive nanocarrier systems

Cited by 177 publications

References 57 publications

Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

Targeting ion transport in cancer

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