Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors

Holden, Jeffrey K.; Lewis, Matthew; Cinelli, Maris A.; Abdullatif, Ziad; Pensa, Anthony V.; Silverman, Richard B.; Poulos, T.L.

doi:10.1021/acs.biochem.6b00786

Cited by 16 publications

(6 citation statements)

References 29 publications

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“…Considering antibacterial activity, especially against Pseudomonas aeruginosa , the decrease of the NOS2 protein level in HUVECs after SB exposure, it might be possible that the synthesis of NO by bacteria could also be reduced. One of the many proposed roles of NO in bacteria is to help protect the bacteria from host cell antibiotic-induced oxidative stress; therefore, the inhibition of bacterial nitric oxide synthase has been identified as a promising antibacterial strategy, especially for resistant bacteria [58].…”

Section: Discussionmentioning

confidence: 99%

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Bâldea

Tiperciuc

et al. 2019

Oxidative Medicine and Cellular Longevity

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Schiff bases (SBs) are chemical compounds displaying a significant pharmacological potential. They are able to modulate the activity of many enzymes involved in metabolism and are found among antibacterial, antifungal, anti-inflammatory, antioxidant, and antiproliferative drugs. A new thiazolyl-triazole SB was obtained and characterized by elemental and spectral analysis. The antibacterial and antifungal ability of the SB was evaluated against Gram-positive and Gram-negative bacteria and against three Candida strains. SB showed good antibacterial activity against L. monocytogenes and P. aeruginosa; it was two times more active than ciprofloxacin. Anti-Candida activity was twofold higher compared with that of fluconazole. The effect of the SB on cell viability was evaluated by colorimetric measurement on cell cultures exposed to various SB concentrations. The ability of the SB to modulate oxidative stress was assessed by measuring MDA, TNF-α, SOD1, COX2, and NOS2 levels in vitro, using human endothelial cell cultures exposed to a glucose-enriched medium. SB did not change the morphology of the cells. Experimental findings indicate that the newly synthetized Schiff base has antibacterial activity, especially on the Gram-negative P. aeruginosa, and antifungal activity. SB also showed antioxidant and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Bâldea

Tiperciuc

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…As one of the unique structures of heterocyclic compounds, 2‐aminoquinolines have attracted much attention from both medicinal and chemical scientists Moreover, the compounds with 2‐aminoquinoline motif exist widely in numerous pharmaceuticals and biological natural products . The early studies disclosed that the Chichibabin reaction is the direct strategy for the preparation of 2‐aminoquinolines (Scheme a) .…”

Section: Introductionmentioning

confidence: 99%

Copper‐Catalyzed Deoxygenative C‐2 Amination of Quinoline N‐Oxides

Wang

Han

et al. 2018

Eur J Org Chem

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“…Quinolines are an important synthons and ubiquitous motifs for the drug synthesis development and natural products (Cretton et al, 2016;Holden et al, 2016). Several efforts have been made in the past for an efficient, ecofriendly methods toward quinolines drug development (Batista et al, 2016;Zolfigol et al, 2006).…”

Section: Some Classical Quinoline Synthesis Methodsmentioning

confidence: 99%

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

et al. 2022

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The quinoline scaffolds are privileged for their numerous biological activities in the pharmaceutical field. This moiety constitutes a well‐known space in several marketed preparations. The quinoline scaffolds gained attention in modern days being an important chemical moiety in the identification, designing, and synthesis of novel potent derivatives. The current review is developed to shine the light on critical and significant insights on the quinoline derivatives possessing diverse biological activities such as analgesic, anti‐inflammatory, antialzheimer, anti‐convulsant, anti‐oxidant, antimicrobial, anti‐cancer activities and so on. A detailed summary of quinoline ring from its origin to the recent advancements regarding its synthesis, green chemistry approaches, patented methods, and its marketed drugs is presented in the review. We attempted to review the literature compiling the critical information that has potential to encourage fellow researchers and scientists for the design and development of quinoline scaffold based active molecules that have improved therapeutic performance along with profound pharmacological properties.

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Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors

Cited by 16 publications

References 29 publications

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Copper‐Catalyzed Deoxygenative C‐2 Amination of Quinoline N‐Oxides

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

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