Targeting CXCL5 in Pancreatic Cancer Cells Inhibits Cancer Xenograft Growth by Reducing Proliferation and Inhibiting EMT Progression

Wang, Zhengzheng; Li, Xiaoting; Liu, Qingjun; Zhou, Jin-xue

doi:10.1007/s10620-022-07529-1

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…Similarly, Wang et al identified that CXCL5 was increased in human pancreatic tissue compared to the normal pancreas, and the knockdown of CXCL5 in pancreatic cancer cell lines reduced the proliferation and migration ability of cells [68]. Critically, knockdown significantly decreased the growth of xenograft tumors in vivo, suggesting CXCL5 expression by pancreatic cancer cells is necessary not only for metastasis, but also for optimal cell proliferation [68]. Further supporting that CXCL5 is secreted by epithelial pancreatic cancer cells, Chao et al, using tumor-bearing KPC and KPC with the Rosa LSL-YFP -allele (KPCY) mice, found that the CXCL5 expression was primarily concentrated in the tumor as opposed to the stroma [69].…”

Section: Cxcl5mentioning

confidence: 89%

“…Critically, CXCL5 production and TAN accumulation helped promote cancer cell invasion in in vitro assays [67]. Similarly, Wang et al identified that CXCL5 was increased in human pancreatic tissue compared to the normal pancreas, and the knockdown of CXCL5 in pancreatic cancer cell lines reduced the proliferation and migration ability of cells [68]. Critically, knockdown significantly decreased the growth of xenograft tumors in vivo, suggesting CXCL5 expression by pancreatic cancer cells is necessary not only for metastasis, but also for optimal cell proliferation [68].…”

Section: Cxcl5mentioning

confidence: 96%

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The Role of Chemokines in Orchestrating the Immune Response to Pancreatic Ductal Adenocarcinoma

Lekan,

Weiner

2024

Cancers

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Chemokines are small molecules that function as chemotactic factors which regulate the migration, infiltration, and accumulation of immune cells. Here, we comprehensively assess the structural and functional role of chemokines, examine the effects of chemokines that are present in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME), specifically those produced by cancer cells and stromal components, and evaluate their impact on immune cell trafficking, both in promoting and suppressing anti-tumor responses. We further explore the impact of chemokines on patient outcomes in PDAC and their role in the context of immunotherapy treatments, and review clinical trials that have targeted chemokine receptors and ligands in the treatment of PDAC. Lastly, we highlight potential strategies that can be utilized to harness chemokines in order to increase cytotoxic immune cell infiltration and the anti-tumor effects of immunotherapy.

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Section: Cxcl5mentioning

confidence: 89%

Section: Cxcl5mentioning

confidence: 96%

The Role of Chemokines in Orchestrating the Immune Response to Pancreatic Ductal Adenocarcinoma

Lekan,

Weiner

2024

Cancers

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“…CXCL5 facilitates the growth and spread of pancreatic cancer by augmenting the proliferation, migration, and invasion of malignant cells. The process of EMT is involved in both the initiation and progression of pancreatic cancer, as well as its resistance to chemotherapy ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

The lncRNA UCA1 Enhances Pancreatic Cancer EMT by Regulating miR-708-5p and miR-135b-5p: A Bioinformatics Approach

