TARGETING DNA METHYL TRANSFERASE 1[Dnmt1]- IN DIABETIC NEPHROPATHY

Abstract

Dnmt1 is necessary for HDACs activity and recruits various HDACs and transcription factor responsible for podocyte injury in Diabetic nephropathy, targeting Dnmt1 may prevent podocyte injury and decrease albuminuria, mesangial matrix expansion and glomerular hypertrophy. Hence Dnmt1 are novel targets.

Berbamine application beyond cancer

“…A new potential target in diabetic nephropathy has been identified. [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] The Wnt/β-catenin signaling pathway is involved in mesangial cell extracellular matrix (ECM) production (MCs). 58 Through the JNK/NF-B/NADPH oxidase/ROS pathway, high glucose promotes renal mesangial cell proliferation and fibronectin expression.…”