Targeting bacterial biofilms: Design of a terpenoid-like library as non-toxic anti-biofilm compounds

Sall, Cheikh; Dombrowsky, Linda; Bottzeck, O.; Praud-Tabaries, Annie; Blache, Yves

doi:10.1016/j.bmcl.2010.12.134

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…Next, we highlighted the anti-melanogenic effects of PPEO through cell viability, cell morphology, intracellular melanin content, intracellular TYR activity and expression, and compared these results with those of the positive control (kojic acid). Previous studies have shown that the action mechanism of terpenoids in cells is related to the destruction of lipophilic compounds in biofilms [25,26]. Due to the high hydrophobicity of terpenoids, their toxic effects lead to swelling and enhanced fluidity and permeability of the cell membranes [27].…”

Section: Resultsmentioning

confidence: 99%

Anti-Oxidant and Anti-Melanogenic Properties of Essential Oil from Peel of Pomelo cv. Guan Xi

Peng

et al. 2019

Molecules

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Here, we investigated the anti-oxidant and anti-melanogenic effects of pomelo peel essential oil (PPEO) from pomelo cv. Guan Xi. The volatile chemical composition of PPEO was analyzed with gas chromatography–mass spectrometry (GC/MS). The most abundant component of PPEO was limonene (55.92%), followed by β-myrcene (31.17%), and β-pinene (3.16%). PPEO showed strong anti-oxidant activities against 2,2-diphenyl-2-picryhydrazyl (DPPH), 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate (ABTS) and superoxide anion free radicals. Based on the B16 melanoma cell system, the effects of PPEO on the viability and morphology of B16 cells and the production of melanin were evaluated. The results revealed that PPEO at concentrations below 50 μg/mL could decrease the melanin content without affecting cell viability and morphology. Intracellular tyrosinase (TYR) activity and Western blot analysis showed that PPEO could down-regulate the expression level of TYR in B16 cells and dose-dependently inhibit TYR activity (by a maximum of 64.54%). In conclusion, PPEO has good anti-oxidant and anti-melanogenic activity, and thus can be widely used as a natural antioxidant in the food, pharmaceutical, and cosmetic industries.

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Section: Resultsmentioning

confidence: 99%

Anti-Oxidant and Anti-Melanogenic Properties of Essential Oil from Peel of Pomelo cv. Guan Xi

Peng

et al. 2019

Molecules

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“…terpenoids) may directly impact BF, as observed from C. sempervirens (Cupressaceae) [32], Plectranthus amboinicus (Lamiaceae) [49] and Myrtaceae species [44]. A terpenic skeleton was used as basis to develop an anti-BF synthetic compound [50]. Cupressaceae is unrelated to Combretaceae and Myrtaceae, but the evolution of similar phytochemistry has facilitated similar antibacterial mechanisms, and species in these groups may be tapped as potential sources of novel anti-QS/BF antibiotic compounds.…”

Section: Discussionmentioning

confidence: 99%

Leveraging Phytochemicals: The Plant Phylogeny Predicts Sources of Novel Antibacterial Compounds

2019

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Aim: The goal of this study was to use phylogenetic evidence to determine plant families with high representation of antibacterial activity and identify potential sources to focus on for antibacterial drug discovery. Materials & methods: We reconstructed the molecular phylogeny of plant taxa with antibacterial activity and mapped antibacterial mechanisms of action on the phylogeny. Results: The phylogeny highlighted seven plant families (Combretaceae, Cupressaceae, Fabaceae, Lamiaceae, Lauraceae, Myrtaceae and Zingiberaceae) with disproportionately represented antibacterial activity. Phytochemicals produced were primarily involved in the disruption of the bacterial cell wall/membrane and inhibition of quorum sensing/biofilm production. Conclusion: The study provides phylogenetic evidence of seven plant families that should be examined as promising leads for novel antibacterial development.

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“…Isoprenyl 1,2,3-triazoles have shown promising and varied biological activities (Figure 2) such as antimicrobials, 9 antibiofilms, 10,11 antioxidants, 9 and antiparasitics. 12 Additionally they also displayed activity as geranylgeranyl transferase II, 13 geranylgeranyldiphosphate synthase, 14,15 farnesyltransferase, Ras and Rab geranylgeranyl transferase inhibitors.…”

mentioning

confidence: 99%

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

et al. 2017

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A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.

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Targeting bacterial biofilms: Design of a terpenoid-like library as non-toxic anti-biofilm compounds

Cited by 15 publications

References 18 publications

Anti-Oxidant and Anti-Melanogenic Properties of Essential Oil from Peel of Pomelo cv. Guan Xi

Anti-Oxidant and Anti-Melanogenic Properties of Essential Oil from Peel of Pomelo cv. Guan Xi

Leveraging Phytochemicals: The Plant Phylogeny Predicts Sources of Novel Antibacterial Compounds

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

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