Targeting emerging cancer hallmarks by transition metal complexes: Cancer stem cells and tumor microbiome. Part I

Chang, Meng Rui; Русанов, Даниил А.; Arakelyan, Jemma; Alshehri, Mana; Асатурова, А. В.; Kireeva, Galina S.; Babak, Maria V.; Ang, Wee Han

doi:10.1016/j.ccr.2022.214923

Cited by 6 publications

(3 citation statements)

References 365 publications

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“…, polypyridine-based metal complexes, cyclometalated complexes, or triphenylphosphine-based metal complexes) have been developed. 28–32 Among the most promising classes of compounds, cyclometalated Ir( iii ) complexes have received increased attention due to their high physiological stability, biocompatibility, and attractive pharmacokinetic properties. Based on their rich photophysical properties ( i.e.…”

Section: Introductionmentioning

confidence: 99%

“…26,27 Over the last years, various types of mitochondria-targeting therapeutic metal complexes (i.e., polypyridine-based metal complexes, cyclometalated complexes, or triphenylphosphinebased metal complexes) have been developed. [28][29][30][31][32] Among the most promising classes of compounds, cyclometalated Ir(III) complexes have received increased attention due to their high physiological stability, biocompatibility, and attractive pharmacokinetic properties. Based on their rich photophysical properties (i.e., strong luminescence, signicant Stokes shi, high ROS production) that can be ne-tuned through the choice of the ligand environment, cyclometalated Ir(III) complexes are widely studied as photosensitizers for photodynamic therapy (PDT).…”

Section: Introductionmentioning

confidence: 99%

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An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death

Feng,

Tang,

Karges

et al. 2024

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death

Feng,

Tang,

Karges

et al. 2024

Chem. Sci.

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“…Copper-coordination compounds are an attractive class of compounds for the development of novel cancer treatments [2][3][4][5]. Different copper complexes with antitumor activity have been synthesized and characterized, with promising results, even presenting antimetastatic and antiangiogenic activities (in vitro assays) or being cytotoxic to cancer stem cells [3,4,[6][7][8][9][10][11][12][13]. Cu(II) complexes of ligands with no appreciable cytotoxic activity are active, indicating that the metal itself plays a role in antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, DNA Binding and Cytotoxicity of Copper(II) Phenylcarboxylate Complexes

Fernández,

Rocha,

Azam

et al. 2023

Inorganics

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Coordination compounds of copper exhibit cytotoxic activity and are suitable for the search for novel drug candidates for cancer treatment. In this work, we synthesized three copper(II) carboxylate complexes, [Cu2(3-(4-hydroxyphenyl)propanoate)4(H2O)2]·2H2O (C1), [Cu2(phenylpropanoate)4(H2O)2] (C2) and [Cu2(phenylacetate)4] (C3), and characterized them by elemental analysis and spectroscopic methods. Single-crystal X-ray diffraction of C1 showed the dinuclear paddle-wheel arrangement typical of Cu–carboxylate complexes in the crystal structure. In an aqueous solution, the complexes remain as dimeric units, as studied by UV-visible spectroscopy. The lipophilicity (partition coefficient) and the DNA binding (UV visible and viscosity) studies evidence that the complexes bind the DNA with low Kb constants. In vitro cytotoxicity studies on human cancer cell lines of metastatic breast adenocarcinoma (MDA-MB-231, MCF-7), lung epithelial carcinoma (A549) and cisplatin-resistant ovarian carcinoma (A2780cis), as well as a nontumoral lung cell line (MRC-5), indicate that the complexes are cytotoxic in cisplatin-resistant cells.

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Remotely Controllable Supramolecular Nanomedicine for Drug‐Resistant Colorectal Cancer Therapy Caused by Fusobacterium nucleatum

Yan,

Xin,

et al. 2023

Small Methods

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Fusobacterium nucleatum (Fn) existing in the community of colorectal cancer (CRC) promotes CRC progression and causes chemotherapy resistance. Despite great efforts that have been made to overcome Fn‐induced chemotherapy resistance by co‐delivering antibacterial agents and chemotherapeutic drugs, increasing the drug‐loading capacity and enabling controlled release of drugs remain challenging. In this study, a novel supramolecular upconversion nanoparticle (SUNP) is constructed by incorporating a positively charged polymer (PAMAM‐LA‐CD) with Fn inhibition capacity, a negatively charged platinum (IV) oxaliplatin prodrug (OXA–COOH), upconversion nanoparticle (UCNPs) and polyethylene glycol–azobenzene (PEG–Azo) to enhance drug‐loading and enable on‐demand drug release for drug‐resistant CRC treatment. SUNPs exhibit high drug‐loading capacity (30.8%) and good structural stability under normal physiological conditions, while disassembled upon exogenous NIR excitation and endogenous azo reductase in the CRC microenvironment to trigger drug release. In vitro and in vivo studies demonstrate that SUNPs presented good biocompatibility and robust performance to overcome chemoresistance, thereby significantly inhibiting Fn‐infected cancer cell proliferation. This study leverages multiple dynamic chemical designs to integrate both advantages of drug loading and release in a single system, which provides a promising candidate for precision therapy of bacterial‐related drug‐resistant cancers.

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Targeting emerging cancer hallmarks by transition metal complexes: Cancer stem cells and tumor microbiome. Part I

Cited by 6 publications

References 365 publications

An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death

An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death

Synthesis, Characterization, DNA Binding and Cytotoxicity of Copper(II) Phenylcarboxylate Complexes

Remotely Controllable Supramolecular Nanomedicine for Drug‐Resistant Colorectal Cancer Therapy Caused by Fusobacterium nucleatum

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