Targeting Blood Vessel Stiffness to Protect Kidney Function

Dhaun, Neeraj; Webb, David J.

doi:10.2215/cjn.11331015

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…Strengths of our study are the large sample size with extensive phenotyping, including data on four different coagulation factors and data on three different measures of vascular function. Both albuminuria and arterial stiffness can be considered to reflect systemic vascular injury; albuminuria may potentially serve as a surrogate marker of systemic endothelial dysfunction [33], and arterial stiffness as a marker of intima-medial calcification [11,34].…”

Section: Discussionmentioning

confidence: 99%

Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population

Dekkers

Mutsert

Vries

et al. 2018

Journal of Thrombosis and Haemostasis

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Background Impaired renal and vascular function have been associated with venous thrombosis, but the mechanism is unclear. Objectives We investigated whether estimated glomerular filtration rate (eGFR), urinary albumin-creatinine ratio (UACR), and pulse wave velocity (PWV) are associated with a procoagulant state. Methods In this cross-sectional analysis of the NEO Study, eGFR, UACR, fibrinogen, and coagulation factors (F)VIII, FIX and FXI were determined in all participants (n = 6536), and PWV was assessed in a random subset (n = 2433). eGFR, UACR and PWV were analyzed continuously and per percentile: per six categories for eGFR (> 50 [reference] to < 1st) and UACR (< 50 [reference] to > 99th), and per four categories (< 50 [reference] to > 95th percentile) for PWV. Linear regression was used and adjusted for age, sex, total body fat, smoking, education, ethnicity, total cholesterol, C-reactive protein (CRP) and vitamin K antagonists use (FIX). Results Mean age was 55.6 years, mean eGFR 86.0 (12SD) mL 1.73 m ² and median UACR 0.4 mg mmol (25th, 75th percentile; 0.3, 0.7). All coagulation factors showed a procoagulant shift with lower renal function and albuminuria. For example, FVIII was 22 IU dL (95% CI, 13-32) higher in the eGFR < 1st percentile compared with the > 50th percentile, and FVIII was 12 IU dL (95% CI, 3-22) higher in the UACR > 99th percentile compared with the < 50th percentile. PWV was positively associated with coagulation factors FIX and FXI in continuous analysis; per m/s difference in PWV, FIX was 2.0 IU dL (95% CI, 0.70-3.2) higher. Conclusions Impaired renal and vascular function was associated with higher levels of coagulation factors, underlining the role of renal function and vascular function in the development of venous thrombosis.

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Section: Discussionmentioning

confidence: 99%

Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population

Dekkers

Mutsert

Vries

et al. 2018

Journal of Thrombosis and Haemostasis

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“…Od temeljne je važnosti povezanost inzulinske rezistencije s endotelnom disfunkcijom žila, što je začetnik aterosklerotskoga procesa 22, 23 . U stanju inzulinske rezistencije, koja je temeljni patofiziološki čimbenik metaboličkog sindroma i pretilosti, smanjuje se sinteza dušičnog oksida i narušuje se ravnoteža u korist vazokonstriktornih čimbenika i oksidativnoga stresa koji se smatra i osnovicom vaskularne demencije 24 .…”

Section: Utjecaj Debljine Na Razvoj Demencijeunclassified

“…Crucial is the association of insulin resistance and vascular endothelial dysfunction for triggering the process of atherosclerosis 22, 23 . In the state of insulin resistance, which is a basic pathophysiological factor of the metabolic syndrome and obesity, the synthesis of nitric oxide is decreased and the balance impaired in favor of vasoconstrictory factors and oxidative stress, which is considered the basis of vascular dementia 24 .…”

Section: Impact Of Obesity On Development Of Dementiamentioning

confidence: 99%

Association of mental health, obesity and arterial hypertension

Prkačin

Zorko

Herceg-Čavrak

2017

Cardiologia Croatica

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Poveznica mentalnoga zdravlja, pretilosti i arterijske hipertenzijeAssociation of mental health, obesity and arterial hypertension SAŽETAK: Napredak u prevenciji bolesti i zdravstvenoj zaštiti produžio je očekivano trajanje života i time povećao globalno opterećenje bolestima. Tako su nezarazne bolesti, uključujući arterijsku hipertenziju, dijabetes i demenciju, nedostatno prepoznat problem svjetske populacije. Demencija povezana sa starenjem ireverzibilno je stanje koje se očituje progresivnim padom kognitivnih funkcija te se smatra jednim od vodećih zdravstvenih problema novog doba. U zbrinjavanju ove fragilne populacije potreban je interdisciplinaran pristup jer su u osnovi patofiziološkoga zbivanja hiperinzulinemija i oksidativni stres na razini cijelog organizma, a ne izoliranog samo jednog organa. SUMMARY:The progress in disease prevention and health care has prolonged life expectancy, thus increasing the global disease burden. The non-communicable diseases such as arterial hypertension, diabetes mellitus and dementia have been recognized as an inadequately clarified problem in the population all over the world. Senile dementia is an irreversible condition manifested by progressive decline of cognitive functions and considered as one of the leading health problems today. Proper care for this fragile population requires interdisciplinary approach because the pathophysiological events are underlain by hyperinsulinemia and oxidative stress at the whole body level rather than isolated to a single organ.KLJUČNE RIJEČI: mentalno zdravlje, hiperinzulinemija, oksidativni stres, zdravlje srca i bubrega.

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Targeting Blood Vessel Stiffness to Protect Kidney Function

Cited by 2 publications

References 26 publications

Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population

Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population

Association of mental health, obesity and arterial hypertension

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