Targeting chromosomal instability and aneuploidy in cancer

Bhatia, Sugandha; Khanna, Kum Kum; Duijf, Pascal H.G.

doi:10.1016/j.tips.2024.01.009

Trends in Pharmacological Sciences

2024

DOI: 10.1016/j.tips.2024.01.009

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Targeting chromosomal instability and aneuploidy in cancer

Sugandha Bhatia,

Kum Kum Khanna,

Pascal H.G. Duijf

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Cited by 3 publications

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A complex systems approach to mosaic loss of the Y chromosome

Guo,

Dai

2024

GeroScience

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A complex systems approach to mosaic loss of the Y chromosome

Guo,

Dai

2024

GeroScience

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Exploration of inhibitors targeting KIF18A with ploidy-specific lethality

Chen,

Le,

et al. 2024

Drug Discovery Today

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Patterns of Aneuploidy and Signaling Consequences in Cancer

Zhakula-Kostadinova,

Taylor

2024

Cancer Research

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Aneuploidy, or a change in the number of whole chromosomes or chromosome arms, is a near-universal feature of cancer. Chromosomes affected by aneuploidy are not random, with observed cancer-specific and tissue-specific patterns. Recent advances in genome engineering methods have allowed the creation of models with targeted aneuploidy events. These models can be used to uncover the downstream effects of individual aneuploidies on cancer phenotypes including proliferation, apoptosis, metabolism, and immune signaling. Here, we review the current state of research into the patterns of aneuploidy in cancer and their impact on signaling pathways and biological processes.

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Targeting chromosomal instability and aneuploidy in cancer

Cited by 3 publications

References 116 publications

A complex systems approach to mosaic loss of the Y chromosome

A complex systems approach to mosaic loss of the Y chromosome

Exploration of inhibitors targeting KIF18A with ploidy-specific lethality

Patterns of Aneuploidy and Signaling Consequences in Cancer

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