Targeting connexin hemichannels to treat temporal lobe epilepsy

Kiani, Lisa

doi:10.1038/s41582-022-00752-4

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Connexins As Hemichannels1

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2023

2024

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Cited by 3 publications

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“…However, in vertebrates, other than connexins, there is no other protein family that has acquired the evolutionary advantage of direct and regulated intercellular exchange of signaling molecules barring the exception that pannexin 1 potentially acquires this capacity in rare situations ( 26 , 27 ). Nevertheless, overwhelming experimental evidence now points to cell surface connexin hemichannels having key roles in normal chordate physiology, pathology, and tissue injury, all of which are reviewed in detail elsewhere ( 28 , 29 , 30 , 31 ).…”

Section: Connexins As Hemichannelsmentioning

confidence: 99%