Targeted treatment of triple-negative-breast cancer through pH-triggered tumour associated macrophages using smart theranostic nanoformulations

Scialla, Stefania; Hanafy, Mahmoud S.; Wang, Jieliang; Genicio, Nuria; Silva, Milene; Costa, Marta; Oliveira-Pinto, Sofia; Baltazar, Fátima; Gallo, Juan; Cui, Zhengrong; Bañobre‐López, Manuel

doi:10.1016/j.ijpharm.2022.122575

Cited by 11 publications

(8 citation statements)

References 72 publications

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“…Breast cancer is one of the most common solid-tissue cancers and the leading cause of cancer death in women worldwide [1,2]. There are several types of breast cancer; however, the most aggressive form, known as triplenegative breast cancer (TNBC), accounts for 15-25% of diagnoses in women [1].…”

Section: Overview Of Breast Cancermentioning

confidence: 99%

Targeting Macrophages as a Novel Therapy to Treat Triple-Negative Breast Cancer: A Literature Review

Todrick,

Ma,

Singh

2024

URNCST Journal

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Triple-negative breast cancer (TNBC) is a highly aggressive form of cancer which lacks the traditional cellular targets of other types of breast cancer. As such, it is increasingly important to find alternative targets to treat this deadly disease. Recently, tumour-associated macrophages (TAMs) have become an exciting area of focus for cancer research and may provide a source of treatment options for TNBC. Macrophages are an important part of the innate immune response and also play a crucial role in tumour progression, inflammation, and metastasis. TAMs fall along a spectrum and are generally presented as either M1 type or M2 type. M1 macrophages are considered anti-tumorigenic whereas M2 macrophages are considered pro-tumorigenic, promoting tumour growth and inhibiting T-cell response. A search of the University of Alberta's online library database was carried out with a specific emphasis on clinical research. Search efforts focused on the effects of macrophages on the progression of breast cancer. Further searches were performed to determine the efficacy of targeting macrophages to treat cancer. Increasing the relative ratio of M1 to M2 macrophages or depletion of macrophages may lead to a better prognosis in TNBC. TAMs may be repolarized to M1 phenotype using metformin, inhibition of SerpinE2, YAP/STAT3, or MED1/PPAR𝛾. Macrophage recruitment to the tumour microenvironment may be inhibited by targeting chemokines such as CCL2. Current methods could not efficiently deplete macrophages at such a high abundance. The abundance of macrophages and their phagocytic properties could instead be exploited to increase tumour cell phagocytosis by targeting the CD47-SIRPɑ axis. Exciting opportunities have been revealed regarding inhibition of macrophage recruitment, repolarization of M2 to M1 type, and through exploitation of phagocytic properties of macrophages. However, conflicting results can be found for all these emerging treatment strategies. Worsening matters is the lack of knowledge regarding macrophage functions and the confusing landscape of macrophages current naming conventions. As such, further research is required to determine the efficacy of macrophages as a target in breast cancer treatment.

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Section: Overview Of Breast Cancermentioning

confidence: 99%

Targeting Macrophages as a Novel Therapy to Treat Triple-Negative Breast Cancer: A Literature Review

Todrick,

Ma,

Singh

2024

URNCST Journal

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Section: Novel Nano-drug Delivery Systemsmentioning

confidence: 99%

“…The reason for this was that iron-containing nanoparticles enhance intracellular ROS production and thus DOX-induced apoptosis in triple positive breast cancer cells. Scialla et al ( Scialla et al, 2023 ) successfully synthesized magnetic nanoparticles (AS-mLNVs-DOX) with great stability and biocompatibility by one-pot method ( Figure 2C ). The nanoparticles constructed were modified by a combination of two molecules with complementary functions: 1) mannose ligand (macrophage-targeting); 2) Geranylgeranylic acid sensitivity detachable polyethylene glycol (PEG) molecules (specificity), which endowed the system with excellent pH responsiveness and targeting properties.…”

Section: Novel Nano-drug Delivery Systemsmentioning

confidence: 99%

Advances in Doxorubicin-based nano-drug delivery system in triple negative breast cancer

Zeng,

Luo,

Gan

et al. 2023

Front. Bioeng. Biotechnol.

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Triple positive breast cancer (TPBC) is one of the most aggressive breast cancer. Due to the unique cell phenotype, aggressiveness, metastatic potential and lack of receptors or targets, chemotherapy is the choice of treatment for TNBC. Doxorubicin (DOX), one of the representative agents of anthracycline chemotherapy, has better efficacy in patients with metastatic TNBC (mTNBC). DOX in anthracycline-based chemotherapy regimens have higher response rates. Nano-drug delivery systems possess unique targeting and ability of co-load, deliver and release chemotherapeutic drugs, active gene fragments and immune enhancing factors to effectively inhibit or kill tumor cells. Therefore, advances in nano-drug delivery systems for DOX therapy have attracted a considerable amount of attention from researchers. In this article, we have reviewed the progress of nano-drug delivery systems (e.g., Nanoparticles, Liposomes, Micelles, Nanogels, Dendrimers, Exosomes, etc.) applied to DOX in the treatment of TNBC. We also summarize the current progress of clinical trials of DOX combined with immune checkpoint inhibitors (ICIS) for the treatment of TNBC. The merits, demerits and future development of nanomedicine delivery systems in the treatment of TNBC are also envisioned, with the aim of providing a new class of safe and efficient thoughts for the treatment of TNBC.

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“…Recent developments in the biomedical field have brought us to advanced technologies of the medical world such as targeted drug delivery systems (DDSs), rapid wound healing, antibacterial wound dressing, bone regeneration, and dentistry . However, the existing technology and biomedical treatment still needs to be controlled carefully by humans due to its nonresponsive properties with respect to the working environment that leads to ineffective treatment, risking a patient’s health and decreasing the biomaterial lifespan. − Therefore, the research on smart biomaterials has gained interest over the past decades to meet the demands of various stimuli-responsive biomaterials for broad applications. − For example, Scialla et al successfully synthesized doxorubicin-loaded magnetic lipid-based nanovehicles exhibiting pH induced tumor associated macrophages (TAMs) for fighting triple-negative breast cancer (TNC) . Wibowo et al conducted an initial study on electroactive scaffolds for bone tissue engineering using polyaniline filled-polycaprolactone that exhibited comparable cell proliferation to pristine polycaprolactone with significantly higher conductivity and cytocompatibility .…”

Section: Introductionmentioning

confidence: 99%

“…10−13 For example, Scialla et al successfully synthesized doxorubicinloaded magnetic lipid-based nanovehicles exhibiting pH induced tumor associated macrophages (TAMs) for fighting triple-negative breast cancer (TNC). 14 Wibowo et al conducted an initial study on electroactive scaffolds for bone tissue engineering using polyaniline filled-polycaprolactone that exhibited comparable cell proliferation to pristine polycaprolactone with significantly higher conductivity and cytocompatibility. 15 Despite many materials that are suitable for the development of smart biomaterials, most of them remain insufficient for certain applications due to the uncontrolled degradation, risk of infection, insufficient mechanical properties, difficulties in bioaccumulation of degradation products, and local acidic environments.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past decade, smart and functional biomaterials have escalated as one of the most rapidly emerging fields in the life sciences because the performance of biomaterials could be improved by careful consideration of their interaction and response with the living systems. Thus, chitosan could play a crucial role in this frontier field because it possesses many beneficial properties, especially in the biomedical field such as excellent biodegradability, hemostatic properties, antibacterial activity, antioxidant properties, biocompatibility, and low toxicity. Furthermore, chitosan is a smart and versatile biopolymer due to its polycationic nature with reactive functional groups that allow the polymer to form many interesting structures or to be modified in various ways to suit the targeted applications. In this review, we provide an up-to-date development of the versatile structures of chitosan-based smart biomaterials such as nanoparticles, hydrogels, nanofibers, and films, as well as their application in the biomedical field. This review also highlights several strategies to enhance biomaterial performance for fast growing fields in biomedical applications such as drug delivery systems, bone scaffolds, wound healing, and dentistry.

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Targeted treatment of triple-negative-breast cancer through pH-triggered tumour associated macrophages using smart theranostic nanoformulations

Cited by 11 publications

References 72 publications

Targeting Macrophages as a Novel Therapy to Treat Triple-Negative Breast Cancer: A Literature Review

Targeting Macrophages as a Novel Therapy to Treat Triple-Negative Breast Cancer: A Literature Review

Advances in Doxorubicin-based nano-drug delivery system in triple negative breast cancer

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

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