Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum

Krais, Annette M.; Wortmann, Laura; Hermanns, Laura; Feliu, Neus; Vahter, Marie; Stucky, Stefan; Mathur, Sanjay; Fadeel, Bengt

doi:10.1016/j.nano.2014.01.006

Cited by 82 publications

(54 citation statements)

References 203 publications

(237 reference statements)

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“…Thus, although nanoparticles continued to enter the cells, the targeting specificity of transferrin was lost. In contrast, we previously observed that specific, i.e., FA-dependent uptake of FA-conjugated iron oxide nanoparticles by human ovarian cancer cells expressing the corresponding receptor was observed only in the presence of serum proteins, possibly due to a stabilizing effect of the serum proteins on the functionalized nanoparticles in vitro [103]. However, while Fe 3 O 4 -SiO 2 -FA particles were specifically internalized, Fe 3 O 4 -PEG-FA nanoparticles did not undergo specific (targeted) uptake in the same model cell line; it is conceivable that the targeting ligand (FA) on the PEGylated particles was embedded in a matrix of polymers and therefore not accessible for binding to its receptor [103].…”

Section: Bio-corona Formation On Carbon-based Nanomaterialsmentioning

confidence: 94%

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Bhattacharya

Mukherjee

Gallud

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

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357

226

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Carbon-based nanomaterials including single- and multi-walled carbon nanotubes, graphene oxide, fullerenes and nanodiamonds are potential candidates for various applications in medicine such as drug delivery and imaging. However, the successful translation of nanomaterials for biomedical applications is predicated on a detailed understanding of the biological interactions of these materials. Indeed, the potential impact of the so-called bio-corona of proteins, lipids, and other biomolecules on the fate of nanomaterials in the body should not be ignored. Enzymatic degradation of carbon-based nanomaterials by immune-competent cells serves as a special case of bio-corona interactions with important implications for the medical use of such nanomaterials. In the present review, we highlight emerging biomedical applications of carbon-based nanomaterials. We discuss recent studies on nanomaterial ‘coronation’ and how this impacts on biodistribution and targeting along with studies on the enzymatic degradation of carbon-based nanomaterials, and the role of surface modification of nanomaterials for these biological interactions.

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Section: Bio-corona Formation On Carbon-based Nanomaterialsmentioning

confidence: 94%

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Bhattacharya

Mukherjee

Gallud

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

Self Cite

357

226

View full text Add to dashboard Cite

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“…13,14 IONPs have been targeted to ovarian cancers via functionalization with folic acid, the natural ligand of FOLRα. 15 Importantly, however, folate is an essential nutrient, and healthy cells acquire folate from their environment via numerous high-affinity membrane receptor proteins and transporters, including FOLRα, FOLR beta, FOLR gamma, 19 reduced folate carrier (solute carrier …”

Section: Discussionmentioning

confidence: 99%

Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo

Ndong¹,

Toraya-Brown²,

Kekalo³

et al. 2015

IJN

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Active molecular targeting has become an important aspect of nanoparticle development for oncology indications. Here, we describe molecular targeting of iron oxide nanoparticles (IONPs) to the folate receptor alpha (FOLRα) using an engineered antibody fragment (Ffab). Compared to control nanoparticles targeting the non-relevant botulinum toxin, the Ffab-IONP constructs selectively accumulated on FOLRα-overexpressing cancer cells in vitro, where they exhibited the capacity to internalize into intracellular vesicles. Similarly, Ffab-IONPs homed to FOLRα-positive tumors upon intraperitoneal administration in an orthotopic murine xenograft model of ovarian cancer, whereas negative control particles showed no detectable tumor accumulation. Interestingly, Ffab-IONPs built with custom 120 nm nanoparticles exhibited lower in vitro targeting efficiency when compared to those built with commercially sourced 180 nm nanoparticles. In vivo, however, the two Ffab-IONP platforms achieved equivalent tumor homing, although the smaller 120 nm IONPs were more prone to liver sequestration. Overall, the results show that Ffab-mediated targeting of IONPs yields specific, high-level accumulation within cancer cells, and this fact suggests that Ffab-IONPs could have future utility in ovarian cancer diagnostics and therapy.

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“…Zhou et al [47] reported that Mac-1 receptors have also been involved in the extracellular dsRNA recognition. Folic acid functionalization of iron oxide nanoparticles with an organic and inorganic layers leads to the uptake by primary human macrophages (M-CSF differentiated) through endocytosis and folate receptor-a independently [48]. The charge of the nanoparticle will also define the nature of the protein adsorbed to their surface in a biological medium leading their interactions with cells.…”

Section: Nanomaterials Recognition By Macrophagesmentioning

confidence: 99%

Human macrophage responses to metal-oxide nanoparticles: a review

Borgognoni

Kim

Zucolotto

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Nanomaterials have been widely used in our daily lives in medicine, cosmetics, paints, textiles and food products. Many studies aim to determine their biological effects in different types of cells. The interaction of these materials with the immune system leads to reactions by modifying the susceptibility or resistance of the host body which could induce adverse health effects. Macrophages, as specific cells of the innate immune response, play a crucial role in the human defence system to foreign agents. They can be used as a reliable test object for the investigation of immune responses under nanomaterials exposure displayed by expression of a variety of receptors and active secretion of key signalling substances for these processes. This report covers studies of human macrophage behaviours upon exposure of nanomaterials. We focused on their interaction with metal-oxide nanoparticles as these are largely used in medical and cosmetics applications. The discussion and summary of these studies can guide the development of new nanomaterials, which are, at the same time, safe and useful for new purposes, especially for health applications.ARTICLE HISTORY

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Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum

Cited by 82 publications

References 203 publications

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo

Human macrophage responses to metal-oxide nanoparticles: a review

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