Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15

Chen, Hao; Huang, Shi‐Wei; Guan, Fanlu; Han, Sisi; Ye, Fanhao; Li, Xun; You, Liyi

doi:10.1155/2022/8208471

Cited by 4 publications

(5 citation statements)

References 39 publications

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“…These data suggested the negative association between lnc‐ANRIL levels and cell proliferation. In addition, studies have shown that lncRNA ANRIL triggers myocardial cell apoptosis in acute myocardial infarction through IL‐33/ST2 signal transduction 28 . Long‐chain noncoding RNA ANRIL regulates apoptosis in human trabecular meshwork cells by targeting microRNA‐7 29 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, studies have shown that lncRNA ANRIL triggers myocardial cell apoptosis in acute myocardial infarction through IL-33/ST2 signal transduction. 28 Long-chain noncoding RNA ANRIL regulates apoptosis in human trabecular meshwork cells by targeting microRNA-7. 29 Similarly, in our study, we also found that lnc-ANRIL can induce apoptosis in MAC-T cells.…”

Section: Discussionmentioning

confidence: 99%

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Lnc‐ANRIL modulates the immune response associated with NF‐κB pathway in LPS‐stimulated bovine mammary epithelial cells

Lu,

Gu,

et al. 2023

Immunity Inflam & Disease

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BackgroundThe antisense noncoding RNA in the INK4 locus (ANRIL) has been confirmed related to multiple disease progression, but the role and exact mechanisms of lnc‐ANRIL in lipopolysaccharide (LPS)‐induced inflammation of bovine mammary epithelial cells (MAC‐T) remain unclear.AimsThis manuscript focused on expounding the functional role of lnc‐ANRIL through experiments performed in MAC‐T.MethodsAt the in vitro level, we established a Bovine mammary epithelial cell (BMEC) cell model of mastitis by LPS treatment. Transfection of siRNA was examined by immunofluorescence localization and RT‐qPCR. CCK8, clonogenic assay and EdU were used to detect the proliferation ability of the cells. Cell cycle and apoptosis were detected by flow cytometry and Western blot. The levels of inflammatory factors and oxidative stress markers were detected by ELISA kits.ResultsCell Counting Kit‐8, colony formation, and 5‐ethynyl‐20‐deoxyuridine were adopted and the data illustrated that LPS could significantly suppress the cell proliferation, while knockdown of lnc‐ANRIL expression obviously promoted MAC‐T cell proliferation compared with LPS or LPS + si‐NC group. Flow cytometry analysis demonstrated that lnc‐ANRIL could induce MAC‐T cell apoptosis. In addition, downregulation of lnc‐ANRIL affected LPS‐induced immune response by regulating inflammatory factor expressions and modulating the nuclear factor kappa B (NF‐κB) axis in MAC‐T cells.ConclusionOur results suggest that lnc‐ANRIL is involved in the regulation of cell proliferation, cell cycle, and cell apoptosis of MAC‐T cells, and plays an important role in the inflammatory and immune response of MAC‐T cells through the regulation of the NF‐κB pathway, proposing new therapeutic strategies for the treatment of innate immune response‐related disease such as bovine mastitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lnc‐ANRIL modulates the immune response associated with NF‐κB pathway in LPS‐stimulated bovine mammary epithelial cells

Lu,

Gu,

et al. 2023

Immunity Inflam & Disease

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“…Seven lncRNAs (RP11-68I3.11, AC068831.6, RP11-133L14.5, PAX8-AS1, RP11-259K15.2, RP11-203M5.8, and LINC01254) have been identified in patients with acute coronary syndrome and may be potential biomarkers of myocardial infarction [ 184 ]. In addition, circulating ENST00000538705.1 has been found to facilitate the progression of acute coronary syndrome through modulation of ALOX15 [ 185 ]. Knockdown of ENST00000538705.1 or ALOX15 reduces myocardial damage, decreases serum total cholesterol and LDL levels, and increases HDL levels in rats with myocardial infarction.…”

Section: The Significance Of Long Non-coding Rnasmentioning

confidence: 99%

“…Knockdown of ENST00000538705.1 or ALOX15 reduces myocardial damage, decreases serum total cholesterol and LDL levels, and increases HDL levels in rats with myocardial infarction. This allows ENST00000538705.1 and ALOX15 to be considered as potential molecular targets for acute coronary syndrome therapy [ 185 ].…”

Section: The Significance Of Long Non-coding Rnasmentioning

confidence: 99%

Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis

Kotlyarov

2022

Genes

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Atherosclerosis is one of the most important medical and social problems of modern society. Atherosclerosis causes a large number of hospitalizations, disability, and mortality. A considerable amount of evidence suggests that inflammation is one of the key links in the pathogenesis of atherosclerosis. Inflammation in the vascular wall has extensive cross-linkages with lipid metabolism, and lipid mediators act as a central link in the regulation of inflammation in the vascular wall. Data on the role of genetics and epigenetic factors in the development of atherosclerosis are of great interest. A growing body of evidence is strengthening the understanding of the significance of gene polymorphism, as well as gene expression dysregulation involved in cross-links between lipid metabolism and the innate immune system. A better understanding of the genetic basis and molecular mechanisms of disease pathogenesis is an important step towards solving the problems of its early diagnosis and treatment.

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“…Coronary heart disease (CHD) is a pivotal reason for reduced quality of life, disability, and death [ 1 ]. The most dangerous and deadly form of CHD is acute coronary syndrome (ACS) [ 2 ]. ACS is a series of clinical syndromes caused by rupture or erosion of atherosclerotic plaques, resulting in narrowing or occlusion of the coronary artery lumen, causing acute ischemia or necrosis of the myocardium [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA SNHG7 serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after percutaneous coronary intervention

Liao,

Han,

Zhang

2024

J Cardiothorac Surg

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Background Acute coronary syndrome (ACS) is one of the common causes of cardiovascular death. The related lncRNAs were novel approaches for early diagnosis and intervention. This paper focused on the clinical function of SNHG7 for patients after PCI. Methods The expression of SNHG7 was assessed in ACS patients. The predictive roles of SNHG7 were unveiled by the ROC curve. The relationship between SNHG7 and Gensini scores was judged by Pearson analysis. One-year follow-up was conducted and all patients were catalogued into different groups based on the prognosis. The qRT-PCR, K-M curve, and Cox regression analysis were performed to document the prognostic significance of SNHG7. Results SNHG7 was highly expressed in ACS and its three subtypes. SNHG7 showed a certain value in predicting ACS, UA, NSTEMI, and STEMI. Gensini is a closely correlated indicator of SNHG7. The declined expression of SNHG7 was observed in the non-MACE and survival groups. The risk of MACE and death was increased in the group with high expression of SNHG7. SNHG7 was an independent biomarker in patients with ACS after PCI. Conclusions SNHG7 might be a diagnostic and prognostic tool for ACS patients.

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Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15

Cited by 4 publications

References 39 publications

Lnc‐ANRIL modulates the immune response associated with NF‐κB pathway in LPS‐stimulated bovine mammary epithelial cells

Lnc‐ANRIL modulates the immune response associated with NF‐κB pathway in LPS‐stimulated bovine mammary epithelial cells

Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis

Long non-coding RNA SNHG7 serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after percutaneous coronary intervention

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