Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Talib, Wamidh H.; Awajan, Dima; Alqudah, Abdelrahim; Alsawwaf, Razan; Althunibat, Raha; Abu AlRoos, Mahmoud; Al Safadi, Ala’a; Abu Asab, Sharif; Hadi, Rawan W.; Al Kury, Lina T.

doi:10.3390/molecules29061373

Cited by 12 publications

(2 citation statements)

References 163 publications

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“…To gain insight into the possible molecular basis behind the anti-proliferative ability of CFT-1, we referred to the available knowledge about the molecular target(s) of EGCG. According to previous studies, EGCG has been shown to inhibit telomerase activity considerably in several different cancer cell lines by repressing the target mRNA expression [ 33 , 34 ]. Telomerase seems to play a primary role in the cancer-fighting virtues of EGCG.…”

Section: Resultsmentioning

confidence: 99%

Functional Tea Extract Inhibits Cell Growth, Induces Apoptosis, and Causes G0/G1 Arrest in Human Hepatocellular Carcinoma Cell Line Possibly through Reduction in Telomerase Activity

Chen,

Xiang

et al. 2024

Foods

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The functional tea CFT-1 has been introduced into China as a nutraceutical beverage according to the “Healthy China” national project. The effects on human hepatocellular carcinoma (HCC) cells remain unclear and were investigated with the functional tea extract (purity > 98%). The morphological changes in the cells were observed with microscopes. Cell proliferation, migration, cycle distribution, and apoptotic effects were assessed by MTT, Transwell assays, and flow cytometry, respectively, while telomerase inhibition was evaluated with telomerase PCR ELISA assay kits. The CFT-1 treatment resulted in cell shrinkage, nuclear pyknosis, and chromatin condensation. CFT-1 suppressed the growth of Hep3B cells with IC50 of 143 μg/mL by inducing apoptosis and G0/G1 arrest in Hep3B cells. As for the molecular mechanism, CFT-1 treatment can effectively reduce the telomerase activity. The functional tea extract inhibits cell growth in human HCC by inducing apoptosis and G0/G1 arrest, possibly through a reduction in telomerase activity. These results indicate that CFT-1 extract exhibited in vitro anticancer activities and provided insights into the future development and utilization of CFT-1 as functional foods to inhibit the proliferation of HCC cells.

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Section: Resultsmentioning

confidence: 99%

Functional Tea Extract Inhibits Cell Growth, Induces Apoptosis, and Causes G0/G1 Arrest in Human Hepatocellular Carcinoma Cell Line Possibly through Reduction in Telomerase Activity

Chen,

Xiang

et al. 2024

Foods

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show abstract

“…Genistein from soybeans (Glycine max) enhances p53 reactivation, promoting cell cycle arrest and apoptosis. Its estrogenic properties may also contribute to its anticancer effects in hormone-responsive cancers [22]. Their multi-target nature may help address the complexity of cancer biology and reduce the likelihood of resistance development.…”

Section: Introductionmentioning

confidence: 99%

Computational Screening ofZanthoxylum armatumDC Phytochemicals for inhibiting Mutant P53 in Throat Cancer Therapy

Taring,

Singpho,

Lamu

et al. 2024

Preprint

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Aim: To investigate the potential of phytochemicals from Zanthoxylum armatum DC in targeting mutant p53 as a therapeutic strategy for throat cancer using an in-silico approach. Background: Throat cancer is increasingly associated with mutations in the TP53 gene, leading to dysfunctional p53 proteins. Current synthetic drugs targeting mutant p53 face challenges of toxicity and off-target effects, necessitating the exploration of alternative natural compounds. Methods: We employed molecular docking, molecular dynamics simulations, MMPBSA analysis, and ADMET studies to identify and characterize effective inhibitors of mutant p53 from Z. armatum DC phytochemicals. Results: Three compounds - Z3, Z7, and Z33 - demonstrated superior binding affinities to mutant p53 compared to the commercial drug Prima. These phytochemicals induced more compact and stable protein conformations, with Z3 and Z7 notably restricting active site residual motion. MMPBSA analysis confirmed favourable binding energetics, while ADMET studies indicated drug-like properties with potentially lower toxicity than Prima. Conclusion: This study provides compelling evidence for the potential of Z. armatum DC phytochemicals, particularly Z3 and Z7, as novel therapeutic agents targeting mutant p53 in throat cancer. These findings offer a foundation for future experimental validation and drug development efforts.

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An Updated Review Summarizing the Anticancer Potential of Poly(Lactic‐co‐Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers

Pandey,

Verma,

Lakhanpal

et al. 2024

Biopolymers

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The utilization of nanoformulations derived from natural products for the treatment of many human diseases, including cancer, is a rapidly developing field. Conventional therapies used for cancer treatment have limited efficacy and a greater number of adverse effects. Hence, it is imperative to develop innovative anticancer drugs with superior effectiveness. Among the diverse array of natural anticancer compounds, resveratrol, curcumin, and epigallocatechin gallate (EGCG) have gained considerable attention in recent years. Despite their strong anticancer properties, medicinally significant phytochemicals such as resveratrol, curcumin, and EGCG have certain disadvantages, such as limited solubility in water, stability, and bioavailability problems. Encapsulating these phytochemicals in poly(lactic‐co‐glycolic acid) (PLGA), a polymer that is nontoxic, biodegradable, and biocompatible, is an effective method for delivering medication to the tumor location. In addition, PLGA nanoparticles can be modified with targeting molecules to specifically target cancer cells, thereby improving the effectiveness of phytochemicals in fighting tumors. Combining plant‐based medicine (phytotherapy) with nanotechnology in a clinical environment has the potential to enhance the effectiveness of drugs and improve the overall health outcomes of patients. Therefore, it is crucial to have a comprehensive understanding of the different aspects and recent advancements in using PLGA‐based nanocarriers for delivering anticancer phytochemicals. This review addresses the most recent advancements in PLGA‐based delivery systems for resveratrol, EGCG, and curcumin, emphasizing the possibility of resolving issues related to the therapeutic efficacy and bioavailability of these compounds.

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Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Cited by 12 publications

References 163 publications

Functional Tea Extract Inhibits Cell Growth, Induces Apoptosis, and Causes G0/G1 Arrest in Human Hepatocellular Carcinoma Cell Line Possibly through Reduction in Telomerase Activity

Functional Tea Extract Inhibits Cell Growth, Induces Apoptosis, and Causes G0/G1 Arrest in Human Hepatocellular Carcinoma Cell Line Possibly through Reduction in Telomerase Activity

Computational Screening ofZanthoxylum armatumDC Phytochemicals for inhibiting Mutant P53 in Throat Cancer Therapy

An Updated Review Summarizing the Anticancer Potential of Poly(Lactic‐co‐Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers

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