2018
DOI: 10.1002/jcp.27047
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Targeting drugs to APJ receptor: From signaling to pathophysiological effects

Abstract: G-protein-coupled receptors (GPCRs) are recognized as the largest protein receptor superfamily, which are widely distributed in various tissues and organs. In addition, GPCRs are involved in many physiological and pathological longitudinal responses. Studies have indicated that putative receptor protein related to AT1 (APJ receptor) is an orphan GPCRs until its endogenous ligand apelin is found. Recently, Elabela, a new APJ receptor endogenous ligand was also found. Some evidence showed that the APJ receptor i… Show more

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Cited by 30 publications
(17 citation statements)
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References 105 publications
(191 reference statements)
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“…The APJ receptor, first identified in 1993, is a member of the G protein-coupled receptor family closely related to the angiotensin receptor, but it is not coupled by angiotensin II [85,86]. Only in 1998 was an APJ endogenous ligand found: apelin (APLN) [87].…”
Section: Apelin/apj Axis: Biological Rolementioning
confidence: 99%
See 1 more Smart Citation
“…The APJ receptor, first identified in 1993, is a member of the G protein-coupled receptor family closely related to the angiotensin receptor, but it is not coupled by angiotensin II [85,86]. Only in 1998 was an APJ endogenous ligand found: apelin (APLN) [87].…”
Section: Apelin/apj Axis: Biological Rolementioning
confidence: 99%
“…Recent evidence highlights how APLN has many biological functions and above all plays a crucial role in the cardiovascular and metabolic systems [84,86,88].…”
Section: Apelin/apj Axis: Biological Rolementioning
confidence: 99%
“…; Huang et al. ), the podocyte apelinergic system may become a good target for the treatment of DKD.…”
Section: Discussionmentioning
confidence: 99%
“…APJ is a G protein‐coupled receptor consisting of seven transmembrane domains, that shares a 31% identical amino acid sequence with angiotensin AT1 receptor, but does not bind angiotensin II (Ang II) (Huang et al. ). Messenger RNA (mRNA) molecules for preproapelin and APJ are expressed in human tissues such as stomach, brain, heart, kidney, adipose tissue, lung, and in human endothelial cells (Hosoya et al.…”
Section: Introductionmentioning
confidence: 99%
“…APLNR is an orphaned G-protein-coupled receptor (GPCR), which distributed widely throughout the body, including central nervous system, heart, kidney, and other periphery organs [24,25] . According to the reports, APLNR has no other subtypes and has two known ligands: Apelin and Elabela [26] . Previous studies had showed that Apelin had protective effects against oxidative induced injuries.…”
Section: Introductionmentioning
confidence: 99%