Askari,

Pirouz,

Mafikandi

et al. 2024

ijph

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Background: Pancreatic cancer (PC) is an exceedingly malignant ailment that is not only characterized by its insidious onset and rapid progression but also by its poor therapeutic effects. Recently, emerging evidence has shed light on the significant role that non-coding RNAs (ncRNAs), particularly long ncRNAs (lncRNAs) and microRNAs (miRNAs), play in the pathogenesis of PC. This investigation aimed to construct a network of interactions between miRNAs, lncRNAs, and mRNAs, as well as to perform correlation analyses in the context of PC. Methods: This study carried out in Kerman City, southeastern Iran in 2023. We utilized the GSE119794 dataset from the Gene Expression Omnibus (GEO) to analyze differentially expressed lncRNAs (DE-lncRNAs), miRNAs (DE-miRNAs), and mRNAs (DE-mRNAs). Following the identification of the DE-lncRNAs, DE-mRNAs, and DE-miRNAs, we proceeded to examine differentially expressed epithelial-mesenchymal transition (EMT) genes. Subsequently, we utilized the RNAInter database to predict interactions among lncRNAs, miRNAs, and mRNAs. Finally, we employed Cytoscape to visualize and analyze the constructed network. Results: 14 DE-lncRNAs, 14 DE-miRNAs, 545 DE-mRNAs, and 65 DE-EMT from pancreatic cancer and its adjacent tissue RNA-Seq data were identified. 1184 EMT genes from dbEMT were obtained, among which 65 DE-EMT were assigned as EMT genes and correlated with tumor progression. One functional lncRNA (UCA1) was identified as a key functional lncRNA. The area under the ROC curve (AUC) of UCA1 and miR-708-5p were 0.79 and 0.86, respectively. Thus, it is reasonable to believe that this prognostic risk model helps predict PC metastasis. Conclusion: UCA1 is a new lncRNA linked with EMT in PC and contributes to a better knowledge of the regulatory mechanisms related to lncRNAs in PC.

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“…A defining property of chemokines in the immune system is their ability to influence cell migration. Within tumors, CXCR2 ligands are capable of inducing EMT, a phenomenon that has been demonstrated in vitro with breast cancer cells (CXCL8/IL-8) [85], colon cancer cells (CXCL5) [86], hepatocellular carcinoma cells (CXCL5) [87], ovarian cancer cells (CXCL8/IL-8) [88], pancreatic cancer cells (CXCL5) [89], and prostate cancer cells (CXCL1) [90].…”

Section: Correlation Between the Expression Of Cxcr2 Ligands And Emtmentioning

confidence: 94%

Bioinformatic Analysis of the CXCR2 Ligands in Cancer Processes

Korbecki,

Bosiacki,

Chlubek

et al. 2023

IJMS

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Human CXCR2 has seven ligands, i.e., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8/IL-8—chemokines with nearly identical properties. However, no available study has compared the contribution of all CXCR2 ligands to cancer progression. That is why, in this study, we conducted a bioinformatic analysis using the GEPIA, UALCAN, and TIMER2.0 databases to investigate the role of CXCR2 ligands in 31 different types of cancer, including glioblastoma, melanoma, and colon, esophageal, gastric, kidney, liver, lung, ovarian, pancreatic, and prostate cancer. We focused on the differences in the regulation of expression (using the Tfsitescan and miRDB databases) and analyzed mutation types in CXCR2 ligand genes in cancers (using the cBioPortal). The data showed that the effect of CXCR2 ligands on prognosis depends on the type of cancer. CXCR2 ligands were associated with EMT, angiogenesis, recruiting neutrophils to the tumor microenvironment, and the count of M1 macrophages. The regulation of the expression of each CXCR2 ligand was different and, thus, each analyzed chemokine may have a different function in cancer processes. Our findings suggest that each type of cancer has a unique pattern of CXCR2 ligand involvement in cancer progression, with each ligand having a unique regulation of expression.

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Targeting CXCL5 in Pancreatic Cancer Cells Inhibits Cancer Xenograft Growth by Reducing Proliferation and Inhibiting EMT Progression

Cited by 9 publications

References 26 publications

The Role of Chemokines in Orchestrating the Immune Response to Pancreatic Ductal Adenocarcinoma

The Role of Chemokines in Orchestrating the Immune Response to Pancreatic Ductal Adenocarcinoma

The lncRNA UCA1 Enhances Pancreatic Cancer EMT by Regulating miR-708-5p and miR-135b-5p: A Bioinformatics Approach

Bioinformatic Analysis of the CXCR2 Ligands in Cancer Processes

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