Targeted therapy of oral hairy leukoplakia with gentian violet

Bhandarkar, Sulochana S.; MacKelfresh, Jamie; Fried, Levi; Arbiser, Jack L.

doi:10.1016/j.jaad.2007.11.017

Cited by 36 publications

(25 citation statements)

References 9 publications

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“…At present, there is no universal therapy for the management of OHL; however, high dose oral valacyclovir may be used safely and effectively [148]. Alternatively, topical treatment, that is, 25% podophyllin resin alone or in combination with 5% topical acyclovir, and gentian violet could be considered [149–151]. …”

Section: Present Practice and Therapeutic Optionsmentioning

confidence: 99%

Oral Complications and Management Strategies for Patients Undergoing Cancer Therapy

Wong

2014

The Scientific World Journal

103

102

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With cancer survival rate climbing up over the past three decades, quality of life for cancer patients has become an issue of major concern. Oral health plays an important part in one's overall quality of life. However, oral health status can be severely hampered by side effects of cancer therapies including surgery, chemotherapy, radiotherapy, and hematopoietic stem cell transplantation. Moreover, prevention and treatment of these complications are often overlooked in clinical practice. The present paper aims at drawing health care professionals' attention to oral complications associated with cancer therapy by giving a comprehensive review. Brief comments on contemporary cancer therapies will be given first, followed by detailed description of oral complications associated with cancer therapy. Finally, a summary of preventive strategies and treatment options for common oral complications including oral mucositis, oral infections, xerostomia, and dysgeusia will be given.

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Section: Present Practice and Therapeutic Optionsmentioning

confidence: 99%

Oral Complications and Management Strategies for Patients Undergoing Cancer Therapy

Wong

2014

The Scientific World Journal

103

102

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“…Recently, we have found that triphenylmethane dyes, such as gentian violet, block the activity of nox2 and nox4 and eliminate the growth of experimental hemangiomas in mice (39). Gentian violet has been shown to be clinically effective against oral hairy leukoplakia, a condition caused by epithelial infection with Epstein Barr virus (EBV) which causes reactive oxygen generation (40,41). Currently, novel derivatives of gentian violet are being synthesized for systemic use against solid and hematopoietic tumors that use reactive oxygen for signaling.…”

Section: Targeting Reactive Oxygen To Treat Skin Diseasesmentioning

confidence: 99%

Application of Angiogenesis to Clinical Dermatology

Fried

Arbiser

2008

Advances in Dermatology

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“…However, in case of using a biopsy specimen, as in the present case, PCR analysis is as specific and sensitive for the detection of EBV as in situ hybridization 3 . Successive treatment modalities using a range of topical agents, such as tretinoin solution, podophylline resin, gentian violet or antiviral agent, have been reported 4,16,[19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Oral Hairy Leukoplakia Which Occurred as a Presenting Sign of Acute Myeloid Leukemia in a Child

et al. 2010

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Oral hairy leukoplakia (OHL) is caused by the reactivation of a previous Epstein-Barr virus (EBV) infection in the epithelium of the tongue. Most lesions are characterized by corrugated whitish patches on the lateral border of the tongue. It is frequently associated with AIDS, but cases in patients with other immunosuppressed states have also been reported. In leukemia patients, OHL is rarely encountered, and appears only after chemotherapy. We report a case of OHL which occurred as a presenting sign of acute myeloid leukemia (AML) in a previously healthy 15-year-old child. A 15-year-old boy presented with a whitish patch on the left lateral border of the tongue. The biopsy specimen revealed papillomatosis, hyperkeratosis, acanthosis and ballooning degeneration in the stratum spinosum. The patient was EBV seropositive, and PCR analysis of EBV DNA in the lesional tissue was positive. After the diagnosis of OHL in dermatologic department, the patient was referred to pediatrics due to the abnormal peripheral blood smear, and was diagnosed with AML. (Ann Dermatol 22(1) 73∼76, 2010)

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Targeted therapy of oral hairy leukoplakia with gentian violet

Cited by 36 publications

References 9 publications

Oral Complications and Management Strategies for Patients Undergoing Cancer Therapy

Oral Complications and Management Strategies for Patients Undergoing Cancer Therapy

Application of Angiogenesis to Clinical Dermatology

Oral Hairy Leukoplakia Which Occurred as a Presenting Sign of Acute Myeloid Leukemia in a Child

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