Targeting collagen for diagnostic imaging and therapeutic delivery

Abstract

As the most abundant protein in mammals and a major structural component in extracellular matrix, collagen holds a pivotal role in tissue development and maintaining the homeostasis of our body. Persistent disruption to the balance between collagen production and degradation can cause a variety of diseases, some of which can be fatal. Collagen remodeling can lead to either an overproduction of collagen which can cause excessive collagen accumulation in organs, common to fibrosis, or uncontrolled degradation of collagen seen in degenerative diseases such as arthritis. Therefore, the ability to monitor the state of collagen is crucial for determining the presence and progression of numerous diseases. This review discusses the implications of collagen remodeling and its detection methods with specific focus on targeting native collagens as well as denatured collagens. It aims to help researchers understand the pathobiology of collagen-related diseases and create novel collagen targeting therapeutics and imaging modalities for biomedical applications.

Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression

“…Anti-TIMP-1 monoclonal antibodies have been shown to effectively localize in neoplastic tissues and provide an opportunity for drug targeting[219]. Collagen-mimetic peptides (CMPs) are shown to preferentially bind to denatured collagen via a triple helical peptide assembly and provide one of the most intriguing avenues for targeting MMP-induced effects in cancer drug delivery[220,221] (see Figure 3). Cleaved CD44 is known to be targeted by hyaluronic acid and has been investigated for drug delivery applications with promising results in the circumvention of chemoresistance[222].…”

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

“…Additionally, we discuss novel technologies based on thermoplastic processes that could be applied, likewise, as marine collagen treatment.2 of 23 protective colloid functions and film-forming capacity. Also, collagen is a good surface-active agent, with its ability to penetrate lipid-free interfaces [2].Collagen can be utilized in a variety of applications because of its biocompatibility and excellent degradability [3,4]. Furthermore, it is known that collagen is a molecule with weak immunogenicity, which decreases the possibilities of rejection when it is ingested or injected into a different body.…”

“…Collagen can be utilized in a variety of applications because of its biocompatibility and excellent degradability [3,4]. Furthermore, it is known that collagen is a molecule with weak immunogenicity, which decreases the possibilities of rejection when it is ingested or injected into a different body.…”

Imaging the Cardiac Extracellular Matrix

“…In lung and liver models, other peptide-based probes accumulate in fibrotic tissue ([14, 78], p. 201). There have been few other probes demonstrated in the literature, but a recent review has highlighted potential targets for collagen probes [72]. These targets include intact collagens I, II, and IV but also include degraded collagens I–V, which are found in fibrotic tissue and other sites of collagen remodeling.…”