Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention

Abstract

Cancer is a serious public health problem in the world and a major disease affecting human health. Dietary polyphenols have shown good potential in the treatment of various cancers. It is worth noting that cancer cells usually exhibit metabolic abnormalities of high glucose intake and inefficient utilization. AMPK is the key molecule in the regulation of energy metabolism and is closely related with obesity and diabetes. Recent studies indicate that AMPK also plays an important role in cancer prevention and regulating cancer‐related genes and pathways, and dietary polyphenols can significantly regulate AMPK activity. In this review, the progress of dietary polyphenols preventing carcinogenesis via AMPK pathway is systemically summarized. From the viewpoint of interfering energy metabolism, the anti‐cancer effects of dietary polyphenols are explained. AMPK pathway modulated by different dietary polyphenols affects pathways and target genes are summarized. Dietary polyphenols exert anti‐cancer effect through the target molecules regulated by AMPK, which broadens the understanding of polyphenols anti‐cancer mechanisms and provides value reference for the investigators of the novel field.

Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of <i>Rollinia dolabripetala</i> leaves

“…Plant-derived bioactive compounds, especially polyphenolic, have shown to reduce tumorigenesis, interfering in the initiation, promotion and progression of cancer (Dana et al, 2022;George et al, 2021;Hu et al, 2022) including melanoma (Enaru et al, 2021;Khan et al, 2020;Musial et al, 2021;Patra et al, 2021;Pinto et al, 2021). Cytotoxic phytocompounds present in different species of the genera Rollinia (Araujo et al, 2021;Cunha et al, 2009) and other annonaceous (George et al, 2021;Handayani & Yuzammi, 2021;Khan et al, 2020;Perrone et al, 2022;Rocha et al, 2021;Shehata et al, 2021) support the experimental results obtained here, with selective cytotoxic effect on normal cells (Ribeiro et al, 2018;Shehata et al, 2021).…”

“…Plants are an important source of natural compounds used for medicine, with considerable interest and special attention for their wide variety of bioactive metabolites. Several phytochemicals of different species have antitumor (Enaru et al, 2021;George et al, 2021;Hu et al, 2022;Khan et al, 2020;R.D.P. Nascimento et al, 2022;Patra et al, 2021) and antimicrobial activity (Christenhusz & Byng, 2016;Fernández et al, 2020;Marco et al, 2019;Vakayil et al, 2021).…”

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

“…On the other hand, some phenolic compounds such as daidzein and genistein exhibited controversial effects on the pathogenesis of hormone-associated cancers ( 399 ). Such incongruous results have still not been reported for other phenolic categories, and it is now believed that PPs displayed their health-promising effects by interacting with various receptors and signaling pathways ( 551 ). In this respect, the emerging scientific investigations reported that supplementation of antioxidants (vitamin E and N-acetylcysteine) in mice increased the progression of lung cancer by inducing P53-assisted oxidative stress ( 198 ).…”

Targeting lncRNA/Wnt axis by flavonoids: A promising therapeutic approach for colorectal cancer

“…Considering the numerous signal pathways involved in CRC metabolism, the exploration of multi‐target and safe natural bioactive compounds remained a priority (Ayan, Çetinkaya, Dursun, Güneş, & Şirin, 2021; Yang et al, 2021). Flavonoids are categorized as secondary metabolites, which were widely present in plant foods such as fruits, vegetables, whole grains, spices, herb plants, tea, and wine (Hu, Li, Cao, Guo, & Luo, 2021). In recent years, as dietary supplements or drug candidates, flavonoids are widely used to prevent CRC by targeting multiple signaling pathways in cancer metabolism, including signal pathway mediators such as oxidative stress, inflammation, and autophagy (Little, Combet, McMillan, Horgan, & Roxburgh, 2017).…”

“…Flavonoids are categorized as secondary metabolites, which were widely present in plant foods such as fruits, vegetables, whole grains, spices, herb plants, tea, and wine (Hu, Li, Cao, Guo, & Luo, 2021). In recent years, as dietary supplements or drug candidates, flavonoids F I G U R E 1 Risk factors and general molecular mechanisms of CRC.…”