Targeted Wolfram-Doped Polypyrrole for Photonic Hyperthermia-Synergized Radiotherapy

Abstract

Single ionizing radiation at a tolerable dose is ineffectual in eliminating malignancies but readily generates harmful effects on surrounding normal tissues. Herein, we intelligently fabricated novel wolfram-doped polypyrrole (WPPy) through a simple oxidative polymerization method with WCl 6 as an oxidizing catalyst, which possessed good biocompatibility, high photothermal conversion, and intensive radiosensitivity capacities to concurrently serve as a photothermal reagent and a radiosensitizer for hyperthermia-synergized radiotherapy (RT) against a malignant tumor. In comparison with traditional polypyrrole without noble metal doping, the innovative introduction of WCl 6 not only successfully launched the polymerization of a pyrrole monomer but also endowed WPPy with additional radiosensitization. More importantly, after further decoration with an active targeted component (SP94 polypeptide), the obtained WPPy@SP94 significantly increased tumor internalization and accumulation in vitro and in vivo and induced obvious DNA damage as well as robust ROS generation under X-ray irradiation, which meanwhile synergized with strong photonic hyperthermia to effectively inhibit tumor growth by single drug injection. Moreover, such biocompatible WPPy@SP94 showed negligible adverse effects on normal cells and tissues. WPPy@SP94 developed in this study not only expands the category of polypyrrole chemical syntheses but also sheds light on WPPy@SP94-based radiosensitizers for cancer RT.

Ammonium Folate‐Reinforced Self‐Assembly of Gelatin into N/B/O‐Enriched Hierarchical Porous Carbons with Loosely Layered Structure for Anti‐Freezing Flexible Supercapacitors

“…Benefiting from its large specific capacitance, the maximum energy density ( E max ) of BNLC‐850 SC is 14.72 Wh Kg −1 , which is higher than the E max of heteroatom‐doped porous carbon‐based symmetric supercapacitors reported in recent literature (Figure 5e). [ 30–35 ] Moreover, BNLC‐850 SC also displayed long‐cycle performance, after 10000 cycles at 10 A g −1 , the capacitance retention rate is still as high as 92.1%. (Figure 5f).…”

Gas Phase‐Heat Absorption‐Condensate Phase Stepwise Flame Retardant Strategy to Prepare Coal Tar Pitch‐Based Porous Carbon for Supercapacitor

“…[ 16 ] The peak intensities of the bending vibration of H (≈800–950 cm −1 ) and the stretching vibration of H (≈3040 cm −1 ) on the aromatic group both weakened with the increase of temperature, which indicated that the PAHs of CTP were gradually condensed (carbon with a certain degree of graphitization was gradually formed) with the increase of temperature. [ 27,28 ]…”

Hetastarch-stabilized polypyrrole with hyperthermia-enhanced release and catalytic activity for synergistic antitumor therapy

“…As an important conjugated polymer, polypyrrole (PPy) is characterized by a large p-electronic delocalized backbone and inter-doping with oxidant complexes and stabilizers, which confers potent photothermal and photo-electronic advantages. [16][17][18][19] These features have been widely utilized in biological applications, such as photothermal therapy (PTT), drug delivery, tissue engineering, and biosensors. [20][21][22] For instance, various PPy morphologies have been developed for near infrared (NIR) laser-mediated PTT against malignant tumors, including ultrasmall PPy smaller than 10 nm, twodimensional PPy, hollow PPy, and so on.…”