Targeting Cancer Using Nanocarriers

Landesman-Milo, Dalit; Qassem, Shahd; Peer, Dan

doi:10.1007/978-1-4939-3634-2_7

Cited by 3 publications

(2 citation statements)

References 151 publications

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“…Nanogels with a mean diameter of approximately 200 nm were prepared by cross-linking of thiolated Hep, followed by induction of glutathione-mediated release of Hep, which lead to the inhibition of cancer cell proliferation (Bae et al, 2008). Moreover, HA was conjugated to lipid-based NP for the specific delivery of siRNA to cancer cells that overexpress CD44, to induce gene silencing (Landesman-Milo et al, 2013). Physically formed NP of chitosan and CS were used successfully for the release of platelet lysate, which represents a promising system for bone-TE (Santo et al, 2012).…”

Section: Glycosaminoglycans As a Component Of Micro-and Nanoparticlesmentioning

confidence: 99%

Medical application of glycosaminoglycans: a review

Köwitsch

Zhou

Groth

2017

J Tissue Eng Regen Med

183

145

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The characteristic molecular composition of the different glycosaminoglycans (GAGs) is related to their role as structural components and regulators of a multitude of functions of proteins, cells and tissues in the human body. Therefore, it is not surprising that GAGs are widely used as coating materials for implants, components of 3D-constructs such as tissue engineering scaffolds and hydrogels, but also as diagnostic devices such as biosensors and in controlled release applications. Beside a physisorption or encapsulation of GAGs, these applications often require their chemical modification to allow a stable covalent attachment on surfaces or cross-linking reactions with other molecules. Then, the preservation of the functionality of GAGs under maintenance of their biocompatibility is a challenging task and must be addressed in accordance with the designated field of application. Here, we will give a brief overview on structure and biological functions of GAGs, different methods of their activation and immobilization, the recent progress in GAG-related biomaterials development, as well as some examples of their application in the field of tissue engineering and regenerative medicine.

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Section: Glycosaminoglycans As a Component Of Micro-and Nanoparticlesmentioning

confidence: 99%

Medical application of glycosaminoglycans: a review

Köwitsch

Zhou

Groth

2017

J Tissue Eng Regen Med

183

145

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“…One goal of targeted nanomedicine is to construct nanoparticles that do reach their target and release the drug they are carrying at that site, typically in cancerous tissues, so that the cancer can be treated without there being severe systemic side-effects [Singh & Lillard 2009]. Nanoparticle-based drug delivery has the potential of increasing the dose and targeted toxicity of drugs reaching the cancer while protecting healthy cells from their toxic effects [Landesman-Milo, Qassem et al 2016].…”

Section: Introductionmentioning

confidence: 99%

The Role of “Missile” and “Targeting” Metaphors in Nanomedicine

Oftedal¹

2019

philosophiascientiae

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Dans cet article, je soutiens que les métaphores « missile » et « ciblage » dans la recherche sur les médicaments à base de nanoparticules jouent différents rôles. Je soutiens que le « missile » joue un rôle scientifique marginal et un rôle plus central dans la communication, tandis que le « ciblage » est devenu une métaphore organisatrice dans le domaine de la recherche. La raison, je le suggère, est que le ciblage est l'explanandum principal du domaine et que cette métaphore continue d'être pertinente même lorsque la nanomédecine mûrit pour s'attaquer à des problèmes plus complexes. Enfin, je discute des suggestions récentes de nouvelles métaphores axées sur la complexité, et je suggère que le rôle significatif des modèles simplificateurs et le besoin réel de tels modèles peuvent expliquer pourquoi les métaphores de complexité n'ont pas retenu l'attention des chercheurs.

